Harmonized Diagnostic Assessment of Dementia (DAD) for Longitudinal Aging Surveys in India (LASI)

印度纵向老龄化调查 (LASI) 痴呆症统一诊断评估 (DAD)

• 批准号: 10267745
• 负责人: Jinkook Lee
• 金额: $ 236.61万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-15 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10267745
• 关键词: Adopted; Aerosols; Age; Age-Years; Aging; Air Pollution; American; Android; Auditory system; Biological; Biological Assay; Biology; Biomass; Blood; Brain; British; Cardiovascular system; Caregiver Burden; Caribbean region; Caring; Cellular Phone; Clinical; Clinical assessments; Coal; Cognition; Cognitive; Collection; Communities; Comparative Study; Consensus; Country; Data; Data Set; Dementia; Deterioration; Diagnosis; Diagnostic; Discipline; Economic Burden; Elderly; European; Exhibits; Exposure to; Fundus photography; Generations; Geography; Geriatrics; Goals; Government; Guidelines; Health; Health and Retirement Study; Hearing Tests; Household; Impaired cognition; Impairment; Incidence; Income; India; Individual; Inflammatory; International; Intervention; Interview; Investigation; Journals; Long-Term Care; Longitudinal Studies; Measurement; Measures; Medical; Metabolic; Methodology; Modeling; Monitor; Nature; Optics; Paper; Periodicity; Peripheral; Policies; Population; Population Heterogeneity; Prevention; Protocols documentation; Publishing; Reporting; Research; Research Personnel; Respondent; Retina; Risk Factors; Role; Sampling; Sensory; Serum; Societies; Source; South African; Stress; Surveys; Technology; Testing; Time; Training; Transportation; Venous; Visual; Visual impairment; Work; aged; ambient air pollution; base; biodemography; biological adaptation to stress; care costs; care giving burden; cognitive ability; cognitive change; cognitive testing; cooking; cost; data harmonization; dementia risk; digital; ethnic diversity; fine particles; follow-up; hearing impairment; illiterate; improved; informal caregiver; informant; innovation; insight; interest; recruit; sensor; sensory system; social; sociodemographics; spatiotemporal; tau Proteins; tau-1; webinar

Project Summary The Harmonized Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI-DAD) is the first and only nationally representative and publicly available dataset on late-life cognition and dementia in India. Our overarching goals are to develop a first rate, longitudinal study of late-life cognition and dementia in India and to provide rich, high-quality data to the larger research community to advance our understanding of risk factors of late-life cognitive decline and dementia. Further, we administer the Harmonized Cognitive Assessment Protocol (HCAP), a common set of cognitive test batteries used by an international network of researchers, enabling new and innovative comparative studies across both low- and high-income countries. In this application, we aim to prepare for and collect Wave 2 of LASI-DAD. We will conduct follow up interviews at Wave 2 with all Wave 1 respondents and also recruit newly age-eligible respondents. Using Wave 2 data, we aim to estimate the dementia incidence rate at the population level and to investigate its predictors. We also aim to study cognitive changes and their correlates over the 4-year time period and to estimate the economic and caregiving burden of dementia. LASI-DAD provides an unprecedented opportunity to study key modifiable and non-modifiable risk factors for dementia and late-life cognitive decline. Rich, harmonized data on cognitive tests and informant reports, as well as venous blood assays and geriatric clinical assessments, enable cross-country comparisons of the influence of sociodemographic and biological variables (e.g. cardiovascular, metabolic, and inflammatory factors) on late-life cognition and dementia. For Wave 2, we will further innovate by: (1) expanding our venous blood assays to include total and phosphorylated tau protein in serum; (2) improving the measurement of personal exposure to PM2.5 using mobile sensors and identifying the relative contributions of different air pollution emission sources; (3) improving the hearing test protocol using an Android-based audiometry test; (4) assessing ocular health, including the use of retinal fundus photography; and (5) assessing caregiving burden. Altogether, the findings of the proposed investigation will yield new insights on the risk factors for dementia incidence and cognitive decline, allowing a better understanding of potential targets for dementia prevention in India and other countries around the world. As with Wave 1, we will prepare public use data and a codebook in a timely manner and promote data usage through exhibits, training webinars, and a user help desk, actively building a user base of researchers from across multiple scientific disciplines.

项目摘要 印度纵向老化研究的痴呆症的统一诊断评估（Lasi-dad） 是第一个也是唯一关于晚年认知和痴呆症的全国代表和公开可用的数据集 在印度。我们的总体目标是对后期认知和痴呆症的一流，纵向研究 在印度，并向更大的研究社区提供丰富的高质量数据，以促进我们的理解 晚年认知下降和痴呆症的危险因素。此外，我们管理统一的认知 评估协议（HCAP），这是国际网络使用的一组认知测试电池 研究人员，在低收入国家和高收入国家中实现了新的和创新的比较研究。 在此应用程序中，我们旨在准备并收集Lasi-dad的第2波。我们将进行跟进 在第2浪中，与所有第一波受访者进行了访谈，还招募了新的符合年龄的受访者。使用波 2数据，我们旨在估计人口水平的痴呆发病率并研究其预测因子。 我们还旨在研究认知变化及其在4年期间的相关性，并估算 痴呆症的经济和照料负担。 Lasi-dad提供了一个前所未有的机会来学习钥匙 痴呆和晚期认知能力下降的可修改和不可修改的危险因素。丰富的，统一的数据 关于认知测试和线人报告，以及静脉血测定和老年临床评估， 启用跨国比较社会人口统计学和生物学变量的影响（例如 后期认知和痴呆症的心血管，代谢和炎症因素）。 对于波2， 我们将通过以下方式进一步创新：（1）扩大我们的静脉血测定以包括总和 血清中的磷酸化tau蛋白； （2）使用使用 移动传感器并确定不同空气污染排放源的相对贡献； （3） 使用基于Android的听觉测试改善听力测试协议； （4）评估眼部健康， 包括使用视网膜底摄影； （5）评估护理负担。总共发现 拟议的调查将产生有关痴呆发病率和认知危险因素的新见解 衰落，可以更好地了解印度和其他印度预防痴呆症的潜在靶标 世界各地。与Wave 1一样，我们将及时准备公共使用数据和代码手册 通过展览，培训网络研讨会和用户服务台进行方式并促进数据使用情况，并积极构建 来自多个科学学科的研究人员的用户群。