LTQ Orbitrap Velos Mass Spectrometer System

LTQ Orbitrap Velos 质谱仪系统

• 批准号: 7838661
• 负责人: RUTH Hogue ANGELETTI
• 金额: $ 96.32万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-10 至 2011-06-09
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7838661
• 关键词: AIDS neuropathy; Communicable Diseases; Development; Diabetes Mellitus; Drug abuse; Environment; Funding; Health; Human; Laboratories; Malaria; Malignant Neoplasms; Mass Spectrum Analysis; National Institute of Drug Abuse; Obesity; Pathogenesis; Post-Translational Protein Processing; Proteomics; Request for Proposals; Resources; Scientist; System; Tuberculosis; instrument; mass spectrometer; neurotransmission; next generation; public health relevance

DESCRIPTION (provided by applicant): This proposal requests a Thermo Fisher Scientific LTQ Orbitrap Velos mass spectrometer system that will be utilized in projects important to human health, for example: pathogenesis of neuro-AIDS, tuberculosis, malaria and other infectious diseases; diabetes and obesity, cancer; and neurotransmission. The requested instrument is the next generation Orbitrap instrument that has features making it ideally suited for the projects proposed. These projects emphasize studies of quantitative proteomics and posttranslational modifications. This instrument will be utilized in an established mass spectrometry resource laboratory with highly skilled staff scientists in a highly interactive environment. The instrument system will also benefit the recently funded Einstein NIDA Proteomics Center on development of NeuroAIDS and drug abuse. PUBLIC HEALTH RELEVANCE: The requested instrument system will be utilized in projects important to human health, for example: pathogenesis of neuro-AIDS, tuberculosis, malaria and other infectious diseases; diabetes and obesity, cancer; and neurotransmission.

描述（由申请人提供）：该提案要求使用 Thermo Fisher Scientific LTQ Orbitrap Velos 质谱仪系统，该系统将用于对人类健康重要的项目，例如：神经艾滋病、结核病、疟疾和其他传染病的发病机制；糖尿病和肥胖、癌症；和神经传递。所需的仪器是下一代 Orbitrap 仪器，其功能使其非常适合拟议的项目。这些项目强调定量蛋白质组学和翻译后修饰的研究。该仪器将在一个已建立的质谱资源实验室中使用，该实验室由高技能的科学家在高度互动的环境中使用。该仪器系统还将有利于最近资助的爱因斯坦 NIDA 蛋白质组学中心，研究神经艾滋病和药物滥用的发展。 公共卫生相关性：所需的仪器系统将用于对人类健康重要的项目，例如：神经艾滋病、结核病、疟疾和其他传染病的发病机制；糖尿病和肥胖、癌症；和神经传递。

项目成果

Biochemical Characterization of the Mycobacterium smegmatis Threonine Deaminase.

• DOI: 10.1021/acs.biochem.8b00871
• 发表时间: 2018-09
• 期刊: Biochemistry
• 影响因子: 2.9
• 作者: L. Favrot;Tathyana M Amorim Franco;J. Blanchard