Louisiana Clinical and Translational Science Center - N3C supplement

路易斯安那临床和转化科学中心 - N3C 补充品

• 批准号: 10884657
• 负责人: JOHN P. KIRWAN
• 金额: $ 34.67万
• 依托单位: LSU PENNINGTON BIOMEDICAL RESEARCH CTR
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10884657
• 关键词: 2019-nCoV; Academic Medical Centers; Accreditation; Acute; Address; Administrative Supplement; Alabama; Applications Grants; Award; Big Data; Biomedical Research; Black race; COVID testing; COVID-19; COVID-19 pandemic; Case Study; Center for Translational Science Activities; Cessation of life; Clinical; Clinical Data; Clinical Research; Clinical Sciences; Collaborations; Communities; Country; Data; Disease; Disparity; Dose; Eligibility Determination; Evolution; Future; Genomics; Grant; Growth; Health; Health Personnel; Health Sciences; Healthcare Systems; Hospitalization; Hurricane; Individual; Infection; Inosine Dialdehyde; Institution; Institutional Review Boards; Investments; Knowledge; Laboratories; Link; Long COVID; Louisiana; Mississippi; Modeling; Monitor; Outcome; Patients; Pediatric Hospitals; Pharmaceutical Preparations; Population; Positioning Attribute; Post-Acute Sequelae of SARS-CoV-2 Infection; Productivity; Public Health; Publications; RADx Underserved Populations; Records; Reporting; Research; Research Infrastructure; Research Personnel; Resources; Risk; Risk Factors; School Dentistry; Services; Source; System; T-Lymphocyte Epitopes; Time; Translational Research; Trust; United States Department of Veterans Affairs; Universities; Vaccinated; Vaccination; Vaccinee; Variant; Veterans; Viral; Vulnerable Populations; West Virginia; Work; Writing; Wyoming; biomedical informatics; breakthrough infection; clinical epidemiology; clinical risk; clinical translation; cohort; collaboratory; computable phenotypes; coronavirus disease; data enclave; experience; genetic epidemiology; genomic data; health data; health disparity; home test; improved; individual patient; pandemic disease; programs; self testing; transmission process; unvaccinated; viral genomics; viral transmission

Project Summary/Abstract The Louisiana Clinical and Translational Science (LA CaTS) Center is a consortium of the major academic and biomedical research centers in the State of Louisiana. Pennington Biomedical Research Center is the lead institution and will continue to partner with Louisiana State University Health (LSUH)-New Orleans and Tulane University Health Sciences Center in this initiative. LSUH-Shreveport, LSU-A&M (Baton Rouge), Xavier University and Children's Hospital New Orleans, were early Research Partners in cycle 1. Southeast Louisiana Veterans Healthcare System, a newly opened University Medical Center in New Orleans ($1 billion State investment), Ochsner Health and the LSUH-NO School of Dentistry joined during cycle 2. The LA CaTS Center is growing a unified clinical translational science program for Louisiana based on the creation of synergistic programs and unparalleled collaboration from all the major academic and biomedical research institutions in the state. Since inception 9 years ago, the LA CaTS Center has: 1) successfully leveraged resources and expertise of multiple participating institutions to build a vibrant statewide research infrastructure; 2) developed highly synergistic and integrative collaborative programs; 3) implemented a systematic approach to clinical research across all institutions, that includes a new SMART IRB Reliance Model review; and 4) implemented a highly effective governance system based on an unprecedented level of trust between partners. LA CaTS is experiencing exponential growth in research productivity as assessed by key metrics including a three-fold increase in external grant awards, a more than two-fold increase in publications with authors acknowledging LA CaTS Center resources and services and over 600 researchers benefiting from and using our services. Notably, during a period that has been marked by unique and unprecedented challenges from COVID and then Hurricane Ida, LA CaTS has achieved, and in many cases exceeded, its stated objectives and projected milestones. Indeed, since the COVID pandemic hit Louisiana in March of 2020, LA CaTS has led multiple successful grant applications for Administrative Supplements and NOSI awards, notably to facilitate COVID testing and vaccinations in underserved Black communities through the RADx-UP program and most recently our partnership with the IDeA state ISCORE consortium on the national Long-COVID initiative - Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)/RECOVER trial. However, we fully recognize that our work has only just begun, as we collectively address disparities and improve the lives of our citizens. It is also apparent, that slowly, but surely, we are impacting public health one project at a time! With new services proposed and the additional resources that will be added, our Center is uniquely positioned to devote our activities and resources to our major theme for the next 5- year cycle that will “address health disparities and improve the health outcomes of the citizens we serve”

