Puerto Rico Biobank

波多黎各生物银行

基本信息

批准号：
10249956
负责人：
IDHALIZ FLORES
金额：
$ 29.96万
依托单位：
PONCE SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-25 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10249956
关键词：
Address Admixture African Amerindian Biocompatible Materials Biological Biological Specimen Banks Blood Cancer Biology Cancer Center Cancer Patient Cancer Prognosis Clinic Clinical Clinical Data Clinics and Hospitals Collaborations Collection Communities Community Outreach Computerized Medical Record Consent Consultations Core Facility DNA Data Databases Diagnosis Documentation Educational Activities Ensure Environment Equipment and supply inventories Ethnic Origin European Event Florida Formalin Fostering Freezing Funding Genes Genetic Genome Genomic DNA Genomics Geographic Locations Goals Grant Health Sciences Hispanics Hospitals Human Image Individual Individual Differences Informatics Infrastructure Institution Island Knowledge Laboratories Latino Life Style Malignant Neoplasms Medical Students Minority Groups Molecular Mutation Names Oncologist Paraffin Paraffin Embedding Pathologic Pathology Patients Plasma Population Population Heterogeneity Precision Medicine Initiative Predisposition Process Puerto Rican Puerto Rico RNA Reporting Research Research Infrastructure Research Personnel Research Project Grants Research Support Resources Risk Factors Sampling Scanning Science Serum Slide Solid Students System Time Tissue Microarray Tissue Procurements Tissues Training Translational Research Tumor Tissue Tumor-Derived Underrepresented Populations Universities Work anticancer research base biobank cancer health disparity clinical risk data harmonization data quality design disorder risk education research electronic data epidemiologic data ethnic minority population gene environment interaction health disparity improved neoplasm registry outreach personalized medicine precision medicine precision oncology quality assurance racial minority recruit repository risk prediction student training translational cancer research treatment response treatment strategy trend tumor

项目摘要

PROJECT SUMMARY/ABSTRACT In order to move closer to achieving the goals of precision medicine and individualized cancer care, participation in biobanking from large numbers of individuals representing all ethnicities is essential. The scarcity of tissues available at existing biobanks from racial and ethnic minorities poses a substantial constraint to conducting research needed to understand the biological basis of health disparities. Because cancer- causing genetic alterations vary across individuals and ethnicities, the practice of precision medicine requires knowledge acquired through the study of tumor tissue derived from individuals representing diverse populations. It is important to recognize that Hispanic/Latino (H/L) ethnicity is an admixture of European, African, and Amerindians ancestral genomes, the proportions of which vary widely across individuals from different geographical regions. Also, there are differences in cancer trends associated to cancer biology and admixture genetics among different H/L sub-populations. Despite being a large proportion of the ethnic minorities living in the US, to date, there has been no comprehensive availability of tumor tissue from H/L cancer patients in national biobanks. To address this disparity, we propose to continue to develop the existing research infrastructure of the Puerto Rico Biobank (PRBB) to support research initiatives designed to understand the biological basis of cancer health disparities. The purpose of the PRBB is to facilitate the optimal collection, processing, storage, and distribution of well-annotated human biospecimens derived from the island’s H/L population for use in investigator-initiated translational cancer research. Throughout the past 10 years, a solid infrastructure has been put in place to develop this unique biorepository in Puerto Rico. Through this resource, fresh frozen tissues, paraffin blocks, high-quality tumor-derived RNA, genomic DNA, and clinical and risk factor information are available to support research at both institutions focusing on molecular aspects and determinants of cancer health disparities involving H/L living in Florida and Puerto Rico. We propose to expand the existing Partnership’s biobank via three Specific Aims. In Aim 1 we propose to continue the collection, processing, storage, and distribution of biospecimens in collaboration with local hospitals and clinics. In cooperation with the Partnership’s Outreach Core, efforts to consent healthy individuals during community outreach educational activities will continue. In Aim 2, we propose to extend the documentation of demographic, clinical, pathological, and molecular data (‘omic’, ancestry, next-gen sequence data) in collaboration with the Quantitative Sciences Core. In Aim 3, we propose to foster new collaborative research projects focused on cancer research. As facilitator of translational research, the PRBB is placed at the forefront of the Precision Medicine initiative programmatic goals of improving disease risk prediction and developing diagnosis and treatment strategies based on individual differences in genes, lifestyle, and environment, focusing on a population that is under-represented in biobanks and research.

项目概要/摘要为了更接近实现精准医疗和个体化癌症护理的目标，代表所有种族的大量个人参与生物样本库至关重要。现有生物库中来自少数种族和族裔的可用组织的稀缺构成了重大限制开展研究需要了解健康差异的生物学基础，因为癌症—— 基因改变因个人和种族而异，精准医学的实践需要通过研究来自代表不同个体的肿瘤组织而获得的知识重要的是要认识到西班牙裔/拉丁裔 (H/L) 种族是欧洲、非洲人和美洲印第安人的祖先基因组，其比例在不同种族之间差异很大此外，与癌症生物学和相关的癌症趋势也存在差异。尽管在种族中占很大比例，但不同 H/L 亚群之间存在混合遗传学。居住在美国的少数族裔，迄今为止，还没有从 H/L 中全面获得肿瘤组织为了解决这一差距，我们建议继续发展现有的生物库。波多黎各生物银行 (PRBB) 的研究基础设施，用于支持旨在了解癌症健康差异的生物学基础 PRBB 的目的是促进最佳治疗。收集、处理、储存和分发来自生物样本的注释良好的人类生物样本岛的 H/L 人群在过去 10 年中用于研究者发起的转化癌症研究。多年来，在波多黎各建立了坚实的基础设施来开发这个独特的生物储存库。该资源、新鲜冷冻组织、石蜡块、高质量肿瘤来源的 RNA、基因组 DNA 和临床和风险因素信息可支持两个机构专注于分子方面的研究以及涉及居住在佛罗里达州和波多黎各的 H/L 的癌症健康差异的决定因素。我们建议通过目标 1 中的三个具体目标来扩大现有合作伙伴关系的生物库。继续与当地合作收集、处理、储存和分发生物样本医院和诊所与合作伙伴的外展核心合作，努力获得健康同意。在目标 2 中，我们建议延长社区外展教育活动期间的个人。人口统计、临床、病理和分子数据（“组学”、祖先、下一代序列）的记录数据）与定量科学核心合作在目标 3 中，我们建议促进新的协作。作为转化研究的推动者，PRBB 被定位为专注于癌症研究的研究项目。精准医学倡议的前沿计划目标是改善疾病风险预测和根据基因、生活方式等个体差异制定诊断和治疗策略环境，重点关注生物库和研究中代表性不足的人群。