Behavior Automation

行为自动化

• 批准号: 10247578
• 负责人: Carlos D Brody
• 金额: $ 14.04万
• 依托单位: PRINCETON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-28 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10247578
• 关键词: Animals; Area; Automation; Behavior; Behavioral Research; Brain; Communities; Computer Models; Computer software; Consumption; Decision Making; Documentation; Ensure; Failure; Head; Health; Home; Hour; Human Resources; Individual; Infrastructure; Instruction; Intervention; Japan; Laboratories; Letters; Manuals; Mind; Monitor; Mus; Neurosciences; Practice Management; Procedures; Process; Protocols documentation; Quality Control; Rattus; Reproducibility; Research; Research Personnel; Research Project Grants; Rodent; Running; Sensory; Short-Term Memory; Software Tools; Standardization; System; Time; Training; base; cognitive ability; cognitive task; cost effective; data acquisition; design; experience; experimental study; image registration; improved; neural circuit; neuromechanism; open source; operation; prevent; scale up; software development; support tools; tool; virtual; virtual reality; virtual reality system

Project Summary: Core 3, Behavior Automation Working memory, the ability to temporarily hold multiple pieces of information in mind for manipulation, is central to virtually all cognitive abilities. This multi-component research project aims to comprehensively dissect the neural circuit mechanisms of this ability across multiple brain areas. The individual parts of the project cohere conceptually, in part, because they all involve rodents trained to perform a type of decision-making task that is based on the gradual accumulation of sensory evidence and thus relies on working memory. To produce enough subjects for these experiments, this Core will scale up an existing high-throughput rat training facility run by technicians and adapt it for mice. This expansion will quintuple the project’s capacity for rodent training. To do so, we will take advantage of the expertise of the project leader in developing and managing such a training facility for sophisticated cognitive tasks in an existing virtual reality infrastructure, software, and hardware. Once this facility is operational, the Core will manage it and troubleshoot problems as needed. It will develop new hardware and software components for training rigs to make technician interventions as reproducible and error-free as possible. Because the most crucial and time-consuming aspect of mouse virtual training is ensuring that the head-fixed animal is properly aligned to the ball and the projection system, the Core will develop an automated alignment system based on image registration and actuators to replace the current manual alignment. It will develop software tools and standardized technician procedures to ensure consistency in rodent training, prevent training errors, detect hardware failures, and monitor the health of the animals. This centralized facility will promote rigor and reproducibility by reducing variability in animal training across labs, increase the rate of data acquisition, and free personnel to focus on designing and carrying out creative experiments. In the long run, the entire neuroscience community will benefit from this effort, as the software and hardware tools and management protocols produced will be made freely available, along with their documentation. These tools will enable other researchers to introduce automated training for well-controlled cognitive tasks in their own laboratories, leading to improved efficiency, rigor, and reproducibility in behavioral research across the field of neuroscience.

项目摘要：核心3，行为自动化 工作记忆，暂时保存多个信息的能力 操纵，几乎是所有认知能力的核心。这个多组分研究项目 旨在全面剖析多个能力的神经回路机制 大脑区域。该项目的各个部分在概念上部分是因为它们都 涉及训练训练以执行基于等级的决策任务的啮齿动物 感觉证据的积累，因此依赖于工作记忆。产生足够的 这些实验的受试者，此核心将扩大现有的高通量老鼠训练 设施由技术人员运营，并适合老鼠。这种扩展将使项目的五次 啮齿动物训练的能力。为此，我们将利用该项目的专业知识 在开发和管理这样的培训设施的领导者 现有的虚拟现实基础架构，软件和硬件。一旦此设施运作， 核心将管理它并根据需要解决问题。它将开发新的硬件 以及用于培训钻机的软件组件，以使技术人员干预措施可再现和 尽可能无错误。因为鼠标虚拟的最关键和最耗时的方面 训练正在确保将头部固定的动物适当地与球和投影 系统，核心将根据图像注册和 执行器以取代当前的手动对齐。它将开发软件工具， 标准化技术程序，以确保啮齿动物训练的一致性，防止训练 错误，检测硬件故障并监测动物的健康。这个集中设施 将通过降低实验室的动物训练的变异性来促进严格和可重复性， 提高数据获取的速度，并提高自由工作人员，专注于设计和执行 创意实验。从长远来看，整个神经科学社区将受益于此 努力，将制作软件和硬件工具和管理协议 免费提供，以及他们的文档。这些工具将使其他研究人员能够 在自己的实验室中引入自动化培训，以实现控制良好的认知任务 在整个领域的行为研究中提高了效率，严格和可重复性 神经科学。