项目概要/摘要 路易斯安那州临床和转化科学 (LA CaTS) 中心是一个由主要学术机构组成的联盟 彭宁顿生物医学研究中心是路易斯安那州的生物医学研究中心。 领导机构并将继续与路易斯安那州立大学健康学院 (LSUH)-新奥尔良分校合作 和杜兰大学健康科学中心参与这项倡议。 Rouge）、泽维尔大学和新奥尔良儿童医院是第一轮的早期研究合作伙伴。 路易斯安那州东南部退伍军人医疗保健系统，新开设的大学医疗中心 奥尔良（国家投资 10 亿美元）、Ochsner Health 和 LSUH-NO 牙科学院加入 第 2 周期。LA CatS 中心正在为路易斯安那州制定统一的临床转化科学计划 基于协同计划的创建和所有主要机构的无与伦比的合作 LA CatS 自 9 年前成立以来，一直是该州的学术和生物医学研究机构。 中心已：1）成功地利用多个参与机构的资源和专业知识 建立充满活力的本土研究基础设施；2）发展高度协同和一体化的研究基础设施； 3）在所有机构中实施系统的临床研究方法； 其中包括新的 SMART IRB 信赖模型审查；以及 4) 实施了高效的 LA CatS 正在经历基于合作伙伴之间前所未有的信任水平的治理系统。 通过关键指标评估，研究生产力呈指数增长，包括三倍增长 外部资助奖励，作者令人信服的出版物数量增加两倍以上 CatS 中心的资源和服务以及 600 多名研究人员受益于并使用我们的服务。 值得注意的是，在新冠疫情带来独特且前所未有的挑战的时期 然后飓风艾达，洛杉矶 CatS 实现了并且在许多情况下超出了其既定目标 事实上，自 2020 年 3 月新冠疫情袭击路易斯安那州以来，LA CatS 一直处于领先地位。 多次成功申请行政补助和 NOSI 奖项，值得注意的是 通过 RADx-UP 促进服务不足的黑人社区的新冠病毒检测和疫苗接种 计划以及最近我们与 IDeA 州 ISCORE 联盟在国家 长期新冠肺炎倡议 - SARS-CoV-2 感染的急性后遗症 (PASC)/RECOVER 试验。 充分认识到我们的工作才刚刚开始，我们正在共同解决差距并改善 同样明显的是，我们正在缓慢但肯定地影响着公共健康。 随着新服务的提出以及将添加的额外资源，我们的 中心处于独特的地位，可以将我们的活动和资源投入到未来 5-5 年的主要主题中。 年周期将“解决健康差距并改善我们公民的健康结果” 服务”

项目成果

Feature selection algorithms enhance the accuracy of frailty indexes as measures of biological age.

• DOI: 10.1093/gerona/glab018
• 发表时间: 2021-01
• 期刊: The journals of gerontology. Series A, Biological sciences and medical sciences
• 作者: PhD Sangkyu Kim;MSc Jessica Fuselier;MD David A. Welsh;K. Cherry;PhD Leann Myers;PhD S. Michal Jazwinski-PhD-S.-Michal-Jaz

Economic Evaluation of the $35 Insulin Copay Cap Policy in Medicare and Its Implication for Future Interventions.

• DOI: 10.2337/dc22-1230
• 发表时间: 2022-11-01
• 期刊: Diabetes care
• 影响因子: 16.2

Cardiovascular Disease Prevention and Implications of Coronavirus Disease 2019: An Evolving Case Study in the Crescent City.

• DOI: 10.1161/jaha.120.016997
• 发表时间: 2020-07-07
• 期刊: Journal of the American Heart Association
• 影响因子: 5.4
• 作者: Razavi AC;Kelly TN;He J;Fernandez C;Whelton PK;Krousel-Wood M;Bazzano LA
• 通讯作者: Bazzano LA

Health, Neighborhoods, and School Readiness from the Parent Perspective: A Qualitative Study of Contextual and Socio-Emotional Factors.

• DOI: 10.3390/ijerph18179350
• 发表时间: 2021-09-04
• 期刊: International journal of environmental research and public health
• 作者: Dunaway LEF;Bazzano AN;Gray SAO;Theall KP
• 通讯作者: Theall KP

Daily steps and all-cause mortality: a meta-analysis of 15 international cohorts.

• DOI: 10.1016/s2468-2667(21)00302-9
• 发表时间: 2022-03
• 期刊: LANCET PUBLIC HEALTH
• 影响因子: 50
• 作者: Paluch, Amanda E.;Bajpai, Shivangi;Bassett, David R.;Carnethon, Mercedes R.;Ekelund, Ulf;Evenson, Kelly R.;Galuska, Deborah A.;Jefferis, Barbara J.;Kraus, William E.;Lee, I. -Min;Matthews, Charles E.;Omura, John D.;Patel, Alpa, V;Pieper, Carl F.;Rees-Punia, Erika;Dallmeier, Dhayana;Klenk, Jochen;Whincup, Peter H.;Dooley, Erin E.;Gabriel, Kelley Pettee;Palta, Priya;Pompeii, Lisa A.;Chernofsky, Ariel;Larson, Martin G.;Vasan, Ramachandran S.;Spartano, Nicole;Ballin, Marcel;Nordstrom, Peter;Nordstrom, Anna;Anderssen, Sigmund A.;Hansen, Bjorge H.;Cochrane, Jennifer A.;Dwyer, Terence;Wang, Jing;Ferrucci, Luigi;Liu, Fangyu;Schrack, Jennifer;Urbanek, Jacek;Saint-Maurice, Pedro F.;Yamamoto, Naofumi;Yoshitake, Yutaka;Newton Jr, Robert L.;Yang, Shengping;Shiroma, Eric J.;Fulton, Janet E.
• 通讯作者: Fulton, Janet E.