Lifestyle & Behaviors Core, Vos

生活方式

• 批准号: 10260486
• 负责人: MIRIAM B. VOS
• 金额: $ 10.97万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-10 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10260486
• 关键词: Adult; Area; Awareness; Behavior; Behavior assessment; Biological Process; Cardiopulmonary; Child; Clinic; Clinical; Clinical Investigator; Clinical Research; Collaborations; Collection; Communities; Community Surveys; Consultations; Cystic Fibrosis; Data; Data Analyses; Data Collection; Databases; Diet; Dietary Assessment; Dietary intake; Evaluation; Exercise; Exercise Test; Exercise Tolerance; Experimental Designs; Family; Foundations; Funding; Future; Gases; Goals; Health; Home; Inpatients; Interdisciplinary Study; International; Knowledge; Life; Life Style; Literature; Longevity; Lung diseases; Lung infections; Medical; Metabolic; Methodology; Mission; National Institute of Diabetes and Digestive and Kidney Diseases; Outcome; Outpatients; Performance; Phenotype; Physical activity; Positioning Attribute; Protocols documentation; Quality of life; Research; Research Personnel; Role; Services; Sleep; Surveys; Survival Rate; Testing; Therapeutic Intervention; Training; Translating; Translational Research; Translations; Voice; actigraphy; base; behavior change; behavior measurement; behavioral outcome; biobehavior; clinical investigation; comorbidity; cystic fibrosis patients; cystic fibrosis related diabetes; data dissemination; data warehouse; diet and exercise; exercise capacity; instrument; interest; mortality; neglect; novel; peer; poor sleep; pulmonary function; ranpirnase; sleep behavior; tool; training project

PROJECT SUMMARY – Core 3: Lifestyle and Behaviors Core There have been considerable advances in research and medical therapies for cystic fibrosis (CF); however, therapeutic interventions for non-pulmonary, systemic manifestations have been neglected. Fortunately, the median survival rate in CF is on the rise. Therefore, a paradigm shift to focus on modifiable lifestyle and behavioral outcomes that will enable long-term quality of life in CF is critically needed. Individuals with CF are less physically active than their peers and lower exercise capacity is associated with greater mortality, steeper decline in pulmonary function, and more pulmonary infections. Sleep is an essential, restorative, biologic process crucial for maintaining and optimizing health. Poor sleep in CF has not only been associated with progressive lung disease, but also reduced quality of life and daytime performance. Diet has long been a cornerstone of CF therapy; however, diet quality has not been a focus and its role within the changing landscape of CF or its effects on co-morbidities (such as CF-related diabetes) and long-term health are unknown. The overall goal of the Lifestyle & Behaviors Core (LBC) within the Georgia CF Core Center is to bring advanced methodologies to CF-focused research and to accelerate translational, bio-behavioral research comprised of exercise, physical activity, diet, and sleep outcomes in people with CF. This Core will fill a critical knowledge gap by increasing awareness, educating and disseminating knowledge, and supporting the integration of important lifestyle and behavioral measurements and outcomes into clinical investigations across the lifespan. This will be accomplished by three Aims, as follows: Aim 1. To provide training, project-specific consultation and support for assessing, collecting, and interpreting exercise, physical activity, diet, sleep and behavior change data in CF studies. Aim 2. To enhance the utilization and integration of instruments and tools related to lifestyle and behaviors into clinical and translational research in children and adults with CF. Aim 3. To incorporate extensive phenotyping of lifestyle and behavior outcomes into the longitudinal Georgia CF Data Warehouse hosted by the Core Center. The proposed LBC is unique among the currently funded P30 CF Centers. Successful implementation of this core will enable Center Investigators to undertake research to focus on the interaction of lifestyle and behavioral outcomes that are essential for the control of CF related diabetes, the primary focus of this P30 application, and other comorbidities and conditions within the mission of the NIDDK.

项目摘要 - 核心3：生活方式和行为核心 囊性纤维化研究和医疗疗法（CF）取得了很大进步。 但是，对非肺部，全身表现的治疗干预措施已被忽略。 幸运的是，CF的中位生存率正在上升。因此，范式转向关注 可修改的生活方式和行为成果将使CF长期生活质量是 至关重要的是。患有CF的人的身体活跃不如同龄人，并且运动较低 容量与更大的死亡率，钢铁肺功能下降以及更多有关 肺部感染。睡眠是维持和 优化健康。 CF的睡眠不良不仅与进行性肺部疾病有关，而且还与 还降低了生活质量和白天的表现。饮食长期以来一直是CF疗法的基石； 但是，饮食质量并不是重点及其在不断变化的CF景观中的作用或其作用 关于合并症（例如与CF相关的糖尿病）和长期健康状况尚不清楚。总体目标 佐治亚州CF核心中心内的生活方式与行为核心（LBC）是带来先进的 以CF为重点研究和加速转化，生物行为研究的方法 CF患者完成运动，体育锻炼，饮食和睡眠结局。这个核心将填充 通过提高认识，教育和传播知识以及 支持重要的生活方式和行为衡量和结果的整合 整个生命周期的临床研究。这将由三个目标完成，如下所示： 目的1。提供培训，特定于项目的咨询和支持，以评估，收集， 以及在CF研究中解释运动，体育锻炼，饮食，睡眠和行为改变数据。 目标2。增强与生活方式相关的工具和工具的利用和集成和集成 CF儿童和成人的临床和翻译研究的行为。 目标3。将生活方式和行为结果的广泛表型纳入 核心中心托管的纵向佐治亚州CF数据仓库。 拟议的LBC在当前资助的P30 CF中心中是独一无二的。成功实施 该核心将使中心调查人员能够进行研究以专注于生活方式的相互作用 以及控制与CF相关糖尿病必不可少的行为结果，这是 该P30应用程序以及NIDDK任务内的其他合并症和条件。