BIOMARKERS IN EARLY ALZHEIMER'S DISEASE

早期阿尔茨海默病的生物标志物

• 批准号: 7718414
• 负责人: MONY J. de LEON
• 金额: $ 0.43万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718414
• 关键词: Alzheimer' s Disease; Amyloid beta-Protein; Atrophic; Biological Markers; Computer Retrieval of Information on Scientific Projects Database; Data; Elderly; Enrollment; Evaluation; Funding; Grant; Hippocampus (Brain); Image; Impaired cognition; Individual; Institution; Invasive; Magnetic Resonance Imaging; Measurement; Measures; Memory; Neurofibrillary Tangles; Neurons; Research; Research Personnel; Resources; Source; Specificity; Spinal Puncture; Spinal Tap; Testing; United States National Institutes of Health; base; entorhinal cortex; improved; neuropsychological; size; tau Proteins; tau mutation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. It would be highly desirable to develop a non-invasive test for Alzheimer's disease (AD). The aim of this study is to use MRI and CSF biomarkers to identify in normal subjects the earliest clinically detected changes of AD. The hypothesis is that CSF P-tau levels will improve accuracy of MRI measurements of atrophy and CSF amyloid-beta measurements as a predictor of decline to cognitive impairment. The study is based on the observation that in some normal and minimally cognitively impaired individuals, neuronal and volume loss in the entorhinal cortex can be seen in association with neurofibrillary tangles. Imaging studies lack specificity, but the investigators suggest that tangle-related abnormal tau proteins (P-tau 231) are elevated in the CSF of minimally cognitively impaired individuals, predicting decline, and are specific for AD. This is a longitudinal MRI and CSF study over 3 years (3 evaluations) on 80 elderly normal subjects (50 with memory complaints) already enrolled in another study. MRI will be performed to measure hippocampus size. Lumbar puncture will be done to measure tau and amyloid-beta proteins. Standardized neuropsychological data will also be collected.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 对于阿尔茨海默氏病（AD）开发非侵入性测试是非常可取的。 这项研究的目的是使用MRI和CSF生物标志物在正常受试者中识别AD最早检测到的AD的变化。 假设是CSF P-TAU水平将提高萎缩和CSF淀粉样蛋白β测量值的MRI测量的准确性，以预测认知障碍的下降。 该研究基于这样的观察，即在某些正常和最小的认知受损的个体中，可以看到与神经原纤维缠结有关的内嗅皮层的神经元和体积损失。 成像研究缺乏特异性，但研究人员认为，与纠缠相关的异常TAU蛋白（P-TAU 231）在最小认知受损的个体的CSF中升高，预测了下降，并且针对AD。 这是对80名老年正常受试者（50名带记忆投诉）的纵向MRI和CSF研究，已经参加了另一项研究。 将执行MRI以测量海马大小。 将进行腰椎穿刺以测量tau和淀粉样蛋白蛋白质。 还将收集标准化的神经心理学数据。