Research Core

研究核心

• 批准号: 10090711
• 负责人: TRUDY F. MACKAY
• 金额: $ 41.64万
• 依托单位: CLEMSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-10 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10090711
• 关键词: Adoption; Animal Model; Award; Bioinformatics; Biology; Centers of Research Excellence; Chromium; Computer software; Core Facility; Custom; DNA Resequencing; Data; Development; Doctor of Philosophy; Educational workshop; Epigenetic Process; Experimental Designs; Faculty; Fee-for-Service Plans; Generations; Genetic; Genome; Genomics; High Performance Computing; Human; Human Genetics; Human Resources; Infrastructure; Institution; Laboratories; Memory; Methods; Modernization; Molecular Biology; Nucleotides; Performance; Pilot Projects; Population; Postdoctoral Fellow; Program Research Project Grants; RNA analysis; Research; Research Personnel; Research Project Grants; Resources; Running; Scientist; Services; Sister; South Carolina; Statistical Data Interpretation; Supervision; Technology; Tissue-Specific Gene Expression; Training; Universities; Variant; Workload; bioinformatics infrastructure; bioinformatics resource; cluster computing; computer infrastructure; computing resources; genome analysis; genome sciences; genome-wide; genomic data; graduate student; high throughput analysis; innovation; instrumentation; nanopore; next generation sequencing; pathogen; programs; sequencing platform; single cell analysis; single molecule; statistics; student training; success; transcriptome sequencing

SUMMARY The ability to generate, store and analyze high throughput genomic data is critical for many aspects of modern biology, and especially for human genetics. The Clemson University Genomics and Bioinformatics Facility (CUGBF) provides small to moderate scale genome analysis and customized bioinformatics services. The Clemson University Center for Human Genetics Genome Sciences Laboratories (CUCHG-GSL) supports in- house high throughput, large scale genome analysis, including third generation single molecule long-read sequencing and single cell analyses, as well as custom bioinformatic and statistical analyses of genomic data. The COBRE in Human Genetics will expand the scope of genomics and bioinformatics at Clemson University and the State of South Carolina by combining and expanding the genomics, bioinformatics and computational infrastructure and personnel of the CUGBF and the CUCHG-GSL under the single umbrella of an enhanced CUGBF. The expanded CUGBF will span the spectrum of next generation sequencing platforms, provide custom bioinformatics and statistical analyses and advice on experimental design, and genomics and bioinformatics seminars and workshops. The enhanced CUGBF will thus provide the infrastructure, project guidance and supervision, and training to empower COBRE in Human Genetics Research and Pilot Project Leaders and their laboratory groups to fully deploy extant and emerging genomic and computational technologies in their research programs. These services will also be available for all Clemson University faculty and their research groups as well as faculty in sister institutions in South Carolina. In addition, the enhanced CUGBF will host monthly genomics and bioinformatics seminars and hands-on workshops to train students, postdoctoral fellows and faculty to become self-sufficient in obtaining and analyzing genomics data. The enhanced CUGBF thus fills three critical needs for the wide scale adoption of modern genomics and bioinformatics research in an Institutional Development Award state: (1) local availability of genomics and computational infrastructure; (2) provision of molecular biology and bioinformatics services to investigators new to such large scale analyses; and (3) training researchers to become self-sufficient in obtaining and analyzing genomics data.

概括 生成、存储和分析高通量基因组数据的能力对于现代医学的许多方面至关重要。 生物学，特别是人类遗传学。克莱姆森大学基因组学和生物信息学设施 (CUGBF) 提供中小型基因组分析和定制生物信息学服务。这 克莱姆森大学人类遗传学中心基因组科学实验室 (CUCHG-GSL) 支持- 进行高通量、大规模基因组分析，包括第三代单分子长读长 测序和单细胞分析，以及基因组数据的定制生物信息学和统计分析。 人类遗传学 COBRE 将扩大克莱姆森大学基因组学和生物信息学的范围 和南卡罗来纳州通过结合和扩展基因组学、生物信息学和计算 CUGBF 和 CUCHG-GSL 的基础设施和人员在增强的单一保护伞下 CUGBF。扩展后的 CGBF 将跨越下一代测序平台的范围，提供 定制生物信息学和统计分析以及实验设计、基因组学和 生物信息学研讨会和讲习班。因此，增强后的 CGBF 将提供基础设施、项目 指导、监督和培训，以增强 COBRE 人类遗传学研究和试点项目的能力 领导者及其实验室小组充分部署现有和新兴的基因组和计算 他们的研究计划中的技术。这些服务也将向克莱姆森大学的所有教师提供 及其研究小组以及南卡罗来纳州姐妹机构的教师。此外，增强的 CGBF 将每月举办基因组学和生物信息学研讨会和实践研讨会，以培训学生、 博士后研究员和教师在获取和分析基因组学数据方面变得自给自足。这 因此，增强的 CGBF 满足了广泛采用现代基因组学的三个关键需求 机构发展奖中的生物信息学研究指出：（1）基因组学的本地可用性和 计算基础设施； (2) 为研究者提供分子生物学和生物信息学服务 new 如此大规模的分析； (3) 培训研究人员能够自给自足地获取和分析 基因组学数据。