Dr. William Coleman Award

威廉·科尔曼博士奖

• 批准号: 10265235
• 负责人: Anna Maria Napoles
• 金额: $ 10.62万
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10265235
• 关键词: Affect; African American; Age; Algorithms; American; Animal Feed; Animals; Antibodies; Area; Award; Bacteria; Biological Markers; Birth; Blood; Blood Cells; Breast Cancer Risk Factor; Campylobacter; Campylobacter jejuni; Cardiovascular Diseases; Cell Line; Cell physiology; Cells; Cessation of life; Cholesterol; Cigar; Cigar Smoking; Code; Communities; DNA Methylation; Data; Data Set; Diagnosis; Diet; Doctor of Medicine; Doctor of Philosophy; Domestic Fowls; Drug Targeting; Dyslipidemias; Education; Electronic Health Record; Endothelial Cells; Environmental Pollution; Environmental Risk Factor; Ethnic Origin; European; Food; Funding; Future; Gastritis; Gender Identity; Genes; Genetic; Genomics; Gold; Health Resources; Helicobacter Infections; Helicobacter pylori; High Density Lipoprotein Cholesterol; Home environment; Human; Human Milk; Immune; Immunoglobulin G; Individual; Infection; Intramural Research Program; Islets of Langerhans; LDL Cholesterol Lipoproteins; Link; Lipopolysaccharide Biosynthesis Pathway; Livestock; Low Birth Weight Infant; Malignant neoplasm of lung; Mammary Neoplasms; Manure; Master of Public Health; Measures; Medical Records; Mentors; Mexican Americans; Modeling; Molecular; National Cancer Institute; National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; Non-Insulin-Dependent Diabetes Mellitus; Normal tissue morphology; Obesity; Pancreas; Participant; Performance; Pharmaceutical Preparations; Phenotype; Pilot Projects; Pima Indian; Population; Population Assessment of Tobacco and Health; Postdoctoral Fellow; Pregnant Women; Prevention; Procedures; Production; Race; Recording of previous events; Research; Research Project Grants; Review Committee; Risk Factors; Role; Rural; Scientist; Signal Transduction; Single Nucleotide Polymorphism; Source; Stomach; Stress; Surveys; Testing; Training; Tumor Subtype; Tumor Tissue; Tumor-infiltrating immune cells; Ulcer; United States National Institutes of Health; Washington; Woman; Work; adaptive immune response; agricultural community; breast milk microbiome; cardiovascular disorder risk; cardiovascular risk factor; cisgender; clinical center; cohort; cytokine; density; design; drug discovery; early pregnancy; ethnic diversity; ethnic minority population; farmer; genetic variant; genome wide association study; genomic locus; health disparity; high risk; induced pluripotent stem cell; innovation; lipoprotein triglyceride; male; malignant stomach neoplasm; man; member; men; microbiome; minority health; neoantigens; offspring; operation; perceived stress; premature; rural dwellers; sex; social culture; sociodemographics; transgender; trimethyloxamine; tumor; young adult

A Coleman award application review committee selected 8 applicants for FY20 funding, described next. These studies demonstrate NIMHD DIR's ability to leverage NIH resources for health disparities research. Julia Chen-Sankey, PhD, MPP, Postdoctoral Fellow, NIHMD. Title: Built and socio-cultural environmental risk factors for cigar smoking among African American Young Adults. Dr. Chen-Sankey's prior work using the Population Assessment of Tobacco and Health Study survey showed that between 20152016, cigar smoking among African American young adults (AAYDs)(ages 18-24) was almost double that of white young adults. This formative research with 40 AAYDs will inform cigar prevention and reduction efforts among AAYDs by gaining an in-depth understanding of (1) built and socio-cultural environmental risk factors for cigar smoking among AAYDs, and(2)how those environmental risk factors influence cigar smoking differently between AAYDs from low and high education backgrounds. Brittny C. Davis Lynn, PhD, MPH, Research Fellow/NCI. Project Title: The breast milk microbiome and its relationship with breast cancer risk factors among black and white women. Molecular breast tumor subtype is known to vary by age, race and ethnicity, the reasons for which are not well understood. Dr. Davis Lynns previous work identified differences in breast milk DNA methylation and breast milk cytokine levels by race among black and white women. Using NCIs Center for Genomic Research, the proposed study will evaluate associations between breast cancer risk factors and the breast milk microbiome (N=400), integrating risk factor and breast milk microbiome data with other breast milk biomarkers (e.g. DNA methylation and cytokine levels), and whether these differ between black and white women. Nicole M. Farmer, M.D. Postdoctoral Fellow National Institutes of Health, Clinical Center. Project Title: Exploring the role of microbiome-related dietary metabolites in cardiovascular disease health disparities. The African American (AA) population is at increased risk of cardiovascular disease (CVD) and diet has a known causal relationship with CVD, however, the