NorthStar Node of the Clinical Trials Network

临床试验网络的 NorthStar 节点

基本信息

批准号：
10583144
负责人：
GAVIN BART
金额：
$ 650.79万
依托单位：
HENNEPIN HEALTHCARE RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-01 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10583144
关键词：
Address Adoption Algorithms American Artificial Intelligence Big Data Cannabis Cardiovascular Diseases Caring Childhood Chronic Chronic Disease Clinic Clinical Clinical Research Clinical Sciences Clinical Treatment Clinical Trials Network Communities Comparative Effectiveness Research Counseling County Criminal Justice Data Science Development Diagnosis Disease Outcome Dose Drug Kinetics Drug abuse Drug user Electronic Health Record Ensure Federally Qualified Health Center Fellowship Program Guidelines HIV Health Health Personnel Health Services Research Health system Healthcare Helping to End Addiction Long-term Homelessness Housing Human Resources Infrastructure Institutes Institution Integrated Health Care Systems Intervention Iowa Learning Machine Learning Major Depressive Disorder Medical Medicine Mental disorders Mentors Methamphetamine Methamphetamine use disorder Midwestern United States Minnesota Mission Modeling Multi-Institutional Clinical Trial National Institute of Drug Abuse Natural Language Processing Neurosciences North Dakota Opiate Addiction Opioid Outcome Patient Care Patient-Focused Outcomes Patients Persons Pharmaceutical Preparations Policies Population Population Heterogeneity Positioning Attribute Primary Health Care Protocols documentation Psychiatry Public Health Public Health Informatics Randomized Controlled Trials Recovery Research Research Personnel Rural SECTM1 gene Scientist Site Social Work South Dakota Speed Student Health Services Substance Use Disorder Sum Technology Transfer Testing Training Training Programs Translating Translational Research Translations Treatment outcome Underrepresented Minority United States National Institutes of Health Universities Viral hepatitis Wisconsin Workforce Development addiction adolescent health base career clinical practice cognitive training collaborative care community based participatory research community engagement comorbidity evidence base health care delivery health care service utilization illicit drug use implementation science improved innovation machine learning algorithm medical specialties novel therapeutic intervention novel therapeutics opioid misuse personalized medicine pragmatic implementation pragmatic trial precision medicine predictive modeling research and development research data dissemination rural area safety net screening special interest group substance use treatment program university student urban Native American urban area working group

项目摘要

This study is part of the NIH’s Helping to End Addiction Long-term (HEAL) initiative to speed scientific solutions to the national opioid public health crisis. The NIH HEAL Initiative bolsters research across NIH to improve treatment for opioid misuse and addiction. Since joining the NIDA National Drug Abuse Treatment Clinical Trials Network (CTN) in 2015, the NorthStar Node has made significant contributions to the objectives and priorities of the CTN. The NorthStar Node and its investigators have led or co-led five CTN protocols, served as a research site for seven CTN studies, co- chaired the CTN Steering Committee and the Data Science Work Group, served on the Research Development Committee, and contributed to several special interest groups. The NorthStar Node's research portfolio includes traditional randomized controlled trials (CTN-0068), pragmatic comparative effectiveness research (CTN-0098A and CTN-0099), implementation science (CTN-0074, CTN-0098B, and CTN-0099), community-based participatory research (CTN-0096), data science (CTN-0076 and CTN-0087), and health services research (CTN-0070). In this application, the NorthStar Node has seven guiding objectives (POLARIS): 1) generating evidence that informs Policy and clinical guidelines; 2) evaluating models addressing co-Occurring SUD and medical and psychiatric conditions; 3) using principals of a Learning health system to conduct pragmatic trials; 4) using Artificial intelligence and other data sciences approaches to enhance SUD research and care; 5) Reaching understudied populations to ensure SUD research is relevant to diverse populations; 6) using Implementation science to test the integration of evidence-based SUD practices into general medical settings; and 7) testing innovative Strategies for SUD treatment. Potential studies to meet these objectives include 1) a novel therapeutic intervention for methamphetamine use disorder; 2) development of machine learning algorithms in the electronic health record to target substance use screening and enhance substance use disorder diagnoses; 3) precision/personalized medicine studies using population pharmacokinetics to better define and refine medication dosing strategies that improve treatment outcome; and 4) testing collaborative care models to address co-occurring chronic medical illnesses in specialty addiction treatment settings. Our expertise spans multi-site clinical trials, implementation science, community-based participatory research, EHR-based interventions, machine learning and natural language processing, and health services research. In addition to community partners that include urban and rural integrated health systems, federally qualified health centers serving underrepresented minorities, specialty addiction treatment programs, and pediatric and adolescent health clinics, the NorthStar Node brings affiliated research and dissemination networks into the CTN, including CTSA, SIREN, PCORNet, JCOIN, HOPE, the Network Coordinating Office of the Addiction Technology Transfer Centers, a learning health system training program (K12), three NIDA training programs (T32), and fellowship programs in addiction medicine and addiction psychiatry. The NorthStar Node is well situated to address current and emerging SUD issues and advance research in the field in order to improve patient outcome and transform health systems.

