Oklahoma Center of Medical Imaging for Translational Cancer Research

俄克拉荷马州转化癌症研究医学影像中心

基本信息

批准号：
10573264
负责人：
Javier Antonio Jo
金额：
$ 226.22万
依托单位：
UNIVERSITY OF OKLAHOMA
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-02-15 至 2026-12-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10573264
关键词：
Address Advanced Malignant Neoplasm Advisory Committees American Cancer Society American Indians Area Authorization documentation Biomedical Engineering Cancer Burden Cancer Center Cancer Patient Cancer Research Project Centers of Research Excellence Clinical Clinical Data Clinical Research Collaborations Communities Data Databases Dedications Development Diagnosis Early Diagnosis Economic Burden Education Engineering Ensure Environment Equipment Faculty Fostering Funding Future Goals Health Health Sciences Healthcare Image Imaging Techniques Imaging technology Infrastructure Interdisciplinary Study Investments Joints Lead Leadership Machine Learning Malignant Neoplasms Medical Imaging Medical center Mentors Methods Molecular Morphology National Cancer Institute Oklahoma Physicians Physiology Pilot Projects Play Positioning Attribute Prognosis Public Health Publishing Regulation Research Research Activity Research Infrastructure Research Personnel Research Project Grants Research Support Research Training Resource Sharing Resources Role Scientist Screening for cancer Security Services Societies Software Tools Statistical Data Interpretation Strategic Planning Translational Research Tribes Universities Vertebrates Water authority biomedical imaging cancer imaging cancer risk cancer therapy career clinical imaging clinically relevant cohort college data resource experience human subject image processing imaging biomarker imaging facilities imaging informatics improved in vivo individual patient innovation mortality multidisciplinary novel overtreatment personalized medicine precision medicine predictive marker programs quantitative imaging research study risk prediction screening social success synergism technology development tool translational cancer research tumor diagnosis

项目摘要

Oklahoma Center of Medical Imaging for Translational Cancer Research Abstract – Overall Component In order to highly align with the Strategic Plan of the University of Oklahoma (OU) to create the multidisciplinary Research Centers of Excellent in one of the primary research themes namely, the future of health, the overarching objective of this COBRE application is to establish a new medical imaging center for conducting the translational cancer research by leveraging the established research supporting resource and collaboration network between the biomedical engineering and clinical research in OU. This COBRE will provide research infrastructure along with the multidisciplinary leadership and mentoring teams to support the promising research project leaders (RPLs) of the junior investigators as they establish independent research careers. An essential component will be providing support for innovative research projects that develop and apply novel medical imaging technology and quantitative imaging predictive markers to translational cancer research. The success of these research projects will make impact and contribution to the future of health including the advance of the precision medicine to significantly improve efficacy of the personalized cancer risk prediction, screening, diagnosis and treatment. Since 2012, OU has developed and established a collaborative network and diverse portfolio of research projects that bridge the biomedical imaging engineering faculty in the Gallogly College of Engineering (GCoE) with the physician scientists or clinical researchers in the Stephenson Cancer Center (SCC). Building on our experience in conducting joint translational cancer research using medical imaging technology, this COBRE aims to support and further develop this collaborative research infrastructure between the GCoE and SCC to enhance the research capability and progress of the RPLs as they further develop the team-based and translational research projects. In order to promote the translational research projects with potentially high clinical impact and significance, this COBRE will include the RPLs with both biomedical imaging engineering and clinical research training backgrounds. Each RPL will also have two senior mentors with expertise in biomedical engineering and clinical research, respectively, to further enhance the collaborative research approach. In summary, in order to enhance the medical imaging related translational cancer research capacity in OU and ensure RPLs to establish independent research careers, we propose the following three Specific Aims in this COBRE: (1) to implement a dedicated program for mentoring RPLs in their proposed research projects and enabling them to become independent researchers with non-IDeA external research support; (2) to strengthen and develop new research infrastructure and shared resources to support current and future medical imaging related translational cancer research projects; and (3) to foster and enhance the multidisciplinary collaborative research activities between the biomedical engineering faculty and physician scientists or clinical researchers to facilitate the outstanding translational medical imaging related cancer research projects.

俄克拉荷马州转化癌症研究医学影像中心摘要——总体组成部分为了与俄克拉荷马大学（OU）的战略计划高度一致，创建卓越的多学科研究中心的主要研究主题之一，即未来健康，该 COBRE 应用程序的首要目标是为以下人群建立一个新的医学成像中心：利用现有的研究支持资源进行转化癌症研究该 COBRE 将提供 OU 生物医学工程和临床研究之间的合作网络。研究基础设施以及多学科领导和指导团队，以支持有前途的初级研究人员建立独立研究生涯时的研究项目负责人（RPL）。重要组成部分将是为开发和应用新颖的创新研究项目提供支持医学成像技术和定量成像预测标记在转化癌症研究中的应用。这些研究项目的成功将对健康的未来产生影响和贡献，包括推进精准医疗显着提高个性化癌症风险预测、筛查、自 2012 年以来，OU 开发并建立了多元化的协作网络。连接加洛格利学院生物医学成像工程系的研究项目组合与斯蒂芬森癌症中心 (SCC) 的医师科学家或临床研究人员一起进行工程 (GCoE)。基于我们利用医学成像技术进行联合转化癌症研究的经验，该 COBRE 旨在支持和进一步发展 GCoE 之间的合作研究基础设施和SCC在进一步开发基于团队的过程中提高RPL的研究能力和进度和转化研究项目，以促进具有高潜力的转化研究项目。临床影响和意义，该 COBRE 将包括具有生物医学成像工程和每个RPL还将拥有两名具有生物医学专业知识的高级导师。工程和临床研究分别进一步加强协作研究方式。总结，为了增强OU和OU的医学影像相关转化癌症研究能力确保RPL建立独立的研究生涯，我们在此提出以下三个具体目标 COBRE：(1) 实施专门计划，指导 RPL 拟议的研究项目和（二）强化开发新的研究基础设施和共享资源以支持当前和未来的医学成像相关转化癌症研究项目；(3) 促进和加强多学科合作生物医学工程学院和医师科学家或临床研究人员之间的研究活动促进杰出的转化医学成像相关癌症研究项目。