Longitudinal Study of Recovery: Psychosocial Functioning, Relapse, and Neuro-Behavioral Markers

康复的纵向研究：心理社会功能、复发和神经行为标志物

• 批准号: 10367669
• 负责人: Warren K Bickel
• 金额: $ 72.52万
• 依托单位: VIRGINIA POLYTECHNIC INST AND ST UNIV
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10367669
• 关键词: Address; Alcohol consumption; Computer Models; Data Collection; Disease remission; Emotional; Environment; Event; Exhibits; Future; Geography; Goals; Health; Impulsivity; Individual; Individual Differences; International; Length; Life Style; Longitudinal Studies; Measurement; Measures; Mediating; Mental Health; Methods; Modeling; National Institute on Alcohol Abuse and Alcoholism; Nature; Neurosciences; Participant; Pathway interactions; Patient Recruitments; Phenotype; Principal Investigator; Privacy; Process; Quality of life; Recording of previous events; Recovery; Registries; Regulation; Relapse; Research; Research Project Grants; Resistance; Sampling; Social support; Specific qualifier value; Subgroup; Symptoms; System; Testing; Time; Variant; addiction; alcohol abuse therapy; alcohol use disorder; discounting; disorder later incidence prevention; editorial; improved; indexing; innovation; longitudinal design; neurobehavioral; novel; online resource; perceived stress; physical conditioning; prevent; preventive intervention; prospective; psychosocial; recruit; reinforcer; repaired; resilience; sex; social; social relationships; socioeconomics; theories

PROJECT SUMMARY Alcohol use disorder (AUD) research typically analyzes relapse and recovery processes over short time-frames, such as during and immediately following a treatment episode. The long-term trajectories of recovery, the impact of relapse episodes, and their associated neurobehavioral markers and precipitants comprise a vital gap in our scientific understanding of the recovery process. Our goals are to provide a scientific understanding of recovery and relapse, as well as to identify novel targets for future relapse prevention interventions. Specifically, changes in the mechanisms underlying AUD will be investigated using the Competing Neurobehavioral Decision Systems (CNDS) framework, which posits that addiction and relapse arise from a regulatory imbalance between the impulsive and executive decision systems. To pursue this goal, participants with AUD will be recruited from the International Quit & Recovery Registry (IQRR), which was established in 2011 and currently has about 8,775 registrants. The IQRR provides a unique online resource that permits the scientific study of recovery processes and the highly efficient collection of data suitable for long-term repeated measurement research. We will use an accelerated longitudinal design, which allows the prospective characterization of psychosocial functioning, relapse, and CNDS functioning across 12 years of AUD recovery by recruiting participants with a range of different recovery lengths, up to 10 years. Over three years, participants will complete quarterly assessments, including measures of CNDS functioning. In Aim 1, we will examine the psychosocial functioning over long-term AUD recovery and how it is impacted by CNDS regulation. In Aim 2, we will examine relapse over long-term AUD recovery and how it is impacted by CNDS regulation. In Aim 3 we will examine the dynamic interaction of CNDS processes impacting the recovery using computational modeling. Together, the findings from this rigorous and innovative research project will improve our understanding of the temporal dynamics and underlying mechanisms of recovery from AUD.

项目摘要 酒精使用障碍（AUD）研究通常会分析简短的复发和恢复过程 时间框架，例如在治疗事件之后和之后立即进行。长期的轨迹 恢复，复发发作的影响及其相关的神经行为标记和降水剂 在我们对恢复过程的科学理解中构成了一个重要差距。我们的目标是提供 对恢复和复发的科学理解，并确定未来复发的新目标 预防干预措施。具体而言，将使用AUD基础机制的变化进行调查 竞争性的神经行为决策系统（CNDS）框架，该框架提出了成瘾和复发 是由冲动和执行决策系统之间的监管失衡引起的。追求这个目标， AUD的参与者将从国际退出与恢复注册表（IQRR）中招募，这是 成立于2011年，目前有约8,775名注册人。 IQRR提供了独特的在线资源 这允许对恢复过程的科学研究以及适合于 长期重复测量研究。我们将使用加速的纵向设计，该设计允许 在12年的时间内的社会心理功能，复发和CND的前瞻性表征 通过招募具有一系列不同恢复长度的参与者，最多10年来恢复。超过三个 年份，参与者将完成季度评估，包括CND功能的度量。在AIM 1中，我们 将检查长期AUD恢复的社会心理功能以及如何受到CND的影响 规定。在AIM 2中，我们将检查长期AUD恢复的复发以及CND的影响如何 规定。在AIM 3中，我们将检查使用使用的CND流程的动态相互作用 计算建模。这项严格而创新的研究项目的发现将共同改善 我们对AUD恢复的时间动态和基本机制的理解。