这项研究是 NIH 帮助结束成瘾长期 (HEAL) 计划的一部分，该计划旨在加快国家阿片类药物公共卫生危机的科学解决方案，自加入该计划以来，NIH HEAL 计划加强了整个 NIH 的研究，以改善对阿片类药物滥用和成瘾的治疗。 2015 年 NIDA 国家药物滥用治疗临床试验网络 (CTN) 中，NorthStar 节点为 CTN 的目标和优先事项做出了重大贡献 NorthStar 节点及其研究者已领导或共同领导了 5 个项目。 CTN 协议，作为七项 CTN 研究的研究地点，共同担任 CTN 指导委员会和数据科学工作组主席，在研究开发委员会任职，并为多个特殊兴趣小组做出了贡献。 NorthStar Node 的研究组合包括传统随机对照试验 (CTN-0068)、实用比较有效性研究 (CTN-)。 0098A 和 CTN-0099）、实施科学（CTN-0074、CTN-0098B 和 CTN-0099）、基于社区的参与性研究 (CTN-0096)、数据科学（CTN-0076 和 CTN-0087）以及卫生服务研究 (CTN-0070) 在此应用中，北极星节点有七个指导目标 (POLARIS)：1)生成为政策和临床指南提供信息的证据；2) 评估解决同时发生的 SUD 以及医疗和精神疾病的模型；3) 使用学习健康的原则；系统进行务实试验； 4) 使用人工智能和其他数据科学方法来加强 SUD 研究和护理； 5) 覆盖未受研究的人群，以确保 SUD 研究与不同人群相关； 6) 使用实施科学来测试证据的整合将 SUD 实践纳入一般医疗环境；7) 测试 SUD 治疗的创新策略，以实现这些目标，包括 1) 针对甲基苯丙胺使用障碍的新型治疗干预措施；开发电子健康记录中的机器学习算法，以针对药物使用筛查并增强药物使用障碍诊断；3）利用人群进行精准/个性化医学研究；药代动力学，以更好地定义和完善药物剂量策略，以改善治疗结果；4) 测试协作护理模型，以解决专业成瘾治疗环境中同时发生的慢性疾病。参与性研究、基于电子病历的干预措施、机器学习和自然语言处理以及卫生服务研究。此外，社区合作伙伴还包括城乡综合卫生系统、为合格少数群体提供服务的联邦卫生中心、专业成瘾治疗计划以及儿科和青少年。健康诊所，北极星节点带来了附属研究和 CTN 传播网络，包括 CTSA、SIREN、PCORNet、JCOIN、HOPE、成瘾技术转移中心网络协调办公室、学习健康系统培训计划 (K12)、三个 NIDA 培训计划 (T32) 以及北极星节点非常适合解决当前和新出现的 SUD 问题并推进该领域的研究，以改善患者的治疗结果并转变卫生系统。