QTRAP 5500 Triple Quadrupole Mass Spectrometer System

QTRAP 5500 三重四极杆质谱仪系统

• 批准号: 7793808
• 负责人: RUTH Hogue ANGELETTI
• 金额: $ 48.93万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7793808
• 关键词: Advisory Committees; Anaerobic Bacteria; Collaborations; Development; Drug Kinetics; End stage renal failure; Ensure; Functional disorder; Future; Head and Neck Cancer; Health; Human; Human Resources; Maintenance; Malaria; Malignant Neoplasms; Metabolism; Pharmaceutical Preparations; Request for Proposals; Resources; System; experience; impaired glucose tolerance; instrument; mass spectrometer; operation; public health relevance; therapy outcome

DESCRIPTION (provided by applicant): This proposal requests an AB Sciex QTRAP 5500 triple quadrupole mass spectrometer system that will be utilized in projects important to human health, for example: development of new drugs for malaria and cancer, predictors for head and neck cancer outcome and therapy, metabolism of anaerobic bacteria, pathophysiology of impaired glucose tolerance, pharmacokinetics, and end stage renal disease. The requested instrument is an established, commercially available instrument that has features making it ideally suited for the projects proposed. The instrument will be located in a resource facility with longstanding experience and strong interactions and collaborations. Expert personnel will be responsible for operation and maintenance of the instrument. The administrative support, scientific personnel and advisory committee, plus strong institutional support will ensure effective utilization of the triple quadrupole mass spectrometer by the proposed and future projects. PUBLIC HEALTH RELEVANCE: The QTRAP 5500 triple quadrupole mass spectrometer system requested will be utilized in projects important to human health. These include: development of new drugs for malaria and cancer, predictors for head and neck cancer outcome and therapy, metabolism of anaerobic bacteria, pathophysiology of impaired glucose tolerance, and end stage renal disease.

描述（由申请人提供）：该提案要求使用 AB Sciex QTRAP 5500 三重四极杆质谱仪系统，该系统将用于对人类健康重要的项目，例如：开发治疗疟疾和癌症的新药、头颈癌结果的预测因子和治疗、厌氧菌代谢、糖耐量受损的病理生理学、药代动力学和终末期肾病。所请求的仪器是一种成熟的、可商用的仪器，其特性使其非常适合所提议的项目。该仪器将位于具有长期经验和强大互动与合作的资源设施中。专业人员将负责仪器的操作和维护。行政支持、科学人员和咨询委员会以及强大的机构支持将确保拟议项目和未来项目有效利用三重四极杆质谱仪。 公共健康相关性：所要求的 QTRAP 5500 三重四极杆质谱仪系统将用于对人类健康重要的项目。其中包括：疟疾和癌症新药的开发、头颈癌结果和治疗的预测因素、厌氧菌的代谢、糖耐量受损的病理生理学和终末期肾病。