SPECT Imaging of Peripheral Vascular Disease

周围血管疾病的 SPECT 成像

基本信息

批准号：
10248379
负责人：
Chi Liu
金额：
$ 109.94万
依托单位：
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-01 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10248379
关键词：
3-Dimensional Acidosis Affect American Angiography Area Atherosclerosis Cessation of life Clinical Clinical Research Collimator Complex Computer software Coronary Arteriosclerosis DCNU Deep Vein Thrombosis Disease Electronics Evaluation Gamma Rays Generations Geometry Health Hindlimb Hypoxia Image Imaging Techniques Individual Intermittent Claudication Ischemia Isotopes Lead Life Limb Salvage Limb structure Lower Extremity Medical Metabolic Metabolism Modeling Molecular Molecular Abnormality Muscle Patients Performance Perfusion Peripheral Vascular Diseases Physiological Population Positron-Emission Tomography Prevalence Research Project Grants Resolution Skeletal Muscle System Techniques Technology Therapeutic Intervention Time Tracer Ultrasonography X-Ray Computed Tomography angiogenesis base chronic ulcer claudication clinical imaging compound eye computerized data processing critical limb Ischemia data acquisition design detection platform detector diabetic patient disease diagnosis image reconstruction imaging study lifestyle intervention limb amputation limb ischemia mortality non-invasive imaging porcine model preclinical evaluation preclinical imaging reduce symptoms response restenosis restoration single photon emission computed tomography tissue oxygenation treatment optimization wound healing

项目摘要

In this proposed project, we will develop a so-called Dynamic Extremity SPECT (DE-SPECT) system that utilizes the 3-D HEXIETC CZT detector technology and a synthetic compound-eye camera design for dynamic and multi-tracer SPECT imaging of PVD in lower extremities. Peripheral Vascular Disease (PVD) affects approximately 8 million Americans and an estimated 10% of the worldwide population, with increasing prevalence in older individuals. PVD has significant health implications, resulting in progressive limb ischemia that can lead to life-altering claudication, non-healing ulcers, limb amputation, and, in severe cases, death. Despite these numbers and a close association with coronary artery disease, PVD remains a relatively under-diagnosed disease. Diabetic patients often require revascularization along with medical and life style interventions to achieve symptom relief, wound healing and limb salvage and have higher rates of restenosis, and higher mortality rates following revascularization when compared to non- DM patients. Although treating large vessel disease and restoration of skeletal muscle perfusion is important for critical limb ischemia and a critical contributor to intermittent claudication, there are other important metabolic and molecular abnormalities involved that need to be evaluated in conjunction with changes in muscle perfusion in order to optimize therapy. Revascularization of obstructed vessels often results in an incomplete or heterogeneous restoration of flow and does not fully restore the functional limitations in PAD patients with intermittent claudication. The proposed DE-SPECT system could provide a unique non-invasive approach for the comprehensive assessment of molecular and physiological changes of the lower extremities in patients with peripheral vascular disease (PVD) in response to therapeutic interventions and assessing these changes will be critical for optimizing and following PVD therapy.

在这个拟议的项目中，我们将开发一种所谓的动态肢体 SPECT (DE-SPECT) 系统利用 3-D HEXIETC CZT 探测器技术和合成复眼相机设计，实现动态以及下肢 PVD 的多示踪剂 SPECT 成像。周围血管疾病 (PVD) 影响着大约 800 万美国人，估计占美国人口的 10% 全世界人口中，老年人中患病率不断增加。 PVD 对健康具有重大影响，导致进行性肢体缺血，从而导致改变生活的跛行、不愈合的溃疡、肢体截肢，严重时甚至死亡。尽管有这些数字并且与冠状动脉密切相关疾病，PVD 仍然是一种相对诊断不足的疾病。糖尿病患者通常需要血运重建结合医疗和生活方式干预措施，以实现症状缓解、伤口愈合和保肢，与非治疗相比，血运重建后再狭窄率更高，死亡率更高糖尿病患者。尽管治疗大血管疾病和恢复骨骼肌灌注对于严重的肢体缺血和间歇性跛行的关键因素，还有其他重要的代谢因素以及涉及的分子异常需要结合肌肉灌注的变化进行评估以优化治疗。阻塞血管的血运重建通常会导致不完全或血流的异质恢复并不能完全恢复 PAD 患者的功能限制间歇性跛行。所提出的 DE-SPECT 系统可以为综合性检测提供一种独特的非侵入性方法。周围血管病患者下肢分子和生理变化的评估疾病（PVD）响应治疗干预并评估这些变化对于优化至关重要以及 PVD 治疗后。