Kipiyecipakiciipe "coming home": Establishing clinical cultural neuroscience as a tool for understanding the role of traditional cultural engagement in mitigating substance misuse and disorder

Kipiyecipakiciipe“回家”：建立临床文化神经科学作为理解传统文化参与在减轻药物滥用和疾病中的作用的工具

• 批准号: 10740237
• 负责人: Evan James White
• 金额: $ 117.95万
• 依托单位: LAUREATE INSTITUTE FOR BRAIN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10740237
• 关键词: Address; Adult; American Indians; Area; Awareness; Behavioral; Brain; Categories; Clinical; Cognitive; Collaborations; Communities; Disease; Disparity; Ethnic Origin; Evidence based intervention; Focus Groups; Geographic Distribution; Health; Health Disparities Research; Home; Human; Individual; Inequity; Knowledge; Link; Methods; Modeling; Neurosciences; Persons; Phase; Population; Prevalence; Prevention; Process; Race; Recovery; Religion; Research; Risk; Risk Factors; Role; Sampling; Science; Stimulus; Structure; Substance Use Disorder; Techniques; Tribes; Underserved Population; community based participatory research; community center; community engagement; design; experience; health equity; multimodal neuroimaging; neural; neurobehavioral; novel; racial minority population; resilience; resilience factor; social; social health determinants; substance misuse; substance use treatment; tool

PROJECT SUMMARY Inequities in substance use disorders (SUDs) among American Indian (AI) populations persist despite decades of awareness and research. Advancements in heretofore separate areas of SUD research have (1) underscored the importance of community based and culturally grounded research approaches in AI populations and (2) shown the promise of clinical neuroscience's role in addressing SUD. Merging these approaches through clinical-cultural neuroscience is a missing link in the field which holds large promise for advancing both SUD disparities research in AIs and underserved populations, and the neuroscientific understanding of SUD and recovery more broadly. This proposal integrates Community Based Participatory Research (CBPR) and clinical-neuroscience approaches to better delineate the brain processes that are important for SUD and that are impacted by traditional cultural engagement (TCE). The study aims to leverage the large promise of multimodal neuroimaging techniques as a method for probing TCE using objective markers of brain structure and function. Conceptualization of TCE will be done in collaboration with partners from the Shawnee Tribe (ST). This partnership is critical to the current project as culture comprises a broad category of human experiences common to a group of people and is often conflated with race, ethnicity, geographic distribution, and religion. This complexity has made it difficult to parse the influence of cultural factors and meaningfully incorporate TCE into disease and treatment models. Recently, advances in health disparities research among AI communities have conceptualized features of TCE under the framework of social determinants of health (SDH) to delineate specific risk and resilience factors for SUD. Furthermore, TCE has been supported as protective against and as treatment for SUD. The ST recognizes the impact of historical loss and degradation of cultural practices as a key factor in the prevalence of SUD and is committed to centering community engagement in developing evidence-based intervention and prevention efforts informed by and integrating traditional cultural knowledge and practices. Kipiyeecipsakiciipe “coming home” is a Shawnee word chosen by the ST partners to represent the effort of advancing the science of TCE in mitigating SUD disparities. A community advisory board of Shawnee adults will oversee the design, implementation, and interpretation of the study. A three phased approach will be used to provide a multi-level understanding of TCE as a protective SDH. Phase 1 will consist of focus groups aimed at refining a conceptualization of TCE specific to the ST to provide deep conceptual validity for behavioral probes and stimuli for neural probes of TCE. Phase 2 will examine neural probes of TCE and neurobehavioral and cognitive risk factors for SUD across individuals with varying degrees of TCE as defined by the CAB. Phase 3 will extend results to a sample of individual with SUD and healthy controls. This study will provide a framework for studying analogous cultural factor across other racial minority groups to advance health equity.

项目概要 尽管几十年来，美洲印第安人 (AI) 人群中物质使用障碍 (SUD) 的不平等现象仍然存在 迄今为止，SUD 研究各个领域的进展有 (1) 强调人工智能中基于社区和文化的研究方法的重要性 (2) 展示了临床神经科学在解决 SUD 问题上的作用。 通过临床文化神经科学的方法是该领域缺失的一环，但该领域有着巨大的希望 推进人工智能和服务不足人群的 SUD 差异研究以及神经科学 该提案整合了基于社区的参与性。 研究（CBPR）和临床神经科学方法可以更好地描述大脑过程 对于 SUD 来说很重要，并且受到传统文化参与 (TCE) 的影响。该研究旨在利用这一点。 多模态神经影像技术作为使用客观探测 TCE 的方法的巨大前景 TCE 的概念化将与合作伙伴合作完成。 来自肖尼部落 (ST) 的合作伙伴关系对于当前项目至关重要，因为文化包含广泛的内容。 一群人共有的人类经历类别，通常与种族、民族、 这种复杂性使得分析文化的影响变得困难。 最近，健康领域取得了进展。 人工智能社区之间的差异研究在以下框架下概念化了 TCE 的特征： 健康的社会决定因素 (SDH) 来描述 SUD 的特定风险和复原力因素 此外，TCE。 已被支持作为 SUD 的预防和治疗方法。 ST 认识到历史遗失和文化习俗退化的影响是影响历史的一个关键因素。 SUD 的流行，并致力于集中社区参与制定基于证据的 干预和预防工作以传统文化知识和习俗为基础并加以整合。 Kipiyeecipsakiciipe “coming home” 是 ST 合作伙伴选择的肖尼语单词，代表着 推进 TCE 科学以减少 SUD 差异 肖尼成年人社区咨询委员会。 将采用三阶段方法监督研究的设计、实施和解释。 提供对 TCE 作为保护性 SDH 的多层次理解，第一阶段将由焦点小组组成。 完善针对 ST 的 TCE 概念化，为行为提供深刻的概念有效性 TCE 神经探针的探针和刺激 第二阶段将检查 TCE 的神经探针和神经行为。 以及 CAB 定义的具有不同 TCE 程度的个体的 SUD 认知风险因素。 第三阶段将把结果扩展到患有 SUD 的个体样本和健康对照。 研究其他少数族裔群体的类似文化因素以促进健康公平的框架。