exact cellular mechanisms for diet-related CVD remain relatively unknown. This study will: 1) examine TMAO levels and their possible correlation with obesity, CVD risk, or measures of stress within a cohort of AA men and women living in Washington, D.C.; and 2) conduct dietary phenotyping of food sources with TMAO to examine its role in determining CVD risk; and examine the association of TMAO on human aortic endothelial cells (HAoEC) function. Sarah S. Jackson, Ph.D., M.P.H., Postdoctoral Fellow, National Cancer Institute. Project Title: Pilot study to identify transgender individuals within electronic health records. Transgender refers to individuals whose gender identity is different from their assigned sex at birth (e.g., assigned male at birth and identifies as a woman), whereas cisgender is a term for those whose gender identity is aligned with their sex assigned at birth (e.g., assigned male at birth and identifies as a man). The aim of this study is to build and test the preliminary validity of an algorithm using socio-demographics, diagnosis, procedure, and medication codes from electronic health records that can identify transgender identity in large medical records datasets. The validity of the algorithm will compare the performance of the algorithm versus self-identified gender identity as the gold standard for identifying transgender status. This study leverages data from 116,460 participants in the NIH All of Us study. Anup Kumar Nair, Ph.D., Staff Scientist, National Institute of Diabetes and Digestive and Kidney Diseases. Project Title: Modelling the function of type 2 diabetes loci in Pima Indians using iPSCs-derived pancreatic-islet like cells. More recently we have been obtaining induced pluripotent stem cells (iPSC) derived from Pima Indian blood cells of for studying the functional effects of the T2D-associated genes as potential targets for drug discovery. The proposed study will: 1) Identify the effector gene at the KCNQ1 locus which gives rise to the GWAS signal; and 2) determine the efficiency of each isogenic iPSC lines to generate pancreatic beta-like cells. Marion Ouidir, Ph.D., Postdoctoral Fellow, National Institute of Child Health and Human Development. Project Title: Genetic and environmental determinants of early pregnancy maternal dyslipidemia in an ethnic diverse cohort. Abnormal levels of total cholesterol, low-density lipoprotein cholesterol (LDLc), high-density lipoprotein cholesterol (HDLc) and triglycerides in blood is defined as dyslipidemia, and they are risk factors for cardiovascular disease and premature death. Because single nucleotide polymorphisms (SNPs) associated with dyslipidemia were discovered by GWAS predominantly involving male European ancestry populations, information is lacking on pregnant women, where dyslipidemia has been linked with higher or lower birth weight offspring, and on ethnic minorities in the U.S. Thus, the aims of this study are to: 1) identify ancestry-specific and -shared genetic loci for dyslipidemia in early pregnancy; and 2) identify environmental modifiers (such as nativity, perceived stress and obesity status) of the genetic variants that predispose women to dyslipidemia. Emily L. Rossi, Ph.D., M.P.H., Rony Arauz Melendez, Ph.D., M.P.H., and Sheryse Taylor, Ph.D., Postdoctoral Fellows, National Cancer Institute. Project Title: Contribution of genetic ancestry to differences in the immune landscape of lung cancer in European Americans and African Americans. This study will compare African American and European American non-involved adjacent (normal) tissue and tumor tissue to identify: 1) Immune cell subsets enriched in the tumor; 2) differences in tumor immune cell enrichment and tumor-infiltrating immune cell composition by genetic ancestry; and 3) tumor-associated neoantigens and their relationsthe study will compare African American and European American non-involved adjacent (normal) tissue and tumor tissue to identify: 1) Immune cell subsets enriched in the tumor; 2) differences in tumor immune cell enrichment and tumor-infiltrating immune cell composition by genetic ancestry; and 3) tumor-associated neoantigens and their relationship with specific tumor-infiltrating immune cell subsets and genetic ancestry. Joe Shearer, PhD, MPH, Postdoctoral Fellow, NCI. Project Title: Evaluating the impact of concentrated animal feeding operations on Campylobacter jejuni infections in rural agricultural communities. Concentrated animal feeding operations (CAFOs) contribute to the production of over 50% of livestock and poultry in the U.S. Manure is a major source of CAFO-related environmental contamination, including Campylobacter. This study, focusing on high-risk rural, agricultural community populations, will evaluate whether rural residents with greater animal densities near their home or direct animal contact will have higher levels of C. jejuni IgG antibody levels than those living farther way or not having direct contact with animals.

