PREDICTORS OF COGNITIVE DECLINE IN NORMAL AGING

正常衰老过程中认知能力下降的预测因素

• 批准号: 7718402
• 负责人: MONY J. de LEON
• 金额: $ 0.37万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718402
• 关键词: Age-Years; Alleles; Alzheimer' s Disease; Atrophic; Brain Injuries; Brain imaging; Cognitive deficits; Computer Retrieval of Information on Scientific Projects Database; Disease; Elderly; Funding; Grant; Hippocampus (Brain); Impaired cognition; Institution; Length; Magnetic Resonance Imaging; Memory; Monitor; Pathology; Patients; Population; Research; Research Personnel; Resources; Risk; Source; Temporal Lobe; Testing; United States National Institutes of Health; apolipoprotein E-4; entorhinal cortex; healthy volunteer; hippocampal atrophy; image processing; mild neurocognitive impairment; neuropsychological; normal aging; research clinical testing

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The aim of this research is to identify a reliable marker that predicts cognitive impairment and progressive brain damage in the elderly. Specifically, atrophy of the perirhinal and entorhinal cortices of the hippocampus will be evaluated by MRI as an early marker of hippocampal atrophy and memory decline. Two groups of medically healthy elderly subjects will be studied; one group will be carriers of the ApoE4 allele. A third group will be normal healthy volunteers 20-30 years of age. Clinical evaluations, a neuropsychological battery and Alzheimer's-associated cognitive deficits will be evaluated at baseline, 18 and 36 months. MRIs will be done at 18 and 36 months to evaluate hippocampal pathology. Using this population, the following hypotheses will be tested: 1) In those at risk for Alzheimer¿¿s, is there a temporal sequence of atrophy of the hippocampus, with EC length change preceding hippocampal volume loss, which precedes temporal lobe atrophy? 2) Is EC length a predictor of longitudinal memory, and can this be used to classify patients into normal and minimally cognitively impaired? 3) In those carrying the ApoE4 allele, does evidence of baseline hippocampus atrophy predict a greater memory decline? Findings from this study may enhance our ability to detect subjects at risk for Alzheimer¿¿s disease (AD). Results thus far have demonstrated the importance of serial brain imaging and image processing in monitoring the early course of memory decline leading to mild cognitive impairment (MCI) and AD.

该副本是使用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这是调查员的机构。 这项研究的目的是确定一个可靠的标记物，该标记可以预测古老的认知障碍和逐渐损害的脑损伤。具体而言，MRI将评估海马的周围和内嗅皮层的萎缩，作为海马萎缩和记忆下降的早期标志。两组对医学健康的老年受试者将进行研究；一组将是APOE4等位基因的载体。第三组将是正常健康的志愿者20-30岁。临床评估，神经心理学电池和阿尔茨海默氏症相关的认知缺陷将在基线，18和36个月进行评估。 MRI将在18到36个月时进行评估海马病理。使用该人群，将检验以下假设：1）在有阿尔茨海默氏症风险的人中，海马萎缩的临时萎缩序列是否存在临时的海马体积损失之前，这是临时叶肉芽trobe骨的损失？ 2）EC长度是否是纵向记忆的预测指标，是否可以将患者分类为正常和最小的认知受损？ 3）在携带APOE4等位基因的人中，基线海马萎缩的证据是否预测记忆力较大？这项研究的结果可能会增强我们检测患阿尔茨海默氏病风险的受试者（AD）的能力。迄今为止，结果证明了串行脑成像和图像处理在监测记忆力下降的早期过程中的重要性，导致轻度认知障碍（MCI）和AD。