Attentional control in children who stutter

口吃儿童的注意力控制

• 批准号: 10055438
• 负责人: Amanda M Hampton Wray
• 金额: $ 15.62万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-05 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10055438
• 关键词: Attentional; control; children; who; stutter

PROJECT SUMMARY Stuttering is a neurodevelopmental disorder with devastating consequences on communication and quality of life. The etiology of stuttering is influenced by dynamic interactions between genetic and epigenetic factors, including speech motor control, emotion regulation, cognitive-linguistic processes, and environmental factors. The current project focuses on attentional control in children who stutter (CWS), a cognitive skill critical for regulating and maintaining attention toward a stimulus or task. Atypical attentional control in CWS, indicated by theoretical models of stuttering, is supported by recent empirical evidence of atypical neural connectivity between attention and somatomotor networks. However, it is not yet known how these atypical connectivity patterns impact neural functions for attention in CWS, which may impact fluent speech productions. Reduced or discoordinated attentional control in CWS, who have vulnerable speech motor systems, may contribute to disfluent speech by affecting initiation or maintenance of the goal-directed actions of speech production. The current proposal extends previous behavioral and neuroimaging findings in CWS by evaluating distinct attentional control systems in the same child to elucidate the nature of attentional control in 5- to 8-year-old CWS. Three distinct attentional control systems, which together regulate attention, will be assessed: Alerting (response to a stimulus), Orienting (directing toward a stimulus), and Executive Control (maintaining goal- directed behaviors and response inhibition). Attentional control will be evaluated using a battery of behavioral and neurophysiological tasks. The specific aims of this proposal are: (1) Characterize and contrast neural processes underlying distinct attentional control systems in CWS and fluent peers. Neurophysiological data (event-related brain potentials [ERPs]) will be acquired during attentional control tasks to evaluate the effects of distinct attentional control system on neural processing. (2) Characterize and contrast attentional control profiles in CWS and fluent peers. A battery of multiple and complementary tasks will evaluate performance on distinct attentional control tasks. (3) Develop and evaluate a preliminary model of attentional control in CWS. Relationships between ERP and behavioral performance as well as parental reports of behavior in CWS will be used to construct latent attentional control factors and determine which of these factors most strongly predicts stuttering severity. Including parental reports will support translation of our findings to clinical settings. This project will establish whether distinct attentional control systems, or attentional control more broadly, are atypical in CWS. This project will lay the groundwork for future research informing two long-term goals: 1) The evaluation of changes in attentional control over time in younger CWS, leading to refinement of predictive factors of persistence versus recovery, and 2) The enhancement of traditional treatment approaches to incorporate attention systems that differ in CWS and most strongly predict stuttering severity, thereby informing development of evidence-based treatment programs with the greatest potential to maximize outcomes in CWS.

项目摘要 口吃是一种神经发育障碍，对沟通和质量造成破坏性后果 生活。口吃的病因受遗传和表观遗传因素之间的动态相互作用的影响， 包括语音运动控制，情绪调节，认知语言过程和环境因素。 当前的项目着重于口吃（CWS）的儿童的注意力控制，这是一种至关重要的认知技能 调节并保持注意刺激或任务。 CWS中的非典型注意力控制，指示 通过口吃的理论模型，非典型神经连通性的最新经验证据支持 在注意力和体面运动网络之间。但是，尚不知道这些非典型连接如何 模式会影响CWS注意力的神经功能，这可能会影响流利的语音作品。减少 或具有脆弱的语音运动系统的CWS中的不符合注意力控制可能有助于 通过影响语音生产的目标指导行动的启动或维护来表达言语。 当前的建议通过评估不同 同一孩子的注意控制系统，以阐明5至8岁的注意力控制的性质 CWS。将评估三个不同的注意控制系统，共同调节注意力：提醒 （对刺激的反应），定向（指向刺激）和执行控制（保持目标 - 定向行为和反应抑制）。将使用一系列行为来评估注意力控制 和神经生理任务。该提案的具体目的是：（1）表征和对比神经 CWS和Fluent同行中不同注意力控制系统的过程。神经生理数据 （事件相关的大脑电位[ERP]）将在注意力控制任务期间获取以评估效果 关于神经处理的不同注意力控制系统。 （2）表征和对比度注意控制 CWS和流利的同行中的轮廓。一组多个互补任务将评估性能 独特的注意力控制任务。 （3）开发和评估CWS注意控制的初步模型。 ERP与行为表现之间的关系以及CWS行为的父母报告将是 用于构建潜在注意力控制因素并确定这些因素中的哪些最强烈预测 口吃的严重程度。包括父母的报告将支持我们的发现转换为临床环境。 该项目将确定明显的注意控制系统或更广泛的注意力控制 在CWS中是非典型的。该项目将为未来的研究奠定基础，以告知两个长期目标：1） 评估年轻CW中注意力控制随时间的变化，导致预测性的完善 持久性与恢复的因素，以及2）增强传统治疗方法 结合了CWS不同并最强烈预测口吃严重性的注意力系统，从而告知 制定基于证据的治疗计划，其最大程度地提高了CWS的结果。