Impact of Airborne Heavy Metals on Lung Disease and the Environment
空气中重金属对肺部疾病和环境的影响
基本信息
- 批准号:10560500
- 负责人:
- 金额:$ 128.39万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-03-15 至 2025-01-31
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAffectAfrican AmericanAirAir PollutionAlabamaAmendmentAreaArsenicArtsAsthmaAuthorization documentationBiologicalBiological MarkersBloodBronchoalveolar Lavage FluidCadmiumChildhood AsthmaChronicChronic Obstructive Pulmonary DiseaseChronic lung diseaseCivil RightsCokeCommunicationCommunitiesCountyDataDetectionDeveloped CountriesDevelopmentDiseaseEngineeringEnvironmentEnvironmental Engineering technologyEnvironmental ExposureEnvironmental HealthEnvironmental MedicineEnvironmental ScienceEpidemiologyEquityExcisionExhalationExposure toFosteringGoalsHealthHeartHeavy MetalsHomeHumanHybridsIncidenceIndustrializationIndustryInhalationKnowledgeLeadLinkLow incomeLower Respiratory Tract InfectionLungLung diseasesManganeseMeasuresMetal exposureMethodologyMethodsMissionModalityMolecularNational Institute of Environmental Health SciencesNon-Invasive DetectionNoseOpticsOrganoidsPathogenesisPatientsPersonsPhenotypePhysical condensationPoisonPollutionPopulationPost-Translational Protein ProcessingPredispositionPrevalenceProcessPublic Health SchoolsResearchResourcesRespiratory SystemRiskRisk FactorsRoleSchoolsScienceScientistServicesSignal Recognition ParticleSiteSmokingSocioeconomic StatusSoilSpecimenSteelStudy SubjectSuperfundSurfaceSystemTechnologyTennesseeToxic Environmental SubstancesToxicologyTraining ProgramsTranslational ResearchUnited StatesUnited States Environmental Protection AgencyUniversitiesWorkaerosolizedauthoritybiobankbiomarker validationchronic respiratory diseasecigarette smokecoal-fired power plantcollegecommunity engagementcommunity partnershipcost effectivedemographicsdisease phenotypedisease registryempowermenthuman subjectimprovedinnovationlung healthlung injurymedical schoolsmortalitymultidisciplinarynanonext generationnovelprogramsremediationrespiratory healthresponsesuperfund sitesynergismtooltoxicant
项目摘要
The University of Alabama at Birmingham (UAB) Superfund Research Program (UAB-SRP) will address
environmental airborne pollution with heavy metals, and its impact on respiratory health and environmental
degradation. The 35th Avenue, North Birmingham superfund site has been proposed by the EPA to be put on
the national priorities list. It is located in the heart of downtown Birmingham, Alabama. The Contaminants of
Potential Concern, identified by the EPA include cadmium, arsenic and manganese which will be studied in the
UAB-SRP. The site is home to nearly 20,000 people and is in close proximity to coke furnaces, steel mills and
other industry. The population is predominantly African American; who recall their recent civil rights struggles in
Birmingham, AL and request environmental equity as well as answers to their concerns about their respiratory
health. The prevalence of chronic lung diseases such as Chronic Obstructive Pulmonary Disease (COPD),
Asthma in children and Lower Respiratory Tract Infections (LRTI) is significantly higher in the Affected Area
compared to the neighboring Control Area irrespective of smoking, socioeconomic status or demographics. The
EPA is in the process of remediating the area, removing soil form several homes since they are recognized to
have high arsenic levels. The UAB SRP consists of three biomedical projects and two environmental/
engineering projects that will focus on both human lung health and the health of the environment. All biomedical
projects involve direct study of subjects from the Affected Area with a focus on COPD, Asthma and LRTI. The
environmental projects include the development and use of an “optical nose” to measure toxicants in the field.
Remediation by the use of Nano-Micro hybrid fibrous material for contaminant removal will be studied.
Transparent, bidirectional communication with the community is fostered through the community engagement
and Administrative/Research Translation cores. This innovative, problem based, solution oriented UAB-SRP will
provide a deeper understanding of the health of the environment and directly impact the lung health of the
residents of Birmingham, Alabama.
阿拉巴马大学伯明翰分校 (UAB) 超级基金研究计划 (UAB-SRP) 将解决
环境空气中的重金属污染及其对呼吸系统健康和环境的影响
EPA 提议对北伯明翰第 35 大道超级基金场地进行退化改造。
它位于阿拉巴马州伯明翰市中心的污染物。
EPA 确定的潜在问题包括镉、砷和锰,将在
UAB-SRP 拥有近 20,000 名居民,靠近焦炉、钢厂和
其他行业的人口主要是非裔美国人;他们记得最近的民权斗争。
阿拉巴马州伯明翰市要求环境公平并解答他们对呼吸系统的担忧
慢性阻塞性肺疾病(COPD)等慢性肺部疾病的患病率,
受影响地区的儿童哮喘和下呼吸道感染 (LRTI) 明显较高
与邻近控制区相比,无论吸烟情况、社会经济地位或人口统计情况如何。
环保局正在对该地区进行修复,清除几处房屋的土壤,因为人们认为这些房屋
UAB SRP 包括三个生物医学项目和两个环境/环境项目。
将重点关注人类肺部健康和环境健康的工程项目 所有生物医学。
项目涉及对受影响地区受试者的直接研究,重点是慢性阻塞性肺病、哮喘和 LRTI。
环境项目包括开发和使用“光学鼻子”来测量现场有毒物质。
将研究使用纳米-微米混合纤维材料去除污染物的修复方法。
通过社区参与促进与社区的透明、双向沟通
这个创新的、以问题为基础、以解决方案为导向的 UAB-SRP 将
提供对环境健康的更深入了解,并直接影响人们的肺部健康
阿拉巴马州伯明翰的居民。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Veena B. Antony其他文献
Testing the Waters: Differentiating Transudates From Exudates
试水:区分渗出液和渗出液
- DOI:
10.1378/chest.108.5.1191 - 发表时间:
1995 - 期刊:
- 影响因子:9.6
- 作者:
Veena B. Antony;Kristin A. Holm - 通讯作者:
Kristin A. Holm
Veena B. Antony的其他文献
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{{ truncateString('Veena B. Antony', 18)}}的其他基金
Impact of Airborne Heavy Metals on Lung Disease and the Environment
空气中重金属对肺部疾病和环境的影响
- 批准号:
10263534 - 财政年份:2020
- 资助金额:
$ 128.39万 - 项目类别:
Core A Administrative and Research Translation
核心 A 行政和研究翻译
- 批准号:
10560501 - 财政年份:2020
- 资助金额:
$ 128.39万 - 项目类别:
Core A Administrative and Research Translation
核心 A 行政和研究翻译
- 批准号:
10337081 - 财政年份:2020
- 资助金额:
$ 128.39万 - 项目类别:
Project 1 Heavy Metal Induced Airway Remodeling and COPD
项目1 重金属诱导气道重塑与COPD
- 批准号:
10337087 - 财政年份:2020
- 资助金额:
$ 128.39万 - 项目类别:
Impact of Airborne Heavy Metals on Lung Disease and the Environment
空气中重金属对肺部疾病和环境的影响
- 批准号:
10337080 - 财政年份:2020
- 资助金额:
$ 128.39万 - 项目类别:
Project 1 Heavy Metal Induced Airway Remodeling and COPD
项目1 重金属诱导气道重塑与COPD
- 批准号:
10560528 - 财政年份:2020
- 资助金额:
$ 128.39万 - 项目类别:
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