Imaging Mass Spectrometry System

成像质谱系统

• 批准号: 8052462
• 负责人: RUTH Hogue ANGELETTI
• 金额: $ 58.63万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-10 至 2012-04-09
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8052462
• 关键词: Animal Model; Area; Basic Science; Biopsy; Cancer Biology; Communicable Diseases; Consequences of HIV; Disease; Drug abuse; Environment; Funding; Generations; HIV; Health; Human; Image; Immune; Kidney Diseases; Laboratories; Mass Spectrum Analysis; National Institute of Drug Abuse; Neoplasm Metastasis; Neurologic; Proteomics; Reproductive Biology; Request for Applications; Research; Research Personnel; Resources; Scientist; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Supervision; System; Tissues; Transgenic Animals; Translational Research; Zebrafish; experience; instrument; mutant; neurotransmission; response

DESCRIPTION (provided by applicant): This application requests an imaging mass spectrometry (IMS) system for basic and translational research important to human health. This instrument system will be used by a group of experienced investigators in the following research areas: 1) cancer biology, to investigate mechanisms of metastasis and invasion; 2) infectious diseases, to study the mechanisms of immune and tissue specific response to HIV, Tb, parasitic and fungal diseases; 3) renal disease; 4) neurotransmission; and 5) reproductive biology. Tissues from transgenic animal models, explants, and biopsies will be studied, as well as intact zebrafish mutants. The requested instrument is an UltrafleXtreme(tm) MALDI- TOF/TOF system from Bruker Daltonics that has features making it ideally suited for the projects proposed. The projects will take advantage of the capabilities of the UltrafleXtreme(tm), and be enabled in their hypothesis generation and discovery by its use. This instrument will be located in an established mass spectrometry resource laboratory under the supervision of a highly skilled investigator with the support of excellent staff scientists in a highly interactive and supportive environment. The instrument system will also benefit the recently funded Einstein NIDA Proteomics Center on the neurological consequences of HIV and drug abuse.

描述（由申请人提供）：本申请要求对人类健康至关重要的基本和转化研究成像质谱（IMS）系统。一组经验丰富的研究人员将在以下研究领域使用该仪器系统：1）癌症生物学，以研究转移和侵袭机制； 2）传染病，研究对HIV，TB，寄生和真菌疾病的免疫和组织特异性反应的机制； 3）肾脏疾病； 4）神经传递； 5）生殖生物学。将研究来自转基因动物模型，外植体和活检的组织，以及完整的斑马鱼突变体。该请求的仪器是Bruker Daltonics的Ultraflextreme（TM）Maldi-Tof/TOF系统，其功能使其非常适合提议的项目。这些项目将利用Ultraflextreme（TM）的功能，并在其假设生成和发现中启用。该工具将在高度熟练的研究人员的监督下，在高度互动和支持性的环境中的优秀员工科学家的支持下，将位于既定的质谱资源实验室中。该仪器系统还将受益于最近资助的Einstein NIDA蛋白质组学中心对艾滋病毒和药物滥用的神经系统后果。