Louisiana Clinical and Translational Science Center

路易斯安那州临床和转化科学中心

• 批准号: 10258534
• 负责人: JOHN P. KIRWAN
• 金额: $ 96.2万
• 依托单位: LSU PENNINGTON BIOMEDICAL RESEARCH CTR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-11-17 至 2021-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10258534
• 关键词: 2019-nCoV; Achievement; Address; Adult; Affect; African American; Age; Attitude; Award; Bioinformatics; Biomedical Research; Body Weight decreased; Body mass index; COVID-19; COVID-19 mortality; COVID-19 pandemic; COVID-19 testing; COVID-19 vaccine; Center for Translational Science Activities; Centers for Disease Control and Prevention (U.S.); Cessation of life; Chronic; Church; Cities; Clinic; Clinical Sciences; Code; Collaborations; Communication; Communities; Community Participation; Coordination and Collaboration; Data; Data Reporting; Development; Diabetes Mellitus; Effectiveness; Emergency Situation; Employment; Employment Status; FDA Emergency Use Authorization; Flu virus; Focus Groups; Foundations; Future; Grant; Health; Health Status; Hospitals; Human; Hypertension; Immunization Programs; Infrastructure; Journals; Lead; Louisiana; Low income; Medical; Medicine; Mission; Multimedia; Neighborhoods; New England; Obesity; Outcome; Patients; Perception; Policies; Polymerase Chain Reaction; Population; Positioning Attribute; Premature Mortality; Prevalence Study; Public Health; Publications; RADx Underserved Populations; Race; Reporting; Research Project Grants; Resources; Reverse Transcription; Schools; Site; Societies; Socioeconomic Status; South American; System; Testing; Therapeutic; Translational Research; Underserved Population; Virus; Vulnerable Populations; Work; base; community based participatory research; community based research; community center; community clinic; community engaged research; community engagement; comorbidity; data sharing; disparity reduction; distrust; experience; falls; health disparity; health economics; improved; low socioeconomic status; novel; primary outcome; response; saliva sample; service organization; sex; social health determinants; success; testing access; testing uptake; uptake; urban underserved

Project Summary/Abstract In the US, COVID-19 has unveiled a disproportionate health burden in low income and underserved segments of society. In Louisiana, some of the greatest health and economic consequences are evident in our Black communities. There is an urgent need to establish effective testing strategies in these communities as the Fall/Winter virus surges unfold. The Louisiana Clinical and Translational Science (LA CaTS) Center provides the essential infrastructure and key foundational support for biomedical research in our region and is uniquely positioned to lead a community-engaged testing research project to determine differences in COVID-19 testing rates between community-based (churches, community centers, and schools) and medical clinic-based testing sites, and determine approaches that will increase uptake of testing in underserved Black communities in the South. We plan to address these issues using a two-pronged approach. First, we will use a community based participatory research approach to determine differences in SARS-CoV-2 testing rates across distinct types of test sites within five urban underserved Black communities in the American South. We will use a multimedia campaign to promote and conduct RT-PCR testing on salivary samples obtained from 2,000 adults at 1) medical clinics, 2) schools, 3) community centers, and 4) churches (in random order) within five ZIP codes with known low socioeconomic status (SES) and a high representation of Black residents. The primary outcome will be the number of tests performed at each type of test site. We will collect information on age, sex, race, BMI, employment, social determinants of health using an aggregate SES score to identify important correlates of testing rates. Second, we will further leverage our strong and well-integrated partnership with the Baton Rouge Mayor's Healthy City Initiative together with our LA CaTS Community Advisory Boards (CABs) to conduct community-based focus groups to obtain qualitative data about the perceptions and attitudes related to testing access and potential barriers affecting such. We will use this information to determine community-driven approaches that are effective in reducing barriers and create strategies to increase SARS-CoV-2 testing uptake in urban underserved Black communities. Results of this project will greatly increase our understanding of the factors that have led to a disproportionate COVID-19 health burden in these underserved populations and lay the groundwork for developing strategies to reduce these disparities in all underserved Black communities. Resulting data will inform the equitable deployment of future virus/flu testing and a SARS-CoV-2 vaccine.

项目摘要/摘要 在美国，Covid-19揭开了低收入和服务不足的健康负担不成比例的 社会。在路易斯安那州，我们的黑人有一些最大的健康和经济后果很明显 社区。迫切需要在这些社区建立有效的测试策略作为 秋季/冬季病毒涌现。路易斯安那州临床和转化科学（LA CATS）中心提供 我们地区生物医学研究的基本基础设施和关键基础支持是独特的 定位领导社区参与的测试研究项目，以确定COVID-19测试的差异 基于社区（教堂，社区中心和学校）和基于医疗诊所的测试之间的速度 站点，并确定将增加在服务不足的黑人社区中进行测试的方法 南。我们计划使用两管齐下的方法来解决这些问题。首先，我们将使用基于社区的 参与性研究方法，以确定SARS-COV-2测试率差异的不同 美国南部五个城市服务不足的黑人社区中的测试地点类型。我们将使用 一项多媒体运动，旨在促进和进行对来自2,000的唾液样本的RT-PCR测试 1）医疗诊所的成人，2）学校，3）社区中心和4）教堂（随机顺序）五个 具有已知低社会经济状况（SES）和黑人居民高度代表的邮政编码。这 主要结果将是每种测试站点进行的测试数量。我们将收集有关 年龄，性别，种族，BMI，就业，健康决定因素，使用总分数来识别 测试率的重要相关性。其次，我们将进一步利用我们强大而良好的 与巴吞鲁日市长的健康城市倡议与我们的洛杉矶猫社区合作 咨询委员会（CABS）进行基于社区的焦点小组，以获取有关 与测试访问和影响此类的潜在障碍有关的看法和态度。我们将使用这个 信息以确定有效减少障碍并创建有效的社区驱动方法 在城市服务不足的黑人社区中增加SARS-COV-2测试吸收的策略。结果 该项目将大大增加我们对导致不成比例的Covid-19的因素的理解 这些服务不足的人群中的健康负担，并为制定减少策略奠定了基础 所有服务不足的黑人社区中的这些差异。结果数据将为公平部署提供 未来的病毒/流感测试和SARS-COV-2疫苗。