Puerto Rico Biobank

波多黎各生物银行

• 批准号: 10249956
• 负责人: IDHALIZ FLORES
• 金额: $ 29.96万
• 依托单位: PONCE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-25 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10249956
• 关键词: Address; Admixture; African; Amerindian; Biocompatible Materials; Biological; Biological Specimen Banks; Blood; Cancer Biology; Cancer Center; Cancer Patient; Cancer Prognosis; Clinic; Clinical; Clinical Data; Clinics and Hospitals; Collaborations; Collection; Communities; Community Outreach; Computerized Medical Record; Consent; Consultations; Core Facility; DNA; Data; Databases; Diagnosis; Documentation; Educational Activities; Ensure; Environment; Equipment and supply inventories; Ethnic Origin; European; Event; Florida; Formalin; Fostering; Freezing; Funding; Genes; Genetic; Genome; Genomic DNA; Genomics; Geographic Locations; Goals; Grant; Health Sciences; Hispanics; Hospitals; Human; Image; Individual; Individual Differences; Informatics; Infrastructure; Institution; Island; Knowledge; Laboratories; Latino; Life Style; Malignant Neoplasms; Medical Students; Minority Groups; Molecular; Mutation; Names; Oncologist; Paraffin; Paraffin Embedding; Pathologic; Pathology; Patients; Plasma; Population; Population Heterogeneity; Precision Medicine Initiative; Predisposition; Process; Puerto Rican; Puerto Rico; RNA; Reporting; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resources; Risk Factors; Sampling; Scanning; Science; Serum; Slide; Solid; Students; System; Time; Tissue Microarray; Tissue Procurements; Tissues; Training; Translational Research; Tumor Tissue; Tumor-Derived; Underrepresented Populations; Universities; Work; anticancer research; base; biobank; cancer health disparity; clinical risk; data harmonization; data quality; design; disorder risk; education research; electronic data; epidemiologic data; ethnic minority population; gene environment interaction; health disparity; improved; neoplasm registry; outreach; personalized medicine; precision medicine; precision oncology; quality assurance; racial minority; recruit; repository; risk prediction; student training; translational cancer research; treatment response; treatment strategy; trend; tumor

PROJECT SUMMARY/ABSTRACT In order to move closer to achieving the goals of precision medicine and individualized cancer care, participation in biobanking from large numbers of individuals representing all ethnicities is essential. The scarcity of tissues available at existing biobanks from racial and ethnic minorities poses a substantial constraint to conducting research needed to understand the biological basis of health disparities. Because cancer- causing genetic alterations vary across individuals and ethnicities, the practice of precision medicine requires knowledge acquired through the study of tumor tissue derived from individuals representing diverse populations. It is important to recognize that Hispanic/Latino (H/L) ethnicity is an admixture of European, African, and Amerindians ancestral genomes, the proportions of which vary widely across individuals from different geographical regions. Also, there are differences in cancer trends associated to cancer biology and admixture genetics among different H/L sub-populations. Despite being a large proportion of the ethnic minorities living in the US, to date, there has been no comprehensive availability of tumor tissue from H/L cancer patients in national biobanks. To address this disparity, we propose to continue to develop the existing research infrastructure of the Puerto Rico Biobank (PRBB) to support research initiatives designed to understand the biological basis of cancer health disparities. The purpose of the PRBB is to facilitate the optimal collection, processing, storage, and distribution of well-annotated human biospecimens derived from the island’s H/L population for use in investigator-initiated translational cancer research. Throughout the past 10 years, a solid infrastructure has been put in place to develop this unique biorepository in Puerto Rico. Through this resource, fresh frozen tissues, paraffin blocks, high-quality tumor-derived RNA, genomic DNA, and clinical and risk factor information are available to support research at both institutions focusing on molecular aspects and determinants of cancer health disparities involving H/L living in Florida and Puerto Rico. We propose to expand the existing Partnership’s biobank via three Specific Aims. In Aim 1 we propose to continue the collection, processing, storage, and distribution of biospecimens in collaboration with local hospitals and clinics. In cooperation with the Partnership’s Outreach Core, efforts to consent healthy individuals during community outreach educational activities will continue. In Aim 2, we propose to extend the documentation of demographic, clinical, pathological, and molecular data (‘omic’, ancestry, next-gen sequence data) in collaboration with the Quantitative Sciences Core. In Aim 3, we propose to foster new collaborative research projects focused on cancer research. As facilitator of translational research, the PRBB is placed at the forefront of the Precision Medicine initiative programmatic goals of improving disease risk prediction and developing diagnosis and treatment strategies based on individual differences in genes, lifestyle, and environment, focusing on a population that is under-represented in biobanks and research.

项目摘要/摘要 为了靠近实现精确医学和个性化癌症护理的目标， 参与来自代表所有种族的大量个人的生物群是必不可少的。这 来自种族和少数民族现有的生物库中可用的组织的稀缺性构成了很大的限制 进行研究以了解健康差异的生物学基础。因为癌症 - 导致遗传改变在个人和种族之间各不相同，精确医学的实践需要 通过研究从代表潜水员的个体得出的肿瘤组织获得的知识 人群。重要的是要认识到西班牙裔/拉丁裔（H/L）种族是欧洲的混合物， 非洲和美国的祖先基因组，其比例在 不同的地理区域。此外，与癌症生物学相关的癌症趋势和 不同的H/L亚群中的混合遗传学。尽管是种族的很大比例 迄今为止，居住在美国的少数民族尚无H/L的肿瘤组织的全面供应 国家生物库中的癌症患者。为了解决这一差异，我们建议继续开发现有的 波多黎各生物库（PRBB）的研究基础设施支持旨在的研究计划 了解癌症健康差异的生物学基础。 PRBB的目的是促进最佳 源自源自的人类生物素的收集，加工，存储和分布。 岛的H/L人群用于研究人员引发的转化癌症研究。在过去的十个 多年来，已经建立了一个可靠的基础设施，以开发波多黎各的这种独特的生物库。通过 这种资源，新鲜的冷冻组织，石蜡块，高质量的肿瘤衍生RNA，基因组DNA和临床 和风险因素信息可用于支持两个机构的研究，侧重于分子方面 并确定涉及居住在佛罗里达州和波多黎各的H/L的癌症健康差异。 我们建议通过三个特定目标扩大现有合作伙伴的生物库。在目标1中，我们提出了 继续与本地合作的生物测量的收集，处理，存储和分发 医院和诊所。与合作伙伴关系的外展核心合作，努力同意健康 在AIM 2中，我们建议扩展 人口统计学，临床，病理和分子数据的文档（“ Omic”，Ancestry，下一代序列 数据）与定量科学核心合作。在AIM 3中，我们建议促进新的合作 研究项目的重点是癌症研究。作为翻译研究的促进者，PRBB被置于 Precision Medicine Initiative的最前沿的计划目标是改善疾病风险预测和 基于基因，生活方式和 环境，专注于生物库和研究中代表性不足的人群。