Impact of Airborne Heavy Metals on Lung Disease and the Environment

空气中重金属对肺部疾病和环境的影响

基本信息

批准号：
10560500
负责人：
Veena B. Antony
金额：
$ 128.39万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-03-15 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10560500
关键词：
3-Dimensional Affect African American Air Air Pollution Alabama Amendment Area Arsenic Arts Asthma Authorization documentation Biological Biological Markers Blood Bronchoalveolar Lavage Fluid Cadmium Childhood Asthma Chronic Chronic Obstructive Pulmonary Disease Chronic lung disease Civil Rights Coke Communication Communities County Data Detection Developed Countries Development Disease Engineering Environment Environmental Engineering technology Environmental Exposure Environmental Health Environmental Medicine Environmental Science Epidemiology Equity Excision Exhalation Exposure to Fostering Goals Health Heart Heavy Metals Home Human Hybrids Incidence Industrialization Industry Inhalation Knowledge Lead Link Low income Lower Respiratory Tract Infection Lung Lung diseases Manganese Measures Metal exposure Methodology Methods Mission Modality Molecular National Institute of Environmental Health Sciences Non-Invasive Detection Nose Optics Organoids Pathogenesis Patients Persons Phenotype Physical condensation Poison Pollution Population Post-Translational Protein Processing Predisposition Prevalence Process Public Health Schools Research Resources Respiratory System Risk Risk Factors Role Schools Science Scientist Services Signal Recognition Particle Site Smoking Socioeconomic Status Soil Specimen Steel Study Subject Superfund Surface System Technology Tennessee Toxic Environmental Substances Toxicology Training Programs Translational Research United States United States Environmental Protection Agency Universities Work aerosolized authority biobank biomarker validation chronic respiratory disease cigarette smoke coal-fired power plant college community engagement community partnership cost effective demographics disease phenotype disease registry empowerment human subject improved innovation lung health lung injury medical schools mortality multidisciplinary nano next generation novel programs remediation respiratory health response superfund site synergism tool toxicant

项目摘要

The University of Alabama at Birmingham (UAB) Superfund Research Program (UAB-SRP) will address environmental airborne pollution with heavy metals, and its impact on respiratory health and environmental degradation. The 35th Avenue, North Birmingham superfund site has been proposed by the EPA to be put on the national priorities list. It is located in the heart of downtown Birmingham, Alabama. The Contaminants of Potential Concern, identified by the EPA include cadmium, arsenic and manganese which will be studied in the UAB-SRP. The site is home to nearly 20,000 people and is in close proximity to coke furnaces, steel mills and other industry. The population is predominantly African American; who recall their recent civil rights struggles in Birmingham, AL and request environmental equity as well as answers to their concerns about their respiratory health. The prevalence of chronic lung diseases such as Chronic Obstructive Pulmonary Disease (COPD), Asthma in children and Lower Respiratory Tract Infections (LRTI) is significantly higher in the Affected Area compared to the neighboring Control Area irrespective of smoking, socioeconomic status or demographics. The EPA is in the process of remediating the area, removing soil form several homes since they are recognized to have high arsenic levels. The UAB SRP consists of three biomedical projects and two environmental/ engineering projects that will focus on both human lung health and the health of the environment. All biomedical projects involve direct study of subjects from the Affected Area with a focus on COPD, Asthma and LRTI. The environmental projects include the development and use of an “optical nose” to measure toxicants in the field. Remediation by the use of Nano-Micro hybrid fibrous material for contaminant removal will be studied. Transparent, bidirectional communication with the community is fostered through the community engagement and Administrative/Research Translation cores. This innovative, problem based, solution oriented UAB-SRP will provide a deeper understanding of the health of the environment and directly impact the lung health of the residents of Birmingham, Alabama.

阿拉巴马大学伯明翰大学（UAB）超级基金研究计划（UAB-SRP）将解决环境空气中的污染与重金属及其对呼吸健康和环境的影响降解。 EPA已提议将第35大街，北伯明翰超级基金遗址放置国家优先级列表。它位于阿拉巴马州伯明翰市中心的中心。污染物 EPA确定的潜在关注包括镉，砷和锰将在 UAB-SRP。该网站是近20,000人的家园，靠近可乐炉，钢铁厂和其他行业。人口主要是非裔美国人。谁回忆起他们最近的民权斗争阿拉巴马州伯明翰和请求环境平等以及对他们对呼吸系统的关注的回答健康。慢性肺部疾病的患病率，例如慢性阻塞性肺疾病（COPD），儿童和下呼吸道感染（LRTI）的哮喘在受影响的地区明显更高与邻近控制区域相比，无论吸烟，社会经济地位或人口统计学含量如何。这 EPA正在补救该区域，去除土壤形成几个房屋，因为它们被认为是具有高砷水平。 UAB SRP由三个生物医学项目和两个环境组成/ 工程项目将侧重于人类肺部健康和环境健康。所有生物医学项目涉及对受影响地区的受试者的直接研究，重点是COPD，哮喘和LRTI。这环境项目包括开发和使用“光鼻”来测量该领域的毒性。通过使用纳米微杂交纤维材料进行污染物去除的修复将进行研究。通过社区参与来促进与社区透明的双向交流和行政/研究翻译核心。这种创新的，基于问题的，以解决方案为导向的UAB-SRP将深入了解环境的健康，并直接影响阿拉巴马州伯明翰的居民。