Comprehensive portrait of long-term cannabis users: Are they ready for old age?

长期大麻使用者的全面画像：他们准备好迎接老年了吗？

• 批准号: 10088914
• 负责人: TERRIE E MOFFITT
• 金额: $ 32.29万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-12-15 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10088914
• 关键词: 3-Dimensional; Adolescent; Adult; Age; Aging; Algorithms; Alzheimer' s Disease; Alzheimer' s disease risk; Anxiety; Area; Attention deficit hyperactivity disorder; Biological Aging; Biological Markers; Blood; Brain; Cannabis; Cardiovascular system; Childhood; Cities; Clinical; Cognitive; Computerized Medical Record; DNA Methylation; Data; Data Analyses; Data Set; Development; Dimensions; Discipline; Disease; Drug Prescriptions; Elderly; Epigenetic Process; Future; Government; Headache; Health; Hepatic; Individual; Individual Differences; Infant; Injury; Interest Group; Interview; Kidney; Life; Logic; Lung; Magnetic Resonance Imaging; Maintenance; Marijuana Dependence; Measures; Mediation; Mental Depression; Mental Health; Metabolic; Methods; Methylation; Modeling; Motor; Musculoskeletal Pain; National Institute of Drug Abuse; Neuropsychology; Pain; Participant; Pattern; Personal Satisfaction; Portraits; Positioning Attribute; Prevention; Process; Prospective Studies; Publications; Publishing; Quality of life; Recording of previous events; Records; Research; Risk; Sampling; Savings; Secure; Services; Sleep; Structure; Surface; Taxes; Testing; Thick; Work; age related; aging brain; alcohol abuser; baby boomer; base; body system; brain abnormalities; cognitive ability; cognitive reserve; cognitive testing; cohort; convict; cost; disorder risk; experience; financial literacy; genome-wide; gray matter; health literacy; healthspan; human old age (65+); immune function; innovation; insurance claims; interest; marijuana use; marijuana user; medical examination; member; middle age; mortality; neuroimaging; novel; physical conditioning; physical inactivity; prospective; relating to nervous system; sleep quality; socioeconomics; tobacco smokers; welfare; white matter; whole genome

This R01 application responds to FOA PA-18-061: Marijuana Use In Older Adults. Baby- boomers who began using cannabis as young people, and who have continued cannabis use for years, are now entering later life. The FOA prioritizes new evidence about the current risk status of life-long cannabis users in relation to the aging process, and the aging brain, including potential risk for Alzheimer’s disease and related disorders. How prepared are they for successful aging and a long healthspan in late life? We propose to characterize midlife reserve status of long-term cannabis users in the Dunedin Study, a cohort of 1037 infants born in one city in 1972-73 and studied to age 45 in 2019, with 94% retention. There have been 8 waves of in-depth clinical cannabis-use interviews from age 13 to age 45, a unique asset for defining the users who are the target of this FOA. Our primary group of interest are the cohort members who have used cannabis weekly-to-daily for the past 3 decades, three-quarters of whom have met cannabis-dependence criteria. We will test whether such long-term cannabis users do or do not show diminished reserve capacities in midlife, including accelerated biological aging. Accelerated aging and diminished reserve pose risk for poor quality of life, brief health span, and early mortality. The project’s novel conceptual framework extends the logic of “protective cognitive reserve capacities” to a range of other life domains: we will study reserve in tested cognitive abilities, but also reserve in neural structure and connectivity assessed through neuroimaging, physical-health reserve assessed in clinical medical examinations, epigenetic- maintenance reserve assessed as genome-wide DNA methylation, and financial reserves assessed through interviews, credit ratings and tax records. In addition to analyses of continuous dimensional measures, analyses will uniquely be able to compare long-term cannabis users against 5 informative groups: lifelong non-users, midlife recreational users, formerly cannabis-dependent quitters, cannabis-free long-term alcohol-abusers, and cannabis- free long-term tobacco-smokers. For many of the project’s Aims, the Dunedin Study’s prospective repeated measures allow the rare advantage of comparing long-term users against themselves at a younger age, before prolonged cannabis exposure. Innovations are: (1) cannabis-use histories validly defined with 4 decades of prospective assessments, (2) our conceptual framework of “reserve” for future aging, (3) a comprehensive portrait of participants’ reserve status on aging-relevant measures across multiple disciplines, collected in the same individuals.

此R01对FOA PA-18-061的申请响应：老年人使用大麻。婴儿- 开始使用大麻并继续使用大麻的婴儿潮一代 多年来，现在正在进入以后的生活。 FOA优先考虑有关当前风险的新证据 终身大麻使用者与衰老过程以及衰老大脑有关的状态，包括 阿尔茨海默氏病和相关疾病的潜在风险。他们为 成功的衰老和后期的长期健康状况？我们建议描述中年储备 Dunedin研究中长期大麻使用者的状态，这是一组1037名婴儿 1972 - 73年的城市，2019年为45岁，保留94％。有8波 从13岁到45岁的深入临床大麻访谈，这是定义的独特资产 是此FOA的目标的用户。我们的主要兴趣小组是队列成员 在过去的三十年中，每周一次到每周都使用大麻，其中四分之三见面了 大麻依赖性标准。我们将测试如此长期的大麻用户是否这样做 显示中年的储备能力降低，包括加速的生物衰老。 加速衰老和减少的储备会构成生活质量差的风险，新短暂的健康跨度， 和早期死亡率。该项目的新颖概念框架扩展了“保护性的逻辑” 认知储备的能力”到其他一系列生命领域：我们将在经过测试中学习储备 认知能力，但也保留通过神经元结构和连通性评估 在临床医学检查中评估的神经影像学，物理健康储量，表观遗传学 - 维护储量储备储量评估为全基因组DNA甲基化和财务储量 通过访谈，信用评级和税收记录进行评估。除了分析 连续维度测量，分析将能够比较长期 针对5个有益组的大麻用户：终身非用户，中年娱乐用户， 以前依赖大麻的戒烟，无大麻的长期饮酒者和大麻 免费的长期烟草烟民。对于该项目的许多目标，但尼丁研究 预期的重复措施允许将长期用户与 自己年轻，在长时间大麻暴露之前。创新是：（1） 大麻使用历史有效地定义了40年的前瞻性评估，（2）我们 未来衰老的“储备”的概念框架，（3）参与者的全面肖像 跨多个学科的相关测量的预留状态，以相同的方式收集 个人。