SPECT Imaging of Peripheral Vascular Disease

周围血管疾病的 SPECT 成像

• 批准号: 10248379
• 负责人: Chi Liu
• 金额: $ 109.94万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10248379
• 关键词: 3-Dimensional; Acidosis; Affect; American; Angiography; Area; Atherosclerosis; Cessation of life; Clinical; Clinical Research; Collimator; Complex; Computer software; Coronary Arteriosclerosis; DCNU; Deep Vein Thrombosis; Disease; Electronics; Evaluation; Gamma Rays; Generations; Geometry; Health; Hindlimb; Hypoxia; Image; Imaging Techniques; Individual; Intermittent Claudication; Ischemia; Isotopes; Lead; Life; Limb Salvage; Limb structure; Lower Extremity; Medical; Metabolic; Metabolism; Modeling; Molecular; Molecular Abnormality; Muscle; Patients; Performance; Perfusion; Peripheral Vascular Diseases; Physiological; Population; Positron-Emission Tomography; Prevalence; Research Project Grants; Resolution; Skeletal Muscle; System; Techniques; Technology; Therapeutic Intervention; Time; Tracer; Ultrasonography; X-Ray Computed Tomography; angiogenesis; base; chronic ulcer; claudication; clinical imaging; compound eye; computerized data processing; critical limb Ischemia; data acquisition; design; detection platform; detector; diabetic patient; disease diagnosis; image reconstruction; imaging study; lifestyle intervention; limb amputation; limb ischemia; mortality; non-invasive imaging; porcine model; preclinical evaluation; preclinical imaging; reduce symptoms; response; restenosis; restoration; single photon emission computed tomography; tissue oxygenation; treatment optimization; wound healing

In this proposed project, we will develop a so-called Dynamic Extremity SPECT (DE-SPECT) system that utilizes the 3-D HEXIETC CZT detector technology and a synthetic compound-eye camera design for dynamic and multi-tracer SPECT imaging of PVD in lower extremities. Peripheral Vascular Disease (PVD) affects approximately 8 million Americans and an estimated 10% of the worldwide population, with increasing prevalence in older individuals. PVD has significant health implications, resulting in progressive limb ischemia that can lead to life-altering claudication, non-healing ulcers, limb amputation, and, in severe cases, death. Despite these numbers and a close association with coronary artery disease, PVD remains a relatively under-diagnosed disease. Diabetic patients often require revascularization along with medical and life style interventions to achieve symptom relief, wound healing and limb salvage and have higher rates of restenosis, and higher mortality rates following revascularization when compared to non- DM patients. Although treating large vessel disease and restoration of skeletal muscle perfusion is important for critical limb ischemia and a critical contributor to intermittent claudication, there are other important metabolic and molecular abnormalities involved that need to be evaluated in conjunction with changes in muscle perfusion in order to optimize therapy. Revascularization of obstructed vessels often results in an incomplete or heterogeneous restoration of flow and does not fully restore the functional limitations in PAD patients with intermittent claudication. The proposed DE-SPECT system could provide a unique non-invasive approach for the comprehensive assessment of molecular and physiological changes of the lower extremities in patients with peripheral vascular disease (PVD) in response to therapeutic interventions and assessing these changes will be critical for optimizing and following PVD therapy.

在这个拟议的项目中，我们将开发一个所谓的动态肢体SPECT（DE-SEPP）系统，该系统 利用3-D HEXIETC CZT检测器技术和用于动态的合成化合物摄像头设计 和下肢PVD的多跟踪SPECT成像。 周围血管疾病（PVD）影响约800万美国人，估计有10％ 全球人口，老年人的患病率越来越高。 PVD具有重大的健康影响， 导致促进性肢体缺血，可能导致改变生活的lau不休，非愈合溃疡，肢体 截肢，在严重的情况下死亡。尽管有这些数字，并且与冠状动脉密切相关 疾病，PVD仍然是一种相对诊断的疾病。糖尿病患者通常需要血运重建 以及医疗和生活方式干预措施以减轻症状，伤口愈合和肢体救助以及 与非 - DM患者。尽管治疗大血管疾病和骨骼肌灌注的恢复对 关键的肢体缺血和间歇性lau不平的关键因素，还有其他重要的代谢 以及涉及的分子异常，需要与肌肉灌注的变化一起评估 为了优化治疗。阻塞血管的血运重建通常导致不完整或 流动的异质恢复，并未完全恢复PAD患者的功能限制 间歇性lau不平。 拟议的DEPEPS系统可以为全面提供独特的非侵入性方法 评估外周血管患者下肢的分子和生理变化 疾病（PVD）响应治疗干预措施并评估这些变化对于优化至关重要 并进行PVD疗法。