sTMS for Substance Use-disordered Veterans

针对药物使用障碍退伍军人的 sTMS

• 批准号: 10663804
• 负责人: JOHN E MCGEARY
• 金额: --
• 依托单位: PROVIDENCE VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10663804
• 关键词: Alcohol withdrawal syndrome; Alcohols; Behavior Therapy; Biological; Brain; Calibration; Clinical Trials; Cocaine; Cues; Devices; Disease; Dropout; Electricity; Feasibility Studies; Future; Genetic; Goals; Impairment; Infrastructure; Intervention; Measures; Mental Health; Modality; Opioid; Participant; Pharmacological Treatment; Pharmacotherapy; Pilot Projects; Population; Protocols documentation; Psychotherapy; Quality of life; Rehabilitation therapy; Relapse; Research Proposals; Risk; Safety; Standardization; Substance Use Disorder; Techniques; Testing; Transcranial magnetic stimulation; Treatment Cost; Treatment outcome; United States; Veterans; Work; acceptability and feasibility; addiction; craving; cue reactivity; design; feasibility testing; genome sciences; improved; improved outcome; neural circuit; neuroregulation; neurorestoration; neurotechnology; noninvasive brain stimulation; novel strategies; pharmacologic; reduced substance use; rehabilitation research; repetitