Development and Cancer Program

发展和癌症计划

• 批准号: 10477964
• 负责人: STEPHEN X SKAPEK
• 金额: $ 2.63万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10477964
• 关键词: Adult; Award; Biological Models; Cancer Biology; Cancer Cell Growth; Cancer Center; Cancer Center Support Grant; Cancer Patient; Caring; Catchment Area; Cell Differentiation process; Cell Survival; Cell division; Cells; Chemistry; Clinic; Clinical; Collaborations; Colorectal; Complement; Comprehensive Cancer Center; Data; Development; Developmental Biology; Developmental Process; Doctor of Philosophy; Elements; Environment; Epigenetic Process; Extracellular Protein; Fostering; Functional disorder; Funding; Gene Expression; Genomics; Goals; Grant; Growth; Guidelines; Homo; Human; Human Development; Investigation; Journals; Kidney; Laboratories; Lead; Light; Liver; Lung; Malignant Childhood Neoplasm; Malignant Neoplasms; Malignant neoplasm of liver; Malignant neoplasm of lung; Medical center; Modeling; Molecular; NCI Center for Cancer Research; Neoplasm Metastasis; Organ; Organism; Organogenesis; Pathogenesis; Pathway interactions; Patients; Peer Review; Physicians; Pilot Projects; Process; Prognostic Marker; Publications; Recurrence; Research; Research Personnel; Resource Sharing; Resources; Role; Scientist; Series; Signal Transduction; Tissues; Work; animal imaging; base; cancer cell; cancer initiation; cell growth; cell regeneration; cell stroma; clinical application; clinical translation; diagnostic biomarker; high throughput screening; improved; improved outcome; lens; live cell imaging; malignant phenotype; member; multidisciplinary; novel diagnostics; novel therapeutic intervention; organ growth; organ regeneration; pre-clinical; programs; stem cell biology; stem cells; tool; translational impact; translational potential; tumor; tumor progression

The Development and Cancer (DC) Program at Simmons Comprehensive Cancer Center (SCCC) is a multidisciplinary program co-led by Joshua Mendell, MD, PhD, and Stephen Skapek, MD. The DC Program includes 41 basic, computational, and physician scientists from 18 departments and centers at UT Southwestern Medical Center (UTSW). The DC Program is unique among SCCC programs in that its members investigate the developmentally and evolutionarily conserved processes that are fundamental to cancer cell growth, division, and differentiation. DC investigators also study the organ and organism growth and developmental processes that are derailed in human cancer. DC Program members pursue four major aims to cover the diversity at the developmental and cancer biology interface: (1) Systematic analyses of stem cell biology and regeneration, (2) Exploring gene expression and cell fate, (3) Studies of cell differentiation and organogenesis, and (4) Analyzing cell–cell and cell–stroma interactions. DC Program Leaders promote utilization of the complete spectrum of resources from SCCC and the Cancer Center Support Grant (CCSG) to provide a research environment that stimulates scientific interactions between laboratory-based investigators and translational and clinical researchers. As a result, DC Program members have fully participated in Kidney and Liver SPORE projects, NCI and CPRIT multi-investigator research awards, and exploration of topics with high potential for clinical translation. Many of these efforts are beginning to reach cancer patients, including those with lung and liver cancer and other malignancies that are particularly prevalent in the SCCC catchment area. Total direct peer-reviewed funding to the DC Program is $16.5M, with 29% from NCI. This represents an increase of $4.5M in peer-reviewed funding compared with 2014 data, which were adjusted to conform to new NCI guidelines. Since 2014, DC Program members have authored 552 publications: 16% represent intraprogrammatic work, 47% are interprogrammatic collaborations, and 30% are in journals with an impact factor >10. DC Program members benefit from the use of all six of the Cancer Center Shared Resources, especially Live Cell Imaging, Small Animal Imaging, and Tissue Management. To foster collaborations, the DC Program holds a large annual retreat, leads relevant campuswide seminar series, and organizes theme-focused research retreats. In addition, DC Program members received $1.5M in pilot project funding during the last grant cycle; those funds have helped to catalyze collaborations and research at the development and cancer biology interface. The program is highly invested in unraveling the fundamental elements of cancer biology in a manner that can ultimately improve the care provided to patients with cancer.

西蒙斯综合癌症中心 (SCCC) 的发育与癌症 (DC) 项目是一个 由医学博士 Joshua Mendell 和医学博士 Stephen Skapek 共同领导的 DC 项目。 包括来自 UT Southwestern 18 个系和中心的 41 名基础科学家、计算科学家和医学科学家 医疗中心 (UTSW)。DC 计划在 SCCC 计划中是独一无二的，因为其成员调查了 发育和进化上保守的过程，对于癌细胞生长、分裂、 DC 研究人员还研究器官和生物体的生长和发育过程。 DC 计划成员追求四个主要目标来覆盖人类癌症的多样性。 发育和癌症生物学接口：(1) 干细胞生物学和再生的系统分析，(2) 探索基因表达和细胞命运，(3) 细胞分化和器官发生研究，以及 (4) 分析 DC 项目领导者促进细胞与细胞以及细胞与基质的相互作用。 SCCC 和癌症中心支持基金 (CCSG) 的资源提供了一个研究环境 刺激实验室研究人员与转化和临床之间的科学互动 因此，DC 计划成员充分参与了 NCI 的肾脏和肝脏 SPORE 项目。 和 CPRIT 多研究者研究奖项，并探索具有高临床转化潜力的主题。 其中许多努力已开始惠及癌症患者，包括患有肺癌、肝癌和其他癌症的患者 SCCC 流域内特别流行的恶性肿瘤的直接同行评审资金总额。 DC 计划的资金为 1650 万美元，其中 29% 来自 NCI，这意味着同行评审资金增加了 450 万美元。 与 2014 年数据相比，自 2014 年起，DC 计划对数据进行了调整以符合新的 NCI 指南。 成员撰写了 552 份出版物：16% 属于计划内工作，47% 属于计划间工作 合作，30% 的期刊影响因子 >10，DC 计划成员受益于使用。 所有六个癌症中心共享资源，特别是活细胞成像、小动物成像和组织 为了促进合作，DC 项目每年举办一次大型务虚会，领导相关校园活动。 研讨会系列，并组织以主题为重点的研究务虚会。此外，DC 计划成员还接受了培训。 上一个赠款周期内提供了 150 万美元的试点项目资金；这些资金有助于促进合作和 该项目在开发和癌症生物学界面的研究上投入了大量资金。 癌症生物学的基本要素，最终可以改善为患者提供的护理 患有癌症。