sTMS for Substance Use-disordered Veterans

针对药物使用障碍退伍军人的 sTMS

• 批准号: 10006926
• 负责人: JOHN E MCGEARY
• 金额: --
• 依托单位: PROVIDENCE VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10006926
• 关键词: Alcohol or Other Drugs use; Alcohol withdrawal syndrome; Alcohols; Behavior Therapy; Biological; Brain; Calibration; Clinical Trials; Cocaine; Cues; Devices; Disease; Dropout; Electricity; Feasibility Studies; Foundations; Future; Genetic; Goals; Impairment; Infrastructure; Intervention; Measures; Mental Health; Modality; Opioid; Participant; Pharmacological Treatment; Pharmacology; Pharmacotherapy; Pilot Projects; Population; Protocols documentation; Psychotherapy; Quality of life; Rehabilitation therapy; Relapse; Risk; Safety; Standardization; Substance Use Disorder; Techniques; Testing; Transcranial magnetic stimulation; Treatment Cost; Treatment outcome; United States; Veterans; Work; addiction; alcohol use disorder; craving; cue reactivity; design; genome sciences; improved; improved outcome; neural circuit; neuroregulation; neurorestoration; neurotechnology; novel strategies; opioid use; psychostimulant; reduced substance use; rehabilitation research; repetitive transcranial magnetic stimulation; response; success

The goal of this proposal is to evaluate preliminary participant response to a pilot, controlled, feasibility study to evaluate changes in craving, substance use, and quality of life after 6 weeks of a low-risk non-invasive brain stimulation technique, called Synchronized Transcranial Magnetic Stimulation (sTMS), compared to sham, in Veterans with a substance use disorder (SUD). An important focus of this application will be evaluating the acceptability, tolerability, and safety of sTMS in this population. To our knowledge, sTMS has never been used for SUDs, and holds considerable promise as a future treatment option for these prevalent disorders. However initial work in the acceptability, tolerability, and safety of this approach must be conducted first. This project is the first step towards our long-term goal, which is to combine non-invasive brain stimulation with individualized psychotherapy or pharmacotherapy to reduce SUD problems and improve quality of life for Veterans.

该提案的目标是评估参与者对试点、受控、 可行性研究，评估 6 周后的渴望、物质使用和生活质量的变化 一种低风险的非侵入性脑刺激技术，称为同步经颅 与假手术相比，对患有物质使用障碍的退伍军人进行磁刺激 (sTMS) （南苏丹）。该应用程序的一个重要重点是评估可接受性、耐受性和 sTMS 在该人群中的安全性。据我们所知，sTMS 从未用于 SUD，并且 作为这些流行疾病的未来治疗选择，前景广阔。然而 必须首先开展该方法的可接受性、耐受性和安全性方面的初步工作。 这个项目是我们实现长期目标的第一步，即结合非侵入性大脑 通过个体化心理治疗或药物治疗进行刺激，以减少 SUD 问题 提高退伍军人的生活质量。