Core AAdministrative and Research Translation

核心 A 行政和研究翻译

• 批准号: 10263535
• 负责人: Veena B. Antony
• 金额: $ 11.24万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-16 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10263535
• 关键词: Address; Aerosols; Affect; Air; Alabama; Appointment; Area; Businesses; COVID-19; COVID-19 pandemic; Caliber; Cellulose; Characteristics; Charge; Chemicals; Chemistry; Collaborations; Communicable Diseases; Communities; Community Healthcare; Complement; Coupled; Data; Data Collection; Development; Disease; Disease Outbreaks; Ecosystem; Electrons; Environment; Equipment; Equipment and Supplies; Evaluation; Face; Feedback; Fiber; Filtration; Funding; Goals; Grant; Health Personnel; Healthcare; Heavy Metals; Housing; Hybrids; Joints; Laboratories; Length; Lignin; Liquid substance; Lung diseases; Manufactured form; Masks; Medical Waste; Methods; Morphology; National Institute of Environmental Health Sciences; Oils; Particulate Matter; Pathway interactions; Persons; Polypropylenes; Porosity; Process; Production; Provider; Questionnaires; Reporting; Risk; Roentgen Rays; Sampling; Scanning Electron Microscopy; Science; Side; Soil; Solid; Spectrum Analysis; Statistical Data Interpretation; Surface; Surveys; Technology; Tennessee; Testing; Textiles; Time; Training; Translational Research; Tube; Universities; Ventilator; Virus; Weight; Width; Work; base; carbon fiber; cost; density; design; face mask; flexibility; improved; infrared spectroscopy; innovation; landfill; medical supply; melting; meter; micropore; patient-level barriers; regenerative; remediation; response; submicron; time use; Address; Aerosols; Affect; Air; Alabama; Appointment; Area; Businesses; COVID-19; COVID-19 pandemic; Caliber; Cellulose; Characteristics; Charge; Chemicals; Chemistry; Collaborations; Communicable Diseases; Communities; Community Healthcare; Complement; Coupled; Data; Data Collection; Development; Disease; Disease Outbreaks; Ecosystem; Electrons; Environment; Equipment; Equipment and Supplies; Evaluation; Face; Feedback; Fiber; Filtration; Funding; Goals; Grant; Health Personnel; Healthcare; Heavy Metals; Housing; Hybrids; Joints; Laboratories; Length; Lignin; Liquid substance; Lung diseases; Manufactured form; Masks; Medical Waste; Methods; Morphology; National Institute of Environmental Health Sciences; Oils; Particulate Matter; Pathway interactions; Persons; Polypropylenes; Porosity; Process; Production; Provider; Questionnaires; Reporting; Risk; Roentgen Rays; Sampling; Scanning Electron Microscopy; Science; Side; Soil; Solid; Spectrum Analysis; Statistical Data Interpretation; Surface; Surveys; Technology; Tennessee; Testing; Textiles; Time; Training; Translational Research; Tube; Universities; Ventilator; Virus; Weight; Width; Work; base; carbon fiber; cost; density; design; face mask; flexibility; improved; infrared spectroscopy; innovation; landfill; medical supply; melting; meter; micropore; patient-level barriers; regenerative; remediation; response; submicron; time use