Coleman Award申请审查委员会选择了8位20财年资金的申请人，下一步描述。这些研究表明，NIMHD DIR有能力利用NIH资源进行健康差异研究。 Julia Chen-Sankey博士，MPP，博士后研究员，NIHMD。标题：非洲裔美国年轻人雪茄吸烟的建造和社会文化环境风险因素。 Chen-Sankey博士先前使用烟草人口评估和健康研究调查的研究表明，在20152016之间，非裔美国人年轻人（AAYDS）（18-24岁）的雪茄吸烟几乎是白人年轻人的两倍。这项与40个AAYD的形成性研究将通过对（1）对AAYDS中雪茄吸烟的建筑和社会文化环境风险因素的深入了解，并在Aayds中获得预防和减少努力，以及（2）这些环境风险因素如何影响。来自低等教育背景的AAYD之间的雪茄吸烟不同。 Brittny C. Davis Lynn博士，MPH，研究员/NCI。项目标题：黑人和白人妇女中的母乳微生物组及其与乳腺癌危险因素的关系。已知分子乳腺肿瘤亚型因年龄，种族和种族而有所不同，种族和种族的原因尚不清楚。戴维斯·林恩斯（Davis Lynns）博士先前的工作确定了黑人和白人妇女种族的母乳DNA甲基化和母乳细胞因子水平的差异。 使用NCIS基因组研究中心，拟议的研究将评估乳腺癌危险因素与母乳微生物组之间的关联（n = 400），将危险因子和母乳微生物组数据整合到其他母乳生物标记物（例如DNA甲基化和细胞因子水平）） ，以及黑人和白人妇女之间是否有所不同。 Nicole M. Farmer，医学博士，博士后临床中心国家卫生研究院研究所。项目标题：探索与微生物组相关的饮食代谢产物在心血管疾病健康差异中的作用。非裔美国人（AA）人群患心血管疾病（CVD）的风险增加，饮食与CVD有已知的因果关系，但是，与饮食相关的CVD的确切细胞机制仍然相对未知。这项研究将：1）检查TMAO水平及其与肥胖，CVD风险或居住在华盛顿特区的男性和妇女的压力度量的可能相关性； 2）用TMAO对食物来源进行饮食表型，以检查其在确定CVD风险中的作用；并检查TMAO在人主动脉内皮细胞（HAOEC）功能上的关联。 莎拉·杰克逊（Sarah S. Jackson）博士，M.P.H.，国家癌症研究所博士后研究员。项目名称：试点研究，以识别电子健康记录中的变性人。 跨性别者是指性别认同与出生时分配的性别不同的个人（例如，出生时分配的男性并将其识别为女人），而Cisgender是一个术语，对于那些与性别认同在出生时分配的性别的人（例如，出生时分配男性，并确定为男人）。这项研究的目的是使用电子健康记录中的社会人口统计学，诊断，程序和药物代码来构建和测试算法的初步有效性，这些算法可以在大型医疗记录数据集中识别跨性别的身份。 该算法的有效性将比较算法与自我识别的性别认同的性能作为识别跨性别状态的黄金标准。这项研究利用了美国国立卫生研究院所有人研究的116,460名参与者的数据。 美国国家糖尿病与消化和肾脏疾病研究所的参谋科学家Anup Kumar Nair博士。项目标题：使用IPSCS衍生的胰腺像细胞中的PIMA印第安人中2型糖尿病基因座的功能进行建模。最近，我们一直在获得源自源自PIMA印度血细胞的诱导多能干细胞（IPSC），用于研究T2D相关基因作为药物发现的潜在靶标。拟议的研究将：1）确定在KCNQ1基因座处的效应基因，这引起了GWAS信号； 2）确定每种ISENIC IPSC系的效率以生成胰腺样细胞。 国家儿童健康与人类发展研究所博士后研究员Marion Ouidir博士。项目名称：早期怀孕早期血脂异常的遗传和环境决定因素。血液中总胆固醇，低密度脂蛋白胆固醇（LDLC），高密度脂蛋白胆固醇（HDLC）和血液中甘油三酸酯的异常水平被定义为血管血管疾病的危险因素。由于GWAS主要涉及男性欧洲血统的GWA发现与血脂异常相关的单核苷酸多态性（SNP），因此缺乏有关孕妇的信息，在孕妇中，血脂异常与较高或较低的出生体重Offspring以及美国少数民族有关的孕妇有关这项研究的目的是：1）确定妊娠早期血脂异常的祖先特异性和 - 共享遗传基因座； 2）确定使妇女患有血脂异常的遗传变异体的环境改性剂（例如耶稣降生，感知的压力和肥胖状态）。 Emily L. Rossi博士，M.P.H.，Rony Arauz Melendez，Ph.D.项目名称：遗传血统对欧美和非裔美国人肺癌免疫局势差异的差异。这项研究将比较非洲裔美国和欧美的非涉及邻近组织和肿瘤组织以识别：1）富含肿瘤中的免疫细胞子集； 2）通过遗传血统肿瘤免疫细胞富集和肿瘤浸润的免疫细胞组成的差异； 3）与肿瘤相关的新抗原及其关系该研究将比较非洲裔美国和欧美无涉及的邻近（正常）组织和肿瘤组织以识别：1）富含肿瘤中的免疫细胞子集； 2）通过遗传血统肿瘤免疫细胞富集和肿瘤浸润的免疫细胞组成的差异； 3）与肿瘤相关的新抗原及其与特定肿瘤浸润的免疫细胞亚群和遗传血统的关系。 乔·希勒（Joe Shearer）博士，MPH，博士后研究员，NCI。项目名称：评估集中动物喂养行动对农村农业社区弯曲杆菌感染的影响。浓缩动物喂养行动（CAFO）有助于在美国粪便中生产超过50％的牲畜和家禽，这是包括CAFO相关的环境污染的主要来源，包括弯曲杆菌。这项研究的重点是高危农村，农业社区人口，将评估其家中动物密度更高的农村居民还是直接动物接触的水平比居住在更远的地方或没有直接的动物水平更高。与动物接触。