SKELETAL MUSCLE METABOLISM AND TOTAL KNEE ARTHROPLASTY (TKA)

骨骼肌代谢和全膝关节置换术 (TKA)

基本信息

批准号：
7952162
负责人：
Hans Christian Dreyer
金额：
$ 0.21万
依托单位：
UNIVERSITY OF TEXAS MED BR GALVESTON
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-04-01 至 2009-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7952162
关键词：
Affect Amino Acids Beds Biopsy Clinical Research Computer Retrieval of Information on Scientific Projects Database Elderly Essential Amino Acids Funding Goals Grant Growth Institution Isotopes Light Measures Methods Muscle Muscle Proteins Nutrient Operative Surgical Procedures Pain Physical therapy Placebos Regulation Research Research Personnel Resources Signal Transduction Skeletal Muscle Solutions Source Thigh structure United States National Institutes of Health knee replacement arthroplasty muscle metabolism

Affect Amino Acids Beds Biopsy Clinical Research Computer Retrieval of Information on Scientific Projects Database Elderly Essential Amino Acids Funding Goals Grant Growth Institution Isotopes Light Measures Methods Muscle Muscle Proteins Nutrient Operative Surgical Procedures Pain Physical therapy Placebos Regulation Research Research Personnel Resources Signal Transduction Skeletal Muscle Solutions Source Thigh structure United States National Institutes of Health knee replacement arthroplasty muscle metabolism

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项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this research is to help us to determine the underlying mechanisms involved in the regulation of skeletal muscle loss and regrowth in older adults after complete knee replacement surgery (also known as total knee arthroplasty or TKA). We will determine if the ability of muscle growth is influenced by physical therapy followed by ingesting a nutrient solution containing muscle protein building blocks (essential amino acids). We will determine if the ability of muscle growth is influenced by physical therapy. To measure the potential negative affects of total knee replacement surgery we will use stable amino acid isotopes to the subjects before and after their surgery. We will take muscle biopsies of the thigh muscle to determine the rate at which each subject is producing muscle protein and measure the changes in signals produced by muscle are responsible for muscle growth. To measure the affects of physical therapy with or without a growth promoting nutrient solution of essential amino acids we will study each subject 4 days after their surgery (they will have less pain and more mobility on day 4) before (while lying in bed) and after a session of physical therapy + placebo or physical therapy + growth promoting nutrient solution. These studies will first give us an understanding of the effects of total knee replacement surgery on muscle metabolism and shed light on traditional methods used to regain strength following this surgery (i.e., physical therapy).

该副本是利用众多研究子项目之一由NIH/NCRR资助的中心赠款提供的资源。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构是对于中心，这不一定是调查员的机构。这项研究的目的是帮助我们确定完成膝关节置换手术后老年人骨骼肌损失和再生的潜在机制（也称为总膝关节置换术或TKA）。我们将确定肌肉生长的能力是否受物理疗法的影响，然后摄入含有肌肉蛋白质组成块（必需氨基酸）的营养溶液。我们将确定肌肉生长的能力是否受物理治疗的影响。为了衡量总膝盖置换手术的潜在负面影响，我们将在手术前后对受试者使用稳定的氨基酸同位素。我们将服用大腿肌肉的肌肉活检，以确定每个受试者产生肌肉蛋白的速度，并测量肌肉产生的信号变化是造成肌肉生长的原因。为了测量物理治疗的影响，无论有没有生长，我们将在手术后4天（在床上躺在床上）和一项物理治疗 +安慰剂或物理治疗或物理治疗 +生长促进营养溶液之前（躺在床上）之前4天（他们在第4天的疼痛和更多的活动）研究每个受试者的养分溶液。这些研究首先将使我们了解全膝关节置换手术对肌肉代谢的影响，并阐明该手术后用于恢复力量的传统方法（即物理疗法）。