Testing Reinforcer Pathology: Mechanisms and Interventions to Change Alcohol Valuation

测试强化物病理学：改变酒精估值的机制和干预措施

基本信息

批准号：
10679071
负责人：
Warren K Bickel
金额：
$ 65.59万
依托单位：
VIRGINIA POLYTECHNIC INST AND ST UNIV
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-01 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10679071
关键词：
Address Age Alcohol consumption Alcohols Amygdaloid structure Anterior Behavioral Biological Models Brain region Clinical Computer Models Data Economics Environment Evidence based treatment Functional Magnetic Resonance Imaging Future Generations Goals Hippocampus Individual Individual Differences Intervention Laboratories Laboratory Sensitivity Lateral Learning Length Link Literature Measures Medicine Methods Modeling Nature Neurobiology Neurocognitive Outcome Outpatients Participant Pathology Pharmaceutical Preparations Pharmacological Treatment Prefrontal Cortex Process Psychological reinforcement Public Health Research Research Project Grants Self Administration Specific qualifier value Testing Thinking Time Translational Research Ventral Striatum Work addiction alcohol abuse therapy alcohol demand alcohol intervention alcohol related problem alcohol use disorder behavioral economics biobehavior cognitive control comparison control computational neuroscience craving discounting efficacious intervention experimental study field study improved innovation insight interest intervention effect mathematical model neural neurofeedback neuroimaging novel open innovation psychosocial reinforcer remote monitoring sex simulation theories therapeutic target

项目摘要

PROJECT SUMMARY Developing a new generation of interventions for alcohol use disorder (AUD) constitutes an important scientific gap and, if addressed, will open innovation opportunities. To address this gap, we propose to examine an emerging novel framework for addiction, reinforcer pathology. Reinforcer pathology specifies that reinforcers are integrated over a temporal window, and the length of that window determines the relative value of different reinforcers. When the temporal window is short, reinforcers such as alcohol, which are brief, intense, and reliable, will have greater value. Conversely, as the temporal window lengthens, other more temporally extended reinforcers begin to have greater influence and alcohol valuation will decrease. The concept of reinforcer pathology identifies the temporal window, measured with delay discounting (i.e., the decline in the value of a reinforcer as a function of its delay), as a therapeutic target for AUD, and it permits target engagement via innovative interventions (e.g., episodic future thinking; EFT) to provide novel insights into alcohol valuation. This project uses multiple analytical levels (e.g., the behavioral laboratory, an outpatient field study, neuroimaging, and computational modeling) to quantify, predict, and modulate alcohol valuation among individuals with AUD. In Aim 1, we will examine manipulations that increase and decrease the temporal window to mechanistically test the reinforcer pathology framework. In Aim 1a, we will examine the effects of an intervention that increases the temporal window (EFT) on concomitant changes in alcohol valuation (self-administration, craving, and behavioral economic alcohol demand). In addition, participants in Aim 1a will participate in a proof-of-concept field study, where remote implementation of EFT will be used to impact alcohol drinking (measured by remote monitoring of breath alcohol) in the natural environment. In Aim1b, we will examine the effects of a manipulation that decreases the temporal window (simulation of economic scarcity) on concomitant changes in alcohol valuation. Throughout Aim 1, neural activity associated with changes in the temporal window will also be examined. In Aim 2, we will use multi-voxel analyses of fMRI data to explore two independent sub-aims related to reinforcer pathology in AUD. First, in Aim 2a, we will build multivariate group regression models of fMRI delay discounting data in a subset of participants with AUD to predict discounting in an independent subset of participants. Second, in Aim 2b, we will use real-time fMRI neurofeedback to enhance participants' ability to control their temporal window, and hence their ability to modulate delay discounting and alcohol valuation. In Aim 3, we will model the temporal window to extend the existing literature by computationally quantifying results from Aims 1 and 2 (Aim 3a), and connecting subjective value to brain regions of interest using computational neuroscience (Aim 3b). Together, the findings from this rigorous and innovative research project will improve our understanding of AUD and highlight potential novel and efficacious intervention strategies.

项目摘要开发新一代的酒精使用障碍干预措施（AUD）构成了重要的科学差距，如果解决的话，将开放创新机会。为了解决这一差距，我们建议检查一个新兴的成瘾，增强病理学的新颖框架。增强剂病理学指出了增强剂是集成在时间窗口上，该窗口的长度决定了不同的相对值增强剂。当时间窗口短时，诸如酒精之类的加固剂是简短，强烈且可靠的，将具有更大的价值。相反，随着时间窗口的延长，其他更暂时的扩展增强剂开始具有更大的影响力，酒精估值将减少。增强器的概念病理识别时间窗口，以延迟折现测量（即增强器随延迟的函数），作为AUD的治疗目标，并允许通过创新的干预措施（例如，情节的未来思维； eft）为酒精估值提供新颖的见解。这项目使用多个分析水平（例如，行为实验室，门诊现场研究，神经影像学，和计算建模），以量化，预测和调节AUD个体之间的酒精评估。在AIM 1中，我们将检查增加和减少时间窗口的操作以进行机械测试增强病理框架。在AIM 1A中，我们将研究一种干预措施的影响，以增加时间窗口（EFT）关于酒精估值的随之变化（自我管理，渴望和行为经济酒精需求）。此外，AIM 1A的参与者将参加概念验证现场研究，远程实施EFT将用于影响饮酒（通过远程监控来衡量呼吸酒精）在自然环境中。在AIM1B中，我们将检查降低的操作的效果临时窗口（模拟经济稀缺）关于酒精评估的随之变化。自始至终 AIM 1，还将检查与时间窗口变化相关的神经活动。在AIM 2中，我们将使用fMRI数据的多素分析来探索与增强病理学有关的两个独立子iap 奥德首先，在AIM 2A中，我们将构建fMRI的多元组回归模型延迟折现数据具有AUD参与者的子集，以预测参与者独立子集中的折扣。第二，目标 2B，我们将使用实时fMRI Neurofeffack来增强参与者控制其时间窗口的能力，因此，它们能够调节延迟打折和酒精估值的能力。在AIM 3中，我们将建模时间通过AIMS 1和2（AIM 3A）和使用计算神经科学（AIM 3B）将主观价值与感兴趣的大脑区域联系起来。一起，这个严格而创新的研究项目的发现将提高我们对AUD和强调潜在的新颖和有效的干预策略。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

The phenotype of recovery II: The association between delay discounting, self-reported quality of life, and remission status among individuals in recovery from substance use disorders.

DOI：
10.1037/pha0000389
发表时间：
2022-02
期刊：
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
影响因子：
2.3
作者：
Athamneh, Liqa N.;Lemos, Roberta Freitas;Basso, Julia C.;Tomlinson, Devin C.;Craft, William H.;Stein, Madison D.;Bickel, Warren K.
通讯作者：
Bickel, Warren K.

Are poor quality data just random responses?: A crowdsourced study of delay discounting in alcohol use disorder.

DOI：
10.1037/pha0000549
发表时间：
2022-08
期刊：
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
影响因子：
2.3
作者：
Craft, William H.;Tegge, Allison N.;Freitas-Lemos, Roberta;Tomlinson, Devin C.;Bickel, Warren K.
通讯作者：
Bickel, Warren K.

Rate-dependent effects of narrative interventions in a longitudinal study of individuals who use alcohol.

DOI：
10.1111/acer.15020
发表时间：
2023-02
期刊：
Alcoholism, clinical and experimental research
影响因子：
0
作者：
W. H. Craft;Candice L. Dwyer;D. Tomlinson;Yu-Hua Yeh;A. Tegge;Warren K. Bickel
通讯作者：
W. H. Craft;Candice L. Dwyer;D. Tomlinson;Yu-Hua Yeh;A. Tegge;Warren K. Bickel

Reinforcer pathology in cocaine use disorder: Temporal window determines cocaine valuation.