Sibling Assessment in Prevention of Pediatric NAFLD in Hispanic Children

兄弟姐妹评估在预防西班牙裔儿童儿科 NAFLD 中的作用

基本信息

批准号：
10675355
负责人：
MIRIAM B. VOS
金额：
$ 37.01万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-12 至 2026-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10675355
关键词：
9 year old Administrative Supplement Adolescent Adult Affect Age Birth Order Black Populations Cardiovascular Diseases Cause of Death Characteristics Child Childhood diabetes Collaborations Communities Diabetes Mellitus Diabetes prevention Diet Dietary Intervention Disease Education Ethnic Origin Exposure to Family Family history of Family member Fatty Liver Food Funding Future Genetic Glucose Health Promotion Hispanic Hispanic Populations Household Image Insulin Resistance Intervention Intervention Studies Juice Liver diseases Magnetic Resonance Methods Mexican Americans Names Non-Insulin-Dependent Diabetes Mellitus Not Hispanic or Latino Nutritionist Obesity Obesity associated liver disease Overweight Parents Participant Population Prevalence Prevention Prevention Research Randomized Randomized Clinical Trials Reduce health disparities Relative Risks Research Research Support Risk Risk Factors Sampling Studies Siblings Testing United States United States National Institutes of Health Youth age group design diabetes risk disorder prevention disorder risk experience gender difference health disparity high risk improved interest intervention effect knowledge base liver transplantation metabolic phenotype non-alcoholic fatty liver disease pediatric non-alcoholic fatty liver disease prepuberty prevent preventive intervention prospective test recruit response sugar treatment as usual trial comparing

项目摘要

Abstract Nonalcoholic fatty liver disease (NAFLD) is an obesity-associated liver disease that affects an estimated 7 million children in the United States. It is the most common reason for liver transplantation in adults and increases long term risk of diabetes and cardiovascular disease. NAFLD disproportionately affects Hispanic children and is an exceptionally important health disparity. The original R01 study focuses on use of a low sugar diet intervention for prevention of NAFLD in pre-pubertal children. The proposed administrative supplement studies are designed to expand the project to siblings of the primary participant and to add assessment of response of diabetes risk factors to the intervention. The findings will have sustained and significant implications for health promotion in Hispanic children, reduce health disparities, and inform future prevention efforts for children at increased risk of NAFLD and diabetes.

抽象的非酒精性脂肪肝病（NAFLD）是一种与肥胖相关的肝病，影响了美国估计有700万儿童。这是肝脏的最常见原因成人的移植并增加了糖尿病和心血管疾病的长期风险。 NAFLD不成比例地影响西班牙裔儿童，并且是一个非常重要的健康差距。原始的R01研究重点是使用低糖干预措施预防 Nafld在圣母前儿童中。拟议的行政补充研究设计了将项目扩展到主要参与者的兄弟姐妹，并增加评估干预措施的糖尿病风险因素。这些发现将具有持久而重要的对西班牙裔儿童的健康促进的影响，减少健康差异并告知对儿童的未来预防努力，患有NAFLD和糖尿病的风险增加。