Louisiana Clinical and Translational Science Center

路易斯安那州临床和转化科学中心

基本信息

批准号：
10258534
负责人：
JOHN P. KIRWAN
金额：
$ 96.2万
依托单位：
LSU PENNINGTON BIOMEDICAL RESEARCH CTR
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-11-17 至 2021-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10258534
关键词：
2019-nCoV Achievement Address Adult Affect African American Age Attitude Award Bioinformatics Biomedical Research Body Weight decreased Body mass index COVID-19 COVID-19 mortality COVID-19 pandemic COVID-19 testing COVID-19 vaccine Center for Translational Science Activities Centers for Disease Control and Prevention (U.S.)Cessation of life Chronic Church Cities Clinic Clinical Sciences Code Collaborations Communication Communities Community Participation Coordination and Collaboration Data Data Reporting Development Diabetes Mellitus Effectiveness Emergency Situation Employment Employment Status FDA Emergency Use Authorization Flu virus Focus Groups Foundations Future Grant Health Health Status Hospitals Human Hypertension Immunization Programs Infrastructure Journals Lead Louisiana Low income Medical Medicine Mission Multimedia Neighborhoods New England Obesity Outcome Patients Perception Policies Polymerase Chain Reaction Population Positioning Attribute Premature Mortality Prevalence Study Public Health Publications RADx Underserved Populations Race Reporting Research Project Grants Resources Reverse Transcription Schools Site Societies Socioeconomic Status South American System Testing Therapeutic Translational Research Underserved Population Virus Vulnerable Populations Work base community based participatory research community based research community center community clinic community engaged research community engagement comorbidity data sharing disparity reduction distrust experience falls health disparity health economics improved low socioeconomic status novel primary outcome response saliva sample service organization sex social health determinants success testing access testing uptake uptake urban underserved

项目摘要

Project Summary/Abstract In the US, COVID-19 has unveiled a disproportionate health burden in low income and underserved segments of society. In Louisiana, some of the greatest health and economic consequences are evident in our Black communities. There is an urgent need to establish effective testing strategies in these communities as the Fall/Winter virus surges unfold. The Louisiana Clinical and Translational Science (LA CaTS) Center provides the essential infrastructure and key foundational support for biomedical research in our region and is uniquely positioned to lead a community-engaged testing research project to determine differences in COVID-19 testing rates between community-based (churches, community centers, and schools) and medical clinic-based testing sites, and determine approaches that will increase uptake of testing in underserved Black communities in the South. We plan to address these issues using a two-pronged approach. First, we will use a community based participatory research approach to determine differences in SARS-CoV-2 testing rates across distinct types of test sites within five urban underserved Black communities in the American South. We will use a multimedia campaign to promote and conduct RT-PCR testing on salivary samples obtained from 2,000 adults at 1) medical clinics, 2) schools, 3) community centers, and 4) churches (in random order) within five ZIP codes with known low socioeconomic status (SES) and a high representation of Black residents. The primary outcome will be the number of tests performed at each type of test site. We will collect information on age, sex, race, BMI, employment, social determinants of health using an aggregate SES score to identify important correlates of testing rates. Second, we will further leverage our strong and well-integrated partnership with the Baton Rouge Mayor's Healthy City Initiative together with our LA CaTS Community Advisory Boards (CABs) to conduct community-based focus groups to obtain qualitative data about the perceptions and attitudes related to testing access and potential barriers affecting such. We will use this information to determine community-driven approaches that are effective in reducing barriers and create strategies to increase SARS-CoV-2 testing uptake in urban underserved Black communities. Results of this project will greatly increase our understanding of the factors that have led to a disproportionate COVID-19 health burden in these underserved populations and lay the groundwork for developing strategies to reduce these disparities in all underserved Black communities. Resulting data will inform the equitable deployment of future virus/flu testing and a SARS-CoV-2 vaccine.

项目概要/摘要在美国，COVID-19 给低收入和服务不足的群体带来了不成比例的健康负担社会的。在路易斯安那州，一些最严重的健康和经济后果在我们的黑人中显而易见社区。迫切需要在这些社区建立有效的检测策略，因为秋冬病毒激增。路易斯安那州临床和转化科学 (LA CaTS) 中心提供我们地区生物医学研究的重要基础设施和关键基础支持，是独一无二的负责领导一个社区参与的测试研究项目，以确定 COVID-19 测试的差异基于社区（教堂、社区中心和学校）和基于医疗诊所的检测之间的比率站点，并确定增加服务不足的黑人社区接受检测的方法南。我们计划采用双管齐下的方法来解决这些问题。首先，我们将使用基于社区的参与式研究方法，以确定不同地区 SARS-CoV-2 检测率的差异美国南部五个服务不足的城市黑人社区内的各种测试地点。我们将使用一项多媒体活动，旨在促进对 2,000 人的唾液样本进行 RT-PCR 检测 1) 医疗诊所、2) 学校、3) 社区中心和 4) 教堂（随机顺序）五天内的成人已知社会经济地位 (SES) 较低且黑人居民比例较高的邮政编码。这主要结果将是在每种类型的测试地点进行的测试数量。我们将收集以下信息使用 SES 总分来识别年龄、性别、种族、BMI、就业、健康的社会决定因素测试率的重要相关性。二是进一步发挥综合实力与巴吞鲁日市长健康城市倡议以及我们的 LA CatS 社区合作咨询委员会 (CAB) 开展以社区为基础的焦点小组，以获得有关与检测准入相关的看法和态度以及影响其的潜在障碍。我们将使用这个确定社区驱动的方法的信息，这些方法可有效减少障碍并创造提高服务不足的城市黑人社区 SARS-CoV-2 检测率的策略。结果该项目将极大地增进我们对导致 COVID-19 不成比例的因素的了解减轻这些服务不足人群的健康负担，并为制定减少疾病负担的战略奠定基础所有服务不足的黑人社区都存在这些差异。由此产生的数据将为公平部署提供信息未来的病毒/流感检测和 SARS-CoV-2 疫苗。