Development and Cancer Program

发展与癌症计划

• 批准号: 10170614
• 负责人: STEPHEN X SKAPEK
• 金额: $ 2.63万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10170614
• 关键词: Adult; Award; Biological Models; Cancer Biology; Cancer Cell Growth; Cancer Center; Cancer Center Support Grant; Cancer Patient; Caring; Catchment Area; Cell Differentiation process; Cell Survival; Cell division; Cells; Chemistry; Clinic; Clinical; Collaborations; Colorectal; Complement; Comprehensive Cancer Center; Data; Development; Developmental Biology; Developmental Process; Doctor of Philosophy; Elements; Environment; Epigenetic Process; Extracellular Protein; Fostering; Functional disorder; Funding; Gene Expression; Genomics; Goals; Grant; Growth; Guidelines; Homo; Human; Human Development; Investigation; Journals; Kidney; Laboratories; Lead; Light; Liver; Lung; Malignant Childhood Neoplasm; Malignant Neoplasms; Malignant neoplasm of liver; Malignant neoplasm of lung; Medical center; Modeling; Molecular; NCI Center for Cancer Research; Neoplasm Metastasis; Organ; Organism; Organogenesis; Pathogenesis; Pathway interactions; Patients; Peer Review; Physicians; Pilot Projects; Process; Prognostic Marker; Publications; Recurrence; Research; Research Personnel; Resource Sharing; Resources; Role; Scientist; Series; Signal Transduction; Tissues; Work; animal imaging; base; cancer cell; cancer initiation; cell growth; cell regeneration; cell stroma; clinical application; clinical translation; diagnostic biomarker; high throughput screening; improved; improved outcome; lens; live cell imaging; malignant phenotype; member; multidisciplinary; novel diagnostics; novel therapeutic intervention; organ growth; organ regeneration; pre-clinical; programs; stem cell biology; stem cells; tool; translational impact; tumor; tumor progression

The Development and Cancer (DC) Program at Simmons Comprehensive Cancer Center (SCCC) is a multidisciplinary program co-led by Joshua Mendell, MD, PhD, and Stephen Skapek, MD. The DC Program includes 41 basic, computational, and physician scientists from 18 departments and centers at UT Southwestern Medical Center (UTSW). The DC Program is unique among SCCC programs in that its members investigate the developmentally and evolutionarily conserved processes that are fundamental to cancer cell growth, division, and differentiation. DC investigators also study the organ and organism growth and developmental processes that are derailed in human cancer. DC Program members pursue four major aims to cover the diversity at the developmental and cancer biology interface: (1) Systematic analyses of stem cell biology and regeneration, (2) Exploring gene expression and cell fate, (3) Studies of cell differentiation and organogenesis, and (4) Analyzing cell–cell and cell–stroma interactions. DC Program Leaders promote utilization of the complete spectrum of resources from SCCC and the Cancer Center Support Grant (CCSG) to provide a research environment that stimulates scientific interactions between laboratory-based investigators and translational and clinical researchers. As a result, DC Program members have fully participated in Kidney and Liver SPORE projects, NCI and CPRIT multi-investigator research awards, and exploration of topics with high potential for clinical translation. Many of these efforts are beginning to reach cancer patients, including those with lung and liver cancer and other malignancies that are particularly prevalent in the SCCC catchment area. Total direct peer-reviewed funding to the DC Program is $16.5M, with 29% from NCI. This represents an increase of $4.5M in peer-reviewed funding compared with 2014 data, which were adjusted to conform to new NCI guidelines. Since 2014, DC Program members have authored 552 publications: 16% represent intraprogrammatic work, 47% are interprogrammatic collaborations, and 30% are in journals with an impact factor >10. DC Program members benefit from the use of all six of the Cancer Center Shared Resources, especially Live Cell Imaging, Small Animal Imaging, and Tissue Management. To foster collaborations, the DC Program holds a large annual retreat, leads relevant campuswide seminar series, and organizes theme-focused research retreats. In addition, DC Program members received $1.5M in pilot project funding during the last grant cycle; those funds have helped to catalyze collaborations and research at the development and cancer biology interface. The program is highly invested in unraveling the fundamental elements of cancer biology in a manner that can ultimately improve the care provided to patients with cancer.

Simmons综合癌症中心（SCCC）的开发与癌症（DC）计划是 多学科计划由医学博士Joshua Mendell和医学博士的Stephen Skapek共同主持。 DC程序 包括来自UT西南18个部门和中心的41位基本，计算和物理科学家 医疗中心（UTSW）。 DC计划在SCCC计划中是独一无二的，因为其成员研究了 在开发和进化上配置的过程，这些过程对癌细胞生长的基础，分裂， 和分化。 DC研究人员还研究器官和生物体的生长和发育过程 在人类癌症中脱轨。 DC计划成员追求四个主要目标，以涵盖多样性 发育和癌症生物学界面：（1）干细胞生物学和再生的系统分析，（2） 探索基因表达和细胞命运，（3）细胞分化和器官发生的研究，（4）分析 细胞 - 细胞和细胞 - 性质相互作用。 DC计划领导者促进了完整频谱的利用 SCCC和癌症中心支持补助金（CCSG）的资源提供了一个研究环境 刺激基于实验室的研究者与转化和临床之间的科学相互作用 研究人员。结果，DC计划成员已完全参与NCI肾脏和肝脏孢子项目 和CPRIT多入侵者研究奖，以及对临床翻译潜力很高的主题的探索。 这些努力中有许多开始吸引癌症患者，包括肺癌和肝癌以及其他的患者 在SCCC集水区中特别普遍的Malignancys。直接直接同行评审的资金 DC计划为1650万美元，NCI的29％。这表示由同行评审的资金增加了450万美元 与2014年的数据相比，该数据经过调整以符合新的NCI指南。自2014年以来，DC计划 成员已经撰写了552个出版物：16％代表磁内图，有47％是解释性的 协作，30％在影响因素> 10的期刊中。 DC计划成员从使用中受益 所有六个癌症中心共享资源，尤其是活细胞成像，小动物成像和组织 管理。为了促进合作，DC计划举行大型年度务虚会，领导相关的校园 研讨会系列，并组织以主题为中心的研究务虚会。此外，DC计划成员已收到 在上一个赠款周期中，试点项目资金为150万美元；这些资金有助于促进合作和 开发和癌症生物学界面的研究。该计划在阐明 癌症生物学的基本要素，最终可以改善为患者提供的护理 癌症。