Bioinspired Green Glycolipids as Fugitive Dust Mitigation Agents

仿生绿色糖脂作为扬尘减排剂

• 批准号: 10484307
• 负责人: Chett J Boxley
• 金额: $ 17.31万
• 依托单位: GLYCOSURF, INC.
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-24 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10484307
• 关键词: Address; Affect; Agriculture; Air; Amendment; Area; Arizona; Arsenic; Caliber; Cellulose; Cessation of life; Chemicals; Climate; Coal; Corrosives; Data; Development; Disadvantaged; Dust; Effectiveness; Environmental Health; Environmental Risk Factor; Environmental Wind; Equipment; Film; Formulation; Glycolipids; Goals; Hardness; Health; Health Hazards; High temperature of physical object; Human; Hydrophobicity; Industry; Infrastructure; Inhalation; Laboratories; Lead; Lung; Mechanics; Minerals; Mining; Modernization; Morbidity - disease rate; Outcome; Particulate Matter; Performance; Phase; Polymers; Precipitation; Process; Public Health; Research; Resistance; Risk; Sales; Sampling; Site; Small Business Innovation Research Grant; Soil; Solubility; Surface; System; Tail; Technology; Testing; Thick; Thinness; Toxic effect; Transportation; Ultraviolet Rays; United States Environmental Protection Agency; Universities; Viscosity; Water; Work; ambient air pollution; base; burden of illness; candidate identification; cardiovascular health; coarse particles; commercialization; economic evaluation; efficacy testing; exposure route; extreme temperature; field study; fine particles; indexing; industry partner; innovation; mineral dust; mortality; new technology; next generation; operation; particle; respiratory health; success; surfactant; virtual; wasting

Project Summary Ambient air pollution is a leading contributor to global disease burden that increases morbidity and mortality, and it accounted for 4.2 million deaths in 2015. Mineral dusts are a constituent of total atmospheric particulate matter that affect global biogeochemical cycles, pollute water bodies and air masses, and impact global climate. Dust presents physical (i.e., reduced visibility and explosive mixtures) and health hazards, particularly affecting cardiovascular and respiratory health. Mining generates dust in virtually every step of the mining process: excavating, blasting, stockpiling, crushing, grinding, and transport. Dust generated from both modern and legacy mining operations is known to be an exposure route for other contaminants (e.g. arsenic and lead). To protect human and environmental health from mining related dusts, it is important to develop innovative, environmentally-compatible technologies capable of mitigating dust emissions. Preliminary data has demonstrated glycolipid surfactants are effective dust suppressants with efficacy equal to or better than currently available products. Though a variety of dust suppression products are commercially available, disadvantages provide market opportunities that new technologies can address: (i) they are often corrosive to machinery, (ii) they can cause potential risks to human health due to hazardous components, and (iii) they have short-term effectiveness due to the fragility of the protection layer that can be easily disrupted by environmental factors, such as strong wind. The overall goal of this Phase I SBIR is to demonstrate the commercial potential for a next generation green dust suppression technology that combines GlycoSurf’s proprietary glycolipid surfactants with cellulose polymers to develop marketable dust suppression formulations for two applications: mine tailings that are not subject to mechanical disturbance and unpaved haul roads that undergo substantial mechanical disturbance. The Phase 1 Aims are two-fold. In Aim 1, unique formulations of glycolipids, alone and in combination with cellulose polymers, will be generated with target performance parameters suitable for tailings and unpaved road applications. In Aim 2, these formulations will be tested for dust suppression efficacy and resistance to environmental factors such as UV radiation, precipitation, and high temperature. The stability of glycolipid treatments will also be assessed against mechanical disruption via compression testing. A step-wise testing process will be used to develop formulations that achieve a Good Air Quality Index as defined by the U.S. Environmental Protection Agency. Successful completion of this project will result in the identification of candidate formulations with potential for marketability. These candidate products will subsequently undergo field testing during Phase II research to demonstrate their efficacy protecting environmental and human health under real-world conditions.

项目摘要 环境空气污染是导致全球疾病燃烧的主要因素，从而增加了发病率和死亡率，并且 它在2015年占420万人的死亡。 这会影响全球生物地球化学周期，污染水体和空气质量，并影响全球气候。灰尘 呈现身体（即降低的可见性和爆炸性混合物）和健康危害，尤其影响 心血管和呼吸健康。采矿几乎在采矿过程的每个步骤中产生灰尘： 挖掘，爆炸，储存，压碎，打磨和运输。现代和遗产产生的灰尘 采矿作业已知是其他污染物（例如砷和铅）的暴露途径。保护 与采矿相关的尘埃的人类和环境健康，发展创新，很重要， 能够减轻灰尘排放的环境兼容技术。初步数据具有 证明的糖脂生存者是有效抑制粉尘的有效性，其有效性等于或优于当前 可用产品。尽管各种粉尘抑制产品可商购，但缺点 提供新技术可以解决的市场机会：（i）它们通常对机械具有腐蚀性，（ii） 由于危险组件，它们可能对人类健康造成潜在的风险，并且（iii）它们有短期 由于保护层的脆弱性而引起的有效性，该保护层很容易被环境因素破坏， 例如强风。 I阶段I SBIR的总体目标是展示下一个的商业潜力 将绿色尘埃抑制技术结合在一起，将聚糖的专有糖脂表面活性剂与 纤维素聚合物为两种应用开发可销售的粉尘抑制配方：矿山尾矿 不受机械灾难和未铺设的拖拉道路的约束 干扰。第1阶段的目标是两个倍。在AIM 1中，单独和 将与适合尾矿的目标性能参数一起生成纤维素聚合物 和未铺设的道路申请。在AIM 2中，这些公式将进行测试以抑制粉尘效率和 对环境因素的抗性，例如紫外线辐射，降水和高温。稳定性 还将通过压缩测试来评估糖脂处理。逐步 测试过程将用于开发达到美国定义的良好空气质量指数的公式 环境保护局。成功完成该项目将导致确定 候选公式，具有可销售性的潜力。这些候选产品随后将进行现场 第二阶段研究期间的测试以证明其有效性保护环境和人类健康 现实世界中的条件。