Project 3

项目3

基本信息

批准号：
10252832
负责人：
ROB S MCCONNELL
金额：
$ 37.53万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-19 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10252832
关键词：
Address Adolescence Adolescent and Young Adult Adopted Adverse effects Aerosols Affect Age Age-Years Behavior Cartoons Characteristics Cigarette Cigarette Smoker Clip Complement Curiosities Data Dependence Development Devices Electronic cigarette Ethnic Origin Experimental Designs Exposure to Health Image Individual Infrastructure Link Marketing Methods Mission Modeling Names Nicotine Nicotine Dependence Outcome Pattern Peptide Initiation Factors Policies Population Population Heterogeneity Positioning Attribute Prospective Studies Public Health Questionnaires Race Regulation Reporting Research Resources Risk Risk Factors Salvelinus Sampling Sex Orientation Smell Perception Smoke Smoker Smoking Status Social Interaction Socioeconomic Status Surveys Taste Perception Testing Tobacco Tobacco use Variant Visual Vulnerable Populations Youth addiction cigarette smoking cohort comparative computerized e-cigarette cessation early adolescence electronic cigarette use electronic cigarette user electronic liquid emerging adulthood follow-up innovation interest never smoker nicotine use non-smoker prospective response sex smoking cessation social media success sweet taste perception tobacco advertising tobacco regulatory science vaping young adult

项目摘要

ABSTRACT: PROJECT 3 (P3) Background: Electronic (e)-cigarettes are the most commonly used tobacco product in adolescents and young adults. E-cigarette use is associated with subsequent cigarette initiation in this population. E-cigarette product diversity (i.e., product characteristics and associated marketing strategies) could be a target for FDA product standards and marketing restrictions to reduce the adverse impact of e-cigarettes in young people. Yet, there has been little evidence on this topic. P3 will test hypothesized e-cigarette product characteristics and marketing strategies that may attract never-smokers and put them at risk for tobacco product use but do not affect the likelihood that young smokers will adopt and switch to e-cigarettes. Such data will inform regulatory policies that meet FDA’s mission to ‘protect the population as a whole.’ Example hypothesized product features that may disproportionately attract never smokers (vs. smokers) include sweet flavors (vs. tobacco or other flavors), de- vices and e-liquid compositions used to generate large aerosol clouds for “vape tricks’ (vs. devices that look and feel like cigarettes), and youth-oriented marketing strategies for e-liquid naming, such as “Kustard Killer,” and packaging with (vs. without) cartoon images. Method: P3 will test these hypotheses in a large Center-wide USC- TCORS cohort (N=6400) overseen by the Population Core. Rich longitudinally collected data, including up to 8 years of cumulative follow-up will span critical developmental windows from 14-24 years of age, during which lifelong tobacco use patterns have historically been established. Aim 1. To investigate the association of: 1a) e- cigarette product diversity with appeal and interest in e-cigarettes, using an innovative within-subject experi- mental design including exposure to still images of products and marketing, and GIFs of vape clouds embedded in computerized survey interface (developed with assistance from the Administrative Core and other projects), 1b) e-cigarette interest with subsequent e-cigarette initiation, and 1c) product marketing exposure via various channels with e-cigarette initiation. Aim 2. To evaluate the association of 2a) e-cigarette initiation with tobacco product use outcomes (i.e., e-cigarette and cigarette progression to regular use, dependence, and cessation), and 2b) e-cigarette product characteristics and marketing exposures (via several channels) with tobacco prod- uct use outcomes. Aim 3. To evaluate whether associations of product characteristics and marketing with out- comes observed in Aims 1 and 2 differ between baseline never-smokers and smokers. Integration with “Inter- sections of Products with Populations” theme: P3 will study a variety of domains of e-cigarette product di- versity that overlap with and complement domains studied by the other USC-TCORS projects. P3 uniquely addresses population diversity in the Center by comparing current smokers while they are still young (age <24) with never-smokers. P3 will also examine differential associations by sex, race/ethnicity, sexual orientation, and socioeconomic status. FDA Scientific domains addressed: Addiction, Behavior, and Marketing.

摘要：项目 3 (P3) 背景：电子烟是青少年最常用的烟草产品成人电子烟的使用与该人群随后开始使用电子烟产品有关。多样性（即产品特性和相关营销策略）可能是 FDA 产品的目标减少电子烟对年轻人的不利影响的标准和营销限制仍然存在。关于这个话题的证据很少，P3将测试突袭电子烟的产品特性和营销。可能会吸引从不吸烟者并使他们面临烟草制品使用风险的策略，但不会影响年轻吸烟者采用并转向电子烟的可能性此类数据将为监管政策提供信息。满足 FDA“保护整个人口”的使命。所利用的产品功能示例不成比例地吸引从不吸烟者（相对于吸烟者）包括甜味（相对于烟草或其他口味）、去烟味用于产生大型气溶胶云以进行“电子烟技巧”的虎钳和电子液体组合物（与外观和外观不同的设备相比）感觉像香烟），以及面向年轻人的电子烟油命名营销策略，例如“Kustard Killer”和带（与不带）卡通图像的包装方法：P3 将在大型 USC 中心范围内测试这些假设。 TCORS 队列 (N=6400) 由 Population Core Rich 纵向收集数据，最多包括 8 个。多年的累积随访将跨越 14 岁至 24 岁的关键发育窗口，在此期间历史上已经确定了终生烟草使用模式目标 1. 调查以下因素之间的关联： 1a) 电子- 香烟产品的多样性对电子烟具有吸引力和兴趣，利用创新的受试者内实验心理设计，包括展示产品和营销的静态图像，以及嵌入的 vape 云 GIF 计算机化调查界面（在行政核心和其他项目的协助下开发）， 1b) 对电子烟的兴趣以及随后的电子烟启动，以及 1c) 通过各种方式进行产品营销曝光目标 2. 评估 2a) 电子烟入门与烟草的关联。产品使用结果（即电子烟和香烟发展到经常使用、依赖和戒烟）， 2b) 电子烟产品特征和烟草产品的营销曝光（通过多种渠道）目标 3. 评估产品特性与营销是否存在关联。目标 1 和 2 中观察到的基线从不吸烟者和吸烟者之间存在差异。 “产品与人群”主题：P3将研究电子烟产品的各个领域与其他 USC-TCORS 项目研究的领域重叠和补充的大学。通过比较年轻时（年龄 <24 岁）的当前吸烟者来解决中心的人口多样性问题 P3 还将检查性别、种族/民族、性取向和不吸烟者之间的差异关联。 FDA 涉及的科学领域：成瘾、行为和营销。