CLINICAL CORRELATES OF LONGITUDINAL PET CHANGES IN ALZHEIMER'S DISEASE

阿尔茨海默病纵向 PET 变化的临床相关性

• 批准号: 7718404
• 负责人: MONY J. de LEON
• 金额: $ 0.22万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718404
• 关键词: Age-Years; Alzheimer' s Disease; Alzheimer' s disease risk; Brain; Clinical; Cognitive deficits; Computer Retrieval of Information on Scientific Projects Database; Detection; Deterioration; Elderly; Funding; Grant; Hippocampus (Brain); Hyperglycemia; Impaired cognition; Institution; Magnetic Resonance Imaging; Memory; Pathology; Performance; Population; Positron-Emission Tomography; Research; Research Personnel; Resources; Source; Testing; United States National Institutes of Health; base; entorhinal cortex; glucose metabolism; glucose transport; healthy volunteer; neuropsychological; pre-clinical; research clinical testing

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will attempt to identify the earliest predictors of memory and brain deterioration in preclinical Alzheimer's disease (AD) using FDG-PET. The hypothesis is that longitudinal reductions in glucose metabolism in the entorhinal cortex predict the onset of minimal cognitive impairment. Two groups of medically healthy elderly will be studied: one group will have evidence of memory decline. A third group will be normal healthy volunteers 20-30 years of age. For groups 1&2, clinical evaluations, a neuropsychological battery and Alzheimer's-associated cognitive deficits will be evaluated at baseline and at 36 months. PET and MRI will be performed at baseline and at 36 months to evaluate hippocampal pathology (MRI also at 18 months). Using this population, the following hypotheses will be tested: 1) Does enterorhinal cortex glucose metabolism predict decline in neuropsychological performance? 2) On the basis of observation of hyperglycemia-induced increase in glucose metabolism and memory in normal but not in AD, does decreased hippocampus glucose transport (evaluated under steady-state hyperglycemia and euglycemia) predict progressive brain deterioration? This study may help in the detection of subjects at risk for AD.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究将尝试使用FDG-PET确定临床前阿尔茨海默氏病（AD）中记忆和大脑恶化的最早预测指标。假设是，内嗅皮层中葡萄糖代谢的纵向减少预测了最小认知障碍的发作。 将研究两组医学健康的老年人：一组将有记忆力下降的证据。第三组将是正常健康的志愿者20-30岁。 对于第1组和第2组，临床评估，神经心理学电池和阿尔茨海默氏症相关的认知缺陷将在基线和36个月时评估。 PET和MRI将在基线和36个月时进行评估海马病理（MRI也在18个月时）。 使用该人群，将检验以下假设：1）肠肠性皮质葡萄糖代谢是否可以预测神经心理学表现的下降？ 2）基于观察高血糖引起的正常葡萄糖代谢和记忆的增加，但在AD中不降低，海马葡萄糖的转运（在稳态高血糖和耶酸糖症下评估）是否会预测渐进脑恶化？ 这项研究可能有助于检测有AD风险的受试者。