Is mental disorder a preventable cause of age-related disease? The Dunedin Study.

精神障碍是与年龄相关的疾病的可预防原因吗？

基本信息

批准号：
8423723
负责人：
TERRIE E MOFFITT
金额：
$ 44.48万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-03-01 至 2015-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8423723
关键词：
Adolescence Adult Affect Age Aging Alcohol abuse Alcohol dependence American Anxiety Anxiety Disorders Atherosclerosis Attention Behavior Behavioral Medicine Biological Biological Markers Birth Books C-reactive protein Cardiovascular Diseases Carmine Cause of Death Cell division Cerebrovascular Disorders Child Chromosomes Chronic Chronic Schizophrenia Clinical Clinical Research DNA DNA Sequence Data Data Collection Dementia Development Diabetes Mellitus Diagnosis Disease Dyslipidemias Elderly Epidemiologic Studies Expectancy Family history of Fibrinogen Finches Fostering Gender General Population Goals Half-Life Health Health Status Heart Diseases Hypertension Immune System Diseases Immunology Impaired cognition Impairment Individual Inflammation Inflammatory Insulin Resistance Interleukin-6 Learning Length Life Life Cycle Stages Life Expectancy Life Experience Longitudinal Studies Major Depressive Disorder Malignant Neoplasms Marijuana Dependence Measurement Measures Memory Mental Depression Mental Health Mental Tests Mental disorders Metabolic Metabolic syndrome Mind Molecular Morbidity - disease rate NIH Program Announcements Neuropsychological Tests Neuropsychology Non-Insulin-Dependent Diabetes Mellitus Obesity Onset of illness Outcome Outcome Measure Outcome Study Parents Pathogenesis Pathway interactions Patients Physiological Policy Maker Population Premature aging syndrome Prevention Primary Prevention Prognostic Marker Publications Recording of previous events Recurrence Research Risk Risk Factors Role Schedule Schizophrenia Science Series Services Severities Sex Characteristics Short-Term Memory Signal Transduction Stroke Substance Addiction Syndrome System Telomere Shortening Testing Time Trust Variant Woman Women&apos s Health Work Writing age related anti social base body system carbohydrate metabolism cohort design disability emerging adult executive function falls fitness follow-up frailty grandparent immune function improved indexing inflammatory marker innovation interest lipid metabolism meetings member men middle age mortality neuropsychological novel older men older women perceptual organization physical conditioning prevent processing speed prognostic programs prospective protein structure recurrent depression senescence sex skills social telomere

项目摘要

DESCRIPTION (provided by applicant): We propose to test the novel hypothesis that a persistent history of psychiatric disorder might accelerate individuals' risk of progression toward age-related disease. Specifically, the hypothesis is that people who suffer chronic or recurrent psychiatric disorders during early adulthood will, already by age 38, show cognitive decline and abnormal status on sub-clinical biomarkers that are known to be prognostic early warning signs for late-life diseases, frailty and disability. Rather than focus on psychiatric disorders as an outcome, we study psychiatric disorders as a potentially preventable `exposure' that may accelerate aging. METHOD: We will test this hypothesis in the context of the Dunedin Study, a longitudinal study from birth to age 38 of a representative birth cohort of men and women (N=1037). A unique design feature is that baseline physical health and baseline neuropsychological assessments were carried out from birth to age 13, prior to the onset of most psychiatric disorders. To our knowledge, no other study of the health consequences of psychiatric disorder has these prospective baseline data, which are essential to test whether health and neuropsychological functions have deteriorated in individuals with persistent psychiatric disorder. Cohort members' psychiatric histories of recurrent Depression, recurrent Anxiety, chronic Schizophrenia-syndrome, persistent Alcohol Dependence, and persistent Cannabis Dependence will be defined using data from repeated assessments across 20 intervening years in this longitudinal study. Here we propose to assess the cohort again at age 38, for new data collection. We will assess sensitive outcome measures of sub-clinical health status that are known predictors of age-related diseases in later life: neuropsychological tests of memory and executive functions, the metabolic syndrome, immunological biomarkers, and shortened telomere length. These markers were chosen because they show meaningful variation among people in their late 30's and are known early warning signs for dementia, cardiovascular disease and diabetes. INNOVATION AND SIGNIFICANCE: Life expectancy is growing longer and longer. Policy makers and citizens are concerned that our extra years of life should be healthy, productive, and enjoyable, not extra years of disease and disability. The hope of preventing age-related diseases and of increasing health expectancy requires research to identify candidate risk targets that can be treated successfully, in early- to-middle adulthood. If the hypothesis that psychiatric disorder accelerates the sub-clinical progression toward age-related disease were shown to be true by our proposed research, this would imply that age- related disease could be reduced by successfully treating psychiatric disorders early in life.

描述（由申请人提供）：我们建议检验以下新的假设，即精神疾病的持续史可能会加速个人向年龄相关疾病发展的风险。具体而言，假设是，在成年初期遭受慢性或复发性精神疾病的人已经在38岁时已经显示出对次临床生物标志物的认知能力下降和异常状态，而后临床生物标志物已知是后期疾病，脆弱和残疾的预后预警迹象。我们并没有将精神疾病作为一种结果，而是将精神疾病研究为可能加速衰老的可能可预防的“暴露”。方法：我们将在达尼丁研究的背景下检验这一假设，这是一项纵向研究，从出生到38岁的男性和女性出生队列（n = 1037）。一个独特的设计特征是，在大多数精神疾病发作之前，基线身体健康和基线神经心理学评估是从出生到13岁进行的。据我们所知，对精神疾病的健康后果的其他研究没有其他前瞻性基线数据，这对于测试持续性精神疾病的人的健康和神经心理学功能是否恶化至关重要。队列成员的复发性抑郁症，复发性焦虑，慢性精神分裂症合成，持续性酒精依赖和持续性大麻依赖性的精神病学历史将使用在这项纵向研究的20年中的20年中的重复评估中定义。在这里，我们建议在38岁时再次评估该队列，以进行新的数据收集。我们将评估次临床健康状况的敏感结果度量，这是后来生活中与年龄相关疾病的已知预测指标：记忆和执行功能的神经心理学测试，代谢综合征，免疫生物标志物和缩短的端粒长度。之所以选择这些标记是因为它们在30年代后期显示出有意义的差异，并且是痴呆症，心血管疾病和糖尿病的已知预警信号。创新和意义：预期寿命越来越长。决策者和公民担心我们的额外生活应该是健康，富有成效和愉快的，而不是多年的疾病和残疾。希望预防与年龄相关的疾病和增加健康状况的希望需要研究来确定可以在早期成年期间成功治疗的候选风险目标。如果我们提出的研究表明，关于精神疾病加速对年龄相关疾病的次临界进展的假设是正确的，这将暗示可以通过在生命早期成功治疗精神疾病来减少与年龄相关的疾病。