Development and Cancer Scientific Program

发展与癌症科学计划

• 批准号: 10260731
• 负责人: STEPHEN X SKAPEK
• 金额: $ 3.5万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-03 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10260731
• 关键词: Biology; Cancer Biology; Cancer Center; Cancer Center Support Grant; Cells; Clinical; Complement; Development; Developmental Biology; Epigenetic Process; Faculty; Funding; Grant; Growth and Development function; Human; Institution; Laboratories; Leadership; Malignant Neoplasms; Manuscripts; Medical center; Mind; NCI-Designated Cancer Center; Organism; Pathogenesis; Peer Review; Physicians; Physiology; Prevention; Productivity; Property; Publications; Research Personnel; Scientist; Structure; Training; Tumor Suppressor Genes; bench to bedside; cancer cell; cancer diagnosis; cancer stem cell; improved; member; programs; recruit; stem cell biology; tumor

Our current understanding of human cancer highlights the importance of aberrant developmental programs in cancer pathogenesis. With this in mind, leadership of the Simmons Cancer Center created the Development and Cancer (DC) Scientific Program as one of its pillars. Program membership continues to reflect efforts to comprehensively reach across the campus by flanking laboratory researchers with physician-scientists. The 34 members drawn from 16 departments include 16 faculty members with formal clinical or clinician-scientist training, perfectly poised to close the gap between the bench and bedside. The DC Program includes investigators from the fields of cancer, stem cell, and developmental biology, exploiting existing strengths and recent recruitments, to tackle the crucial questions that will allow us to improve cancer diagnosis, therapy, and ultimately, prevention. Complementing the other scientific programs in the Cancer Center, DC members investigate the developmentally and evolutionarily conserved ancestral themes that are fundamental to cell and organism growth, development, and physiology, and how these factors influence cancer biology. To cover such diverse developmental properties, DC leaders identified five themes that form the core structure of the program: • Theme 1. Tumor-Stroma Interactions; • Theme 2. Oncogene and Tumor Suppressor Gene Biology; • Theme 3. Cancer Cell Programming; • Theme 4. Epigenetics and Cell Fate; and • Theme 5. Stem Cell Biology. The current NCI ($4.1 million) and total peer-reviewed funding ($24.9 million) nearly doubles the grant funding at the program’s inception in 2009. Critically, several funded projects represent multi-investigator efforts within and beyond our institution. DC Program members have authored 327 peer-reviewed publications since the past review, nearly doubling the productivity for the three years prior to the most recent review. The manuscripts with intra-programmatic (13%) and inter-programmatic (36%) footprints nearly doubled as well, and 24% of them included investigators from other NCI-designated cancer centers.

我们目前对人类癌症的理解强调了异常发展计划在 癌症发病机理。考虑到这一点，西蒙斯癌症中心的领导创造了发展 和癌症（DC）科学计划是其支柱之一。 计划成员继续反映出通过侧面全面到达整个校园的努力 实验室研究人员与身体科学家。来自16个部门的34名成员包括16个 接受正式临床或临床科学家培训的教职员工，完全中毒，以缩小 长凳和床边。 DC计划包括来自癌症，干细胞和 发展生物学，利用现有优势和最近的新兵，以解决关键问题 这将使我们能够改善癌症诊断，治疗，并最终预防。补充对方 DC成员在癌症中心的科学计划在发育和进化上调查 保守的祖先主题是细胞和生物体生长，发育和生理学基础的重要主题 以及这些因素如何影响癌症生物学。为了涵盖这种潜水的发展特性，DC领导者 确定了构成程序核心结构的五个主题： •主题1。肿瘤的相互作用； •主题2。癌基因和肿瘤抑制基因生物学； •主题3。癌细胞编程； •主题4。表观遗传学和细胞命运；和 •主题5。干细胞生物学。 目前的NCI（410万美元）和同行评审的总资​​金（2490万美元）几乎翻了一番 在该计划的2009年机会中。批判性的是，几个资助的项目代表了多次投资者的努力 超越我们的机构。 DC计划成员已撰写了327个同行评审的出版物 过去的评论，在最近的评论之前的三年中，生产率几乎翻了一番。这 具有前编程（13％）和编程间（36％）足迹的手稿也几乎翻了一番 其中24％包括来自其他NCI指定癌症中心的研究人员。