EXERCISE, NUTRITION, AND SARCOPENIA IN OLDER ADULTS

老年人的运动、营养和肌肉减少症

• 批准号: 7719193
• 负责人: Hans Christian Dreyer
• 金额: $ 4.77万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719193
• 关键词: Aerobic; Age; Age-Years; Aging; Amino Acids; Carbohydrates; Computer Retrieval of Information on Scientific Projects Database; Eating; Elderly; Exercise; Female; Food; Funding; Grant; Hour; Individual; Ingestion; Institution; Measures; Muscle; Muscle Proteins; Protein Biosynthesis; Proteins; Rate; Research; Research Personnel; Resistance; Resources; Rest; Signal Pathway; Solutions; Source; Training; Training Programs; United States National Institutes of Health; Water; Week; base; mTOR Signaling Pathway; male; nutrition; response; sarcopenia; sugar

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Nutrition and resistance exercise training can be useful in maintaining and increasing muscle mass in the elderly. However, some studies suggest that when carbohydrates are ingested with protein, muscle protein synthesis may be blunted in older individuals whereas when the amino acids are ingested alone, synthesis is normal. The specific aims are: 1) To determine which signaling pathways are responsible for the blunted response of muscle protein synthesis associated with mixed meal (protein and sugar) ingestion in aging. 2) To determine if a 12-week water-based exercise training program (utilizing both aerobic and resistance exercises) will restore the response of mixed meal (protein and sugar) ingestion in older subjects. In young healthy males and females between the ages of 18-40 years and older healthy males and females 60-85 years of age we will measure the response of ingestion protein and sugar. The older subjects will then perform 12 weeks of water based exercise 3 x/week for one hour. We will then measure the older subjects' response to ingesting protein and sugar after the 12 weeks of water exercise. We will measure the signaling pathways (mTOR) and fractional synthetic rate of muscle protein synthesis in all subjects at rest and after ingesting the protein and sugar solution. In the older subjects we will also measure the type and amount of food they eat throughout the study period.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 营养和抵抗运动训练可用于维持老年人的肌肉质量和增加肌肉。 但是，一些研究表明，当碳水化合物被蛋白质摄入时，肌肉蛋白质的合成可能会在老年人中钝化，而当单独摄入氨基酸时，合成是正常的。 具体目的是： 1）确定哪些信号通路负责与衰老中混合粉（蛋白质和糖）摄入相关的肌肉蛋白质合成的钝化反应。 2）确定一个为期12周的水基锻炼训练计划（使用有氧运动和耐药性练习）是否会恢复老年受试者中混合餐（蛋白质和糖）的反应。 在18-40岁及以上的年龄较大的男性和女性的年轻男性和女性中，60-85岁的女性将测量摄入蛋白和糖的反应。然后，较旧的受试者将进行12周的水基锻炼3 x/周，持续一小时。然后，我们将测量较老的受试者对摄入蛋白质和糖的反应，在水上运动12周后。 我们将测量所有受试者在休息和摄入蛋白质和糖溶液后所有受试者中肌肉蛋白合成的信号传导途径（MTOR）和分数合成速率。在较旧的学科中，我们还将在整个研究期间衡量他们吃的食物的类型和数量。