The UNC Chapel Hill Superfund Research Program (UNC-SRP)

北卡罗来纳大学教堂山超级基金研究计划 (UNC-SRP)

基本信息

批准号：
10570837
负责人：
Rebecca Fry
金额：
$ 246.18万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-02-20 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10570837
关键词：
Address Amendment Arsenic Authorization documentation Biological Businesses Chemicals Chemistry Collaborations Communication Communities Data Analyses Development Diabetes Mellitus Disease Ensure Environmental Science Excision Exposure to Foundations Future Genotype Human In Vitro Individual Industrialization Industry Institution Intervention Knowledge Link Metabolic Diseases Metabolic dysfunction Methods Methyltransferase MicroRNAs Mission North Carolina Pollution Population Predisposition Prevalence Prevention Privatization Public Health Regulation Research Research Personnel Research Project Grants Research Technics Risk Rivers Sampling Science Scientist Signal Recognition Particle Site Soil Source Southeastern United States Superfund Techniques Technology Training Translating Translational Research United States Universities Vision Water Wood material Work authority coal ash community engagement data integration data management diabetes risk disorder prevention disorder risk drinking environmental justice experience gut microbiome in vivo Model innovation interdisciplinary approach next generation novel novel strategies prevent programs rural area superfund site transcription factor vulnerable community

项目摘要

ABSTRACT: THE UNC-CHAPEL HILL SUPERFUND RESEARCH PROGRAM The interdisciplinary Superfund Research Program at the University of North Carolina at Chapel Hill (UNC-SRP) will address serious public health challenges faced by communities in North Carolina (NC) and across the nation related to inorganic arsenic (iAs). The UNC-SRP prioritizes iAs as the focus contaminant as it is highly relevant to millions in NC and the US exposed to unsafe levels. In NC, contamination is derived from both geogenic sources and industrial activities (e.g. superfund sites and coal ash contamination) polluting thousands of private wells. An estimated ~3 million individuals in NC, representing one third of the state’s population, drink water from private wells, with iAs ranging up to 800 ppb. These populations are largely located in the rural areas of NC with established environmental justice conditions. Moreover, iAs contamination reverberates across the state and is locally and nationally-relevant. Related to public health risk, exposure to iAs has been established to be associated with metabolic dysfunction/diabetes. There is a significant gap in the knowledge of factors that drive iAs-induced diabetes risk. The identification of these factors would facilitate development of novel solutions/interventions to reduce the prevalence of iAs-associated diabetes, as well as other diseases associated with iAs exposure. Our unique scientific theme is “Identifying novel methods to reduce iAs exposure and elucidating mechanisms underlying iAs-induced metabolic dysfunction with a vision for disease prevention.” We address this with three aims: (1) Discover biological mechanisms and susceptibility factors underlying iAs-associated metabolic dysfunction/diabetes; (2) Develop novel methods and technologies to predict iAs contamination and reduce iAs exposure; (3) Translate the science of the UNC-SRP to key stakeholders in NC and the larger SRP program, and engage vulnerable communities. The UNC-SRP comprises five research projects. Projects 1-3 use highly translational techniques spanning in vitro and in vivo models, and human populations to understand mechanisms of iA-induced diabetes. Projects 4-5 advance the ability to predict iAs contamination in private drinking wells and innovative methods for enhanced removal of iAs. With relevance to the national SRP program, we will work with site managers at the Fairfax St. Wood Treaters Superfund site. Five Cores include the Administrative Core, the Community Engagement Core, Data management and Analysis Core (DMAC), Research Experience and Training Coordination Core (RETCC), and Chemistry and Analysis Core (CAC). These Cores facilitate administration, community engagement with our partners Clean Water for NC and the Winyah Rivers Foundation, data management and analysis, training, and chemical analyses. In sum, the UNC-SRP mission is to develop new solutions for iAs reduction and disease prevention through mechanistic and translational research to ultimately inform regulation and Superfund site cleanup efforts.

摘要：北卡罗来纳大学教堂山超级基金研究计划北卡罗来纳大学教堂山分校跨学科超级基金研究计划 (UNC-SRP) 将解决北卡罗来纳州 (NC) 和全国各地社区面临的严重公共卫生挑战 UNC-SRP 将 iAs 列为重点污染物，因为它具有高度相关性。北卡罗来纳州和美国的数百万人面临不安全水平的污染。在北卡罗来纳州，污染来自于地理因素。污染源和工业活动（例如超级基金场地和煤灰污染）污染了数以千计的私人北卡罗来纳州约有 300 万人（占该州人口的三分之一）饮用井水。私人水井的 IAs 高达 800 ppb 这些人口主要位于北卡罗来纳州的农村地区。此外，砷污染在全州范围内产生了影响，并且正在发生。与当地和国家相关的公共健康风险，暴露于 iAs 已被确定为与代谢功能障碍/糖尿病相关的驱动因素的知识存在显着差距。 iAs 诱发的糖尿病风险的识别将有助于新型药物的开发。降低 iAs 相关糖尿病以及其他相关疾病患病率的解决方案/干预措施我们独特的科学主题是“确定减少 iAs 暴露和的新方法”。阐明 iAs 诱导的代谢功能障碍的机制，并展望疾病我们通过三个目标来解决这个问题：（1）发现生物学机制和易感因素。潜在的 iAs 相关代谢功能障碍/糖尿病；(2) 开发新方法和技术预测 iAs 污染并减少 iAs 暴露；(3) 将 UNC-SRP 的科学转化为关键 NC 和更大的 SRP 计划的利益相关者以及弱势群体参与社区 UNC-SRP 包括。五个研究项目 1-3 使用跨越体外和体内模型的高度转化技术，以及项目 4-5 旨在帮助人们了解 iA 诱发糖尿病的机制，从而提高预测能力。私人饮井中的 iAs 污染和增强去除 iAs 的创新方法。根据国家 SRP 计划，我们将与 Fairfax St. Wood Treaters Superfund 工厂的现场经理合作。五个核心包括行政核心、社区参与核心、数据管理和分析核心 (DMAC)、研究经验和培训协调核心 (RETCC) 以及化学和分析核心 (CAC)。这些核心促进管理以及与我们的合作伙伴清洁水的社区参与。 NC 和 Winyah Rivers 基金会，数据管理和分析、培训以及化学分析。 UNC-SRP 的使命是通过以下方式开发减少 IAs 和疾病预防的新解决方案：机制和转化研究，最终为监管和超级基金现场清理工作提供信息。