Our current P42 project (Project 5) deals with natural and recycled fiber materials for filtration targeted toward soil remediation. This supplemental funding request (for Project 5) directly addresses the needs of the growing COVID-19 pandemic, with the base theme of natural fibers as filtration media for personal protection. The rapid spread of the COVID-19 pandemic exponentially increases the risk to the P42 community not only from the soil/air contamination with particulate matter and heavy metals, but now the added risk of the virus. Providing low cost reusable and biodegradable personal protection equipment (PPE) solutions to the community will be of immense value. One of the most needed items are PPE masks not only for the health care provider but the public at large. There is growing use of masks of all make ups and configurations, and their use is going to multiply exponentially. The various federal briefings have emphasized the need for a mask for every person, and over 500 million masks could be worn on daily basis world-wide. Hundreds of millions of N95 masks are in production and use worldwide. For the most part, these are disposed after single use (2-3 times at the most) which will result in gigantic quantities in landfill. This will result in massive detrimental environmental implications for years to come. In this project we propose innovative yet practical science to develop natural fiber (biobased) biodegradable filter materials that will meet the NIOSH standards for N95 filter efficiency (FE). The biobased solution is based on sub-micron regenerative cellulose natural fibers (RNCF) and small amounts of textile grade carbon fiber (TCF) that will be designed for turboelectric charging that impart the interaction to capture and kill the virus(es). The RNCF based filter material will be equally effective in lieu (or complement) of the synthetic polypropylene (PP) based 2 µm diameter, 50 grams per square meter (gsm) filter materials (not biodegradable) currently used in the N95 masks. The work will deliver a tangible full concept to product solution for implementing the RNCF material in reusable masks that the team is already developing. The entire solution will be environmentally friendly, safe and will meet NIOSH standards. The materials developed in this project will be tested against the NIOSH 42 CFR 84 for a minimum 95% filtration efficiency against solid and liquid aerosols that do not contain oil. The product will be disseminated to the P42 ecosystem including the health care providers and the community. The feedback from these groups will be sought in the form of surveys, questionnaires, training and the data will be statistically analyzed and become a part of the main P42 grant. The project is collaborative between The University of Tennessee (UT), Oak Ridge National Laboratory (ORNL), University of Alabama at Birmingham and the P42 community.

我们当前的P42项目（项目5）涉及针对过滤的天然和回收纤维材料 迈向土壤修复。此补充资金要求（项目5）直接解决了 越来越多的Covid-19大流行，其自然纤维作为过滤介质的基本主题是个人保护。 COVID-19大流行的迅速传播成倍增加了P42社区的风险 从特定物质和重金属的土壤/空气污染中，但现在增加了病毒的风险。 向社区提供低成本的可重复使用和可生物降解的个人保护设备（PPE）解决方案 将具有巨大的价值。最需要的物品之一是PPE面具，不仅是医疗保健提供者 但是公众众多。越来越多的化妆和配置的口罩使用，它们的使用正在进行 呈指数倍数。各种联邦政府的简报都强调了每个人都需要面具 全世界每天都可以每天戴上超过5亿个口罩。数亿个N95口罩在 生产和使用全球。在大多数情况下，它们在一次使用后被处置（最多2-3次） 这将导致垃圾填埋场的巨大数量。这将导致巨大的有害环境影响 未来几年。在这个项目中，我们提出了创新而实用的科学来开发天然纤维（生物基纤维） 可生物降解的滤清器材料将符合N95过滤效率的NIOSH标准（FE）。生物基 溶液基于亚微米再生纤维素天然纤维（RNCF）和少量纺织等级 碳纤维（TCF）将设计用于涡轮充电，以捕获和杀死的交互作用 病毒。基于RNCF的过滤材料将同样有效地代替合成（或完成） 基于聚丙烯（PP）直径为2 µm，每平方米50克（GSM）滤清器材料（不可生物降解） 目前在N95口罩中使用。这项工作将为实施产品解决方案提供明显的完整概念 团队已经开发的可重复使用掩盖中的RNCF材料。整个解决方案将是 环保，安全，将符合NIOSH标准。该项目中开发的材料将是 针对NIOSH 42 CFR 84测试，针对固体和液体气溶胶的过滤效率至少为95％ 不包含石油。该产品将被传播到包括医疗保健提供者在内的P42生态系统 和社区。这些小组的反馈将以调查，问卷调查的形式感知到 培训和数据将经过统计分析，并成为主要P42赠款的一部分。该项目是 田纳西大学（UT），橡树岭国家实验室（ORNL）之间的合作 伯明翰的阿拉巴马州和P42社区。