Development and Cancer Scientific Program

发展与癌症科学计划

• 批准号: 10260731
• 负责人: STEPHEN X SKAPEK
• 金额: $ 3.5万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-03 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10260731
• 关键词: Biology; Cancer Biology; Cancer Center; Cancer Center Support Grant; Cells; Clinical; Complement; Development; Developmental Biology; Epigenetic Process; Faculty; Funding; Grant; Growth and Development function; Human; Institution; Laboratories; Leadership; Malignant Neoplasms; Manuscripts; Medical center; Mind; NCI-Designated Cancer Center; Organism; Pathogenesis; Peer Review; Physicians; Physiology; Prevention; Productivity; Property; Publications; Research Personnel; Scientist; Structure; Training; Tumor Suppressor Genes; bench to bedside; cancer cell; cancer diagnosis; cancer stem cell; improved; member; programs; recruit; stem cell biology; tumor

Our current understanding of human cancer highlights the importance of aberrant developmental programs in cancer pathogenesis. With this in mind, leadership of the Simmons Cancer Center created the Development and Cancer (DC) Scientific Program as one of its pillars. Program membership continues to reflect efforts to comprehensively reach across the campus by flanking laboratory researchers with physician-scientists. The 34 members drawn from 16 departments include 16 faculty members with formal clinical or clinician-scientist training, perfectly poised to close the gap between the bench and bedside. The DC Program includes investigators from the fields of cancer, stem cell, and developmental biology, exploiting existing strengths and recent recruitments, to tackle the crucial questions that will allow us to improve cancer diagnosis, therapy, and ultimately, prevention. Complementing the other scientific programs in the Cancer Center, DC members investigate the developmentally and evolutionarily conserved ancestral themes that are fundamental to cell and organism growth, development, and physiology, and how these factors influence cancer biology. To cover such diverse developmental properties, DC leaders identified five themes that form the core structure of the program: • Theme 1. Tumor-Stroma Interactions; • Theme 2. Oncogene and Tumor Suppressor Gene Biology; • Theme 3. Cancer Cell Programming; • Theme 4. Epigenetics and Cell Fate; and • Theme 5. Stem Cell Biology. The current NCI ($4.1 million) and total peer-reviewed funding ($24.9 million) nearly doubles the grant funding at the program’s inception in 2009. Critically, several funded projects represent multi-investigator efforts within and beyond our institution. DC Program members have authored 327 peer-reviewed publications since the past review, nearly doubling the productivity for the three years prior to the most recent review. The manuscripts with intra-programmatic (13%) and inter-programmatic (36%) footprints nearly doubled as well, and 24% of them included investigators from other NCI-designated cancer centers.

我们目前对人类癌症的理解凸显了异常发育程序的重要性 考虑到这一点，西蒙斯癌症中心的领导层创建了该开发项目。 癌症 (DC) 科学计划作为其支柱之一。 计划成员资格继续反映了通过侧翼全面覆盖整个校园的努力 来自 16 个部门的 34 名成员包括 16 名实验室研究人员。 受过正式临床或临床医生科学家培训的教职人员，完全准备好缩小与 DC 计划包括来自癌症、干细胞和癌症领域的研究人员。 发育生物学，利用现有优势和最近的招募来解决关键问题 这将使我们能够改善癌症的诊断、治疗，并最终完善预防。 癌症中心的科学项目，DC 成员从发育和进化角度研究 保守的祖先主题对于细胞和有机体的生长、发育和生理学至关重要， 以及这些因素如何影响癌症生物学 为了涵盖这些不同的发育特性，DC 领导者 确定了构成该计划核心结构的五个主题： • 主题1.肿瘤-间质相互作用； • 主题2：癌基因和抑癌基因生物学； • 主题3：癌细胞编程； • 主题 4：表观遗传学和细胞命运；以及 • 主题5。干细胞生物学。 目前的 NCI（410 万美元）和同行评审资金总额（2490 万美元）几乎是赠款资金的两倍 该项目于 2009 年启动。重要的是，几个受资助的项目代表了多个研究人员的努力 自成立以来，DC 计划成员已撰写了 327 篇经过同行评审的出版物。 过去的审查，使最近一次审查之前三年的生产率几乎翻了一番。 程序内（13%）和程序间（36%）足迹的手稿也几乎翻了一番， 其中 24% 包括来自其他 NCI 指定癌症中心的研究人员。