Core A: Administrative Core

核心A：行政核心

• 批准号: 10570838
• 负责人: Rebecca Fry
• 金额: $ 21.74万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-20 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10570838
• 关键词: Advisory Committees; Area; Biological; Biomedical Research; Budgets; Businesses; Cell Culture Techniques; Chemistry; Communication; Communities; Data; Data Analyses; Diabetes Mellitus; Diabetes prevention; Ensure; Environment; Environmental Engineering technology; Environmental Health; Environmental Science; Excision; Feedback; Fostering; Foundations; Goals; Health; Health Professional; Human; Human Resources; In Vitro; Institution; Interdisciplinary Study; Leadership; Mentors; Metabolic Diseases; Metabolic dysfunction; Methods; Mission; Monitor; National Institute of Environmental Health Sciences; North Carolina; Performance; Population; Postdoctoral Fellow; Predisposition; Privatization; Program Research Project Grants; Progress Reports; Public Health; Recording of previous events; Research; Research Activity; Research Personnel; Research Project Grants; Research Support; Rivers; Role; Sampling; Science; Signal Recognition Particle; Strategic Planning; Superfund; Techniques; Technology; Training; Translating; Translational Research; Universities; Vision; Vulnerable Populations; Water; Wood material; Work; career development; community engagement; data management; disorder prevention; drinking; experience; graduate student; in vitro Model; in vivo Model; innovation; meetings; mouse model; novel; programs; success; superfund site; training opportunity; translational approach; translational engagement; vulnerable community

ABSTRACT: ADMINISTRATIVE CORE The Administrative Core is the driver for the planning and coordination of all activities within the University of North Carolina Superfund Research Program (UNC-SRP). It ensures that the research aligns with our overarching mission-to develop new solutions for iAs reduction and disease prevention through mechanistic and translational research. The role of the Administrative Core is to oversee and facilitate the conduct of work within the UNC-SRP to ensure responsiveness to the SRP mandates. In addition to fulfilling mandates of the SRP program, we implement research that is in line with the 2018-2023 NIEHS Strategic Plan. This Core oversees the nine other components of the UNC-SRP. Projects 1-3 use highly translational techniques spanning in vitro and in vivo models, and human populations to understand mechanisms of iA-induced metabolic dysfunction/diabetes. Projects 4-5 advance the ability to predict iAs contamination in private drinking wells and innovative methods for enhanced removal to reduce iAs. Across Projects, we use a translational approach that spans in vitro models and cell culture, mouse models, and human samples. Four Cores include the Community Engagement Core, Data management and Analysis Core (DMAC), Research Experience and Training Coordination Core (RETCC), and Chemistry and Analytical Core (CAC). The UNC-SRP Director is Dr. Rebecca Fry, a Biomedical Researcher, who is supported in this role by Deputy Director Dr. Fernando Pardo-Manuel de Villena (Biomedical Researcher) and Assistant Director, Dr. Michael Aitken (Environmental Engineer). Drs. Fry, Pardo-Manuel de Villana and Aitken have extensive experience with administration and oversight of large research efforts, established leadership in successful mentoring, and complementary scientific expertise relevant to the proposal. Their interdisciplinary expertise and experience contributes significantly to the goal of the Administrative Core is to foster an environment that stimulates innovative science and ensures that all UNC- SRP Projects and Cores work toward the overarching theme, “Identifying novel methods to reduce iAs exposure and elucidating mechanisms underlying iAs-induced metabolic dysfunction with a vision for disease prevention.” The goal of the Core is achieved through four aims. First, we integrate, coordinate, and monitor UNC-SRP interdisciplinary research activities focused on iAs reduction and metabolic disease/diabetes prevention. Second, we convene advisory groups to provide critical guidance on UNC-SRP activities. Third, we develop effective research translation and communication strategies for UNC-SRP stakeholders related to iAs reduction and disease prevention. Finally, we provide training and career development opportunities for graduate students and post-doctoral fellows that foster integration across the Biomedical and Environmental Science research areas. Combined, these aims ensure a thriving research program bolstered by substantive interaction with translation and community engagement partners, collectively focusing the UNC-SRP to achieve our mission. !

摘要：管理核心 行政核心是计划和协调大学内所有活动的驱动力 北卡罗来纳州超级基金研究计划（UNC-SRP）。它确保研究与我们的 通过 机械和翻译研究。行政核心的作用是海外和促进 在UNC-SRP内进行工作以确保对SRP授权的响应能力。除了实现 SRP计划的任务，我们实施了与2018 - 2023 NIEHS战略计划一致的研究。 该核心监督UNC-SRP的其他九个组件。项目1-3使用高度翻译的技术 跨越体内和体内模型，以及人类种群，以了解IA诱导的代谢机制 功能障碍/糖尿病。项目4-5提高了预测私人饮酒井中IAS污染的能力， 创新方法以增强去除以减少IAS。在整个项目中，我们使用一种翻译方法 跨越体外模型和细胞培养，小鼠模型和人类样品。四个核心包括社区 参与核心，数据管理和分析核心（DMAC），研究经验和培训 协调核心（RETCC）以及化学和分析核心（CAC）。 UNC-SRP主任是Rebecca博士 生物医学研究人员Fry，由副主任Fernando Pardo-Manuel de支持此职位 Villena（生物医学研究人员）和助理主任Michael Aitken博士（环境工程师）。弗莱博士， Pardo-Manuel de Villana和Aitken在管理和监督方面有丰富的经验 研究工作，在成功的心理方面建立领导才能以及完整的科学专业知识相关 提出建议。他们的跨学科专业知识和经验对目标的目标做出了重大贡献 行政核心是促进一个刺激创新科学的环境，并确保所有unc- SRP项目和核心致力于总体主题：“确定减少IAS暴露的新方法 并阐明IAS诱导的代谢功能障碍的基础机制，并具有预防疾病的愿景。” 核心的目标是通过四个目标实现的。首先，我们集成，协调和监视UNC-SRP 跨学科研究活动的重点是减少IAS和代谢疾病/糖尿病。 其次，我们便利的咨询小组为UNC-SRP活动提供关键指导。第三，我们发展 与IAS减少有关的UNC-SRP利益相关者的有效研究翻译和沟通策略 和疾病预防。最后，我们为研究生提供培训和职业发展机会 以及促进生物医学和环境科学研究促进融合的博斯特研究员 区域。这些目标结合在一起，确保了通过与 翻译和社区参与合作伙伴，集体集中于UNC-SRP以实现我们的使命。 呢