Dr. William Coleman Award

威廉·科尔曼博士奖

基本信息

批准号：
10020089
负责人：
Anna Maria Napoles
金额：
$ 6.26万
依托单位：
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10020089
关键词：
Address Affect African American American Area Atherosclerosis Autophagocytosis Award Bacteria Biology Blood Blood Cells Blood Vessels Cancer Family Cell Lineage Cell physiology Cells Characteristics Cholesterol Chronic stress Communities Crystal Formation Data Development Disease Doctor of Philosophy Endothelial Cells Environment Environmental Exposure Environmental Health Environmental Risk Factor European Extramural Activities Familial prostate cancer Functional disorder Funding Future Gastritis Genetic Genetic Variation Health Heart Helicobacter Infections Helicobacter pylori Immune Impairment Individual Infection Institutes Intramural Research Program Lipopolysaccharide Biosynthesis Pathway Lung Malignant neoplasm of prostate Mentors Mexican Americans National Human Genome Research Institute National Institute of Drug Abuse National Institute on Aging National Institute on Alcohol Abuse and Alcoholism Neighborhoods Neurobiology Patients Postdoctoral Fellow Recording of previous events Research Research Personnel Research Project Grants Review Committee Scientist Signal Pathway Sleep Sleep disturbances Social Environment Stomach Stress Susceptibility Gene Tissue-Specific Gene Expression Training Ulcer United States National Institutes of Health Visit Washington Work adaptive immune response alcohol use disorder atherogenesis biobehavior cardiometabolism cardiovascular health design ethnic minority population exome exome sequencing health disparity high risk imaging genetics innovation lipid metabolism low socioeconomic status malignant breast neoplasm malignant stomach neoplasm member men minority health negative affect neural circuit novel racial and ethnic racial disparity single-cell RNA sequencing sleep health transcriptome sequencing translational study triple-negative invasive breast carcinoma vascular inflammation

项目摘要

A Coleman award application review committee was convened with members from NIMHD Extramural, DIR, and other ICs. Five applicants were selected for FY19 funding. A description of the recipients and their research projects follows. Yvonne Baumer, Dr. rer. nat (PhD), Staff Scientist, National Heart. Lung, and Blood Institute. Project Title:Elucidating the Impact of Chronic Stress From Social Environment on Endothelial Cell Function and Vascular Biology: A Translational Study to Address Cardiovascular Health Disparities. Researchers aim to determine whether vascular inflammation is a marker of subclinical atherosclerosis that varies among residents of high- and low-SES neighborhoods in Washington, D.C.; whether individuals from low-SES neighborhoods have altered EC lipid metabolism and EC cholesterol crystal formation; and whether patients with stress-related CVD have impaired signaling pathways controlling lysosomal function and autophagy. Researchers also hope to identify novel signaling pathways important to stress-induced atherogenesis and to broaden understanding of how CVD develops and progresses. Jung Shin Byun, PhD, Staff Scientist, National Institute on Minority Health and Health Disparities. Project Title: Single-Cell RNA-Seq to Describe Differences in Immune Cell Profiles Between African American and European American Patients with Triple-Negative Breast Cancer. Using RNA sequencing in African American and European Americans, the researchers aim to identify prevalent differential gene expression in different cell lineages by studying circulating peripheral blood cells and Triplle Negative Breast Cancer infiltrates at the single-cell level. Mehdi Farokhnia, MD and Monica Faulkner, PhD, Post-doctoral Fellows, National Institute on Alcohol Abuse and Alcoholism and National Institute on Drug Abuse. Project Title: Integration of Imaging, Genetics, and Biobehavioral Data to Investigate the Neurobiological Substrates of Racial Disparity Between Black and White Individuals With Alcohol Use Disorder. This project will investigate whether distinct neural circuits and biobehavioral characteristics underlie differences in AUDs development and progression between Black and White individuals, and whether genetic ancestry contributes to neurobiological characterization of racial disparity in relation to AUD. Symielle A. Gaston, PhD, MPH, Postdoctoral Fellow, National Institute on Environmental Health Sciences. Project Title: Identification and Characterization of Environmental Factors Contributing to Disparities in Sleep Health and Cardiometabolic Dysfunction. Members of racial/ethnic minority and low SES groups are more likely than Whites to live in suboptimal sleep environments. Poor sleep can negatively affect cardiometabolic health. Investigators will assess multiple environmental exposures and their relationships with sleep and cardiometabolic health to see if they explain racial/ethnic and SES disparities in poor sleep and cardiometabolic health in the U.S. Deyana Lewis, PhD, MPH, Postdoctoral Visiting Fellow, National Institute on Aging. IRTA Post-doctoral Fellow, National Human Genome Research Institute. Project Title: Whole Exome Sequencing of High Risk African American Prostate Cancer Families. African American (AA) men have the higher rates of prostate cancer (PCa) and are more than twice as likely as men with European ancestry (EA) to die of the disease. Whole exome sequencing (WES) of hereditary prostate cancer (HPC) families can help identify rare susceptibility variants that more often affect AAs. The researchers will sequence exomes to identify genetic variations that contribute to the aggressiveness of PCa in AA men and EAs.

科尔曼奖申请审查委员会由来自 NIMHD 校外、DIR 和其他 IC 的成员组成。五名申请人被选中获得 2019 财年资助。以下是对获奖者及其研究项目的描述。伊冯·鲍默 (Yvonne Baumer)，博士。 nat（博士），国家心脏中心科学家。肺和血液研究所。项目名称：阐明社会环境慢性压力对内皮细胞功能和血管生物学的影响：一项解决心血管健康差异的转化研究。研究人员旨在确定血管炎症是否是亚临床动脉粥样硬化的一个标志，这种标志在华盛顿特区高和低社会经济地位社区的居民中存在差异。来自低SES社区的个体是否改变了EC脂质代谢和EC胆固醇晶体形成；以及压力相关心血管疾病患者控制溶酶体功能和自噬的信号通路是否受损。研究人员还希望找出对应激诱发的动脉粥样硬化重要的新信号通路，并扩大对 CVD 如何发生和进展的理解。 Jung Shin Byun 博士，国家少数族裔健康和健康差异研究所研究员科学家。项目名称：单细胞 RNA 测序来描述非裔美国人和欧洲裔美国三阴性乳腺癌患者之间免疫细胞特征的差异。研究人员利用非洲裔美国人和欧洲裔美国人的 RNA 测序，通过研究循环外周血细胞和单细胞水平的三阴性乳腺癌浸润，确定不同细胞谱系中普遍存在的差异基因表达。 Mehdi Farokhnia 医学博士和 Monica Faulkner 博士是国家酒精滥用和酒精中毒研究所以及国家药物滥用研究所的博士后研究员。项目名称：整合影像、遗传学和生物行为数据来调查患有酒精使用障碍的黑人和白人之间种族差异的神经生物学基础。该项目将研究不同的神经回路和生物行为特征是否是黑人和白人之间 AUD 发展和进展差异的基础，以及遗传血统是否有助于与 AUD 相关的种族差异的神经生物学特征。 Symielle A. Gaston，博士、公共卫生硕士、国家环境健康科学研究所博士后研究员。项目名称：导致睡眠健康和心脏代谢功能差异的环境因素的识别和表征。少数种族/族裔和低社会经济地位群体的成员比白人更有可能生活在次优的睡眠环境中。睡眠不佳会对心脏代谢健康产生负面影响。研究人员将评估多种环境暴露及其与睡眠和心脏代谢健康的关系，看看它们是否可以解释美国睡眠不佳和心脏代谢健康方面的种族/民族和社会经济地位差异。 Deyana Lewis，博士，公共卫生硕士，国家老龄化研究所博士后访问学者。 IRTA 博士后研究员，国家人类基因组研究所。项目名称：高风险非裔美国前列腺癌家族的全外显子组测序。非裔美国人 (AA) 男性患前列腺癌 (PCa) 的几率较高，并且死于该疾病的可能性是欧洲血统 (EA) 男性的两倍多。遗传性前列腺癌 (HPC) 家族的全外显子组测序 (WES) 可以帮助识别更常影响 AA 的罕见易感性变异。研究人员将对外显子组进行测序，以确定导致 AA 男性和 EA 中 PCa 侵袭性的遗传变异。