Project 3: The abuse liability and substitution profile of removing cigarette ventilation in the experimental tobacco marketplace

项目 3：实验烟草市场中去除卷烟通风的滥用倾向和替代概况

• 批准号: 10246920
• 负责人: Warren K Bickel
• 金额: $ 36.11万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-20 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10246920
• 关键词: Address; Adult; Affect; Alternative Nicotine Delivery Systems; Animals; Biological Markers; Cigarette; Complement; Complex; Consumption; Data; Economics; Elasticity; Electronic cigarette; Environment; Exposure to; Gender; Goals; Grant; Health; Light; Long-Term Effects; Lung Adenocarcinoma; Mainstreaming; Measures; Methods; Modeling; Nicotine; Palate; Participant; Policies; Price; Public Health; Regulation; Research; Risk; Series; Smoke; Smokeless Tobacco; Smoker; Smoking; Taste Perception; Testing; Tobacco; Tobacco Industry; Tobacco use; Toxic effect; United States; United States Food and Drug Administration; authority; behavioral economics; cigarette smoke; deprivation; design; evidence base; experience; non-cigarette tobacco product; preference; prospective; tobacco products; ventilation

ABSTRACT Cigarette filter ventilation is a major design feature of the majority of cigarettes sold in the United States and abroad. Although filter ventilation was initially intended to produce a lighter tasting and potentially safer cigarette by diluting mainstream cigarette smoke, data have since suggested that ventilation instead increases total harm from smoking by inducing compensatory smoking (e.g., increased puff volume and/or more cigarettes smoked per day due to reduced nicotine yields) and may increase cigarette abuse liability (addictive potential). The goal of this project is to use the recently developed Experimental Tobacco Marketplace to assess the effects of removing filter ventilation, thereby modeling a regulatory environment in which filter ventilation was banned, on behavioral economic measures of abuse liability. In a series of studies featuring both between- and within-subject design components, the research team will compare purchasing and consumption of unventilated and ventilated cigarettes across a broad range of prices, as well as examine how filter ventilation impacts the degree to which an array of alternative nicotine delivery systems (e.g., electronic cigarettes, smokeless tobacco) serve as economic substitutes for cigarettes. Moreover, we will model electronic cigarette regulatory restrictions on flavor and available nicotine concentrations to examine how such restrictions interact with cigarette filter ventilation to affect tobacco consumption. Together, the findings from this project could be used to inform and maximize the efficacy of regulatory action regarding cigarette filter ventilation and alternative nicotine delivery systems.

抽象的 香烟过滤通风是美国出售的大多数香烟的主要设计特征 和国外。尽管过滤通风最初是为了产生较轻的品尝，并有可能 通过稀释主流香烟烟来更安全的香烟，数据提出了通风 相反，通过诱导补偿性吸烟增加吸烟会增加造成的总危害（例如，粉扑增加 由于尼古丁产量的降低，每天吸烟的体积和/或更多的香烟）可能会增加 香烟滥用责任（上瘾的潜力）。该项目的目的是使用最近开发的 实验性烟草市场，以评估去除过滤器通气的影响，从而建模 禁止过滤通风的监管环境，以行为经济措施 虐待责任。在一系列具有受试者内部和受试者内部设计组件的研究中， 研究团队将比较未通风和通风香烟的购买和消费 在广泛的价格上，并研究过滤通风如何影响 替代尼古丁输送系统（例如电子烟，无烟烟草）作为 经济替代香烟。此外，我们将建模电子烟调节限制 在风味和可用的尼古丁浓度上，以检查这种限制如何与香烟相互作用 过滤通风以影响烟草消费。一起，这个项目的发现可以用来 告知和最大化有关香烟过滤通风和替代方案的监管行动的功效 尼古丁输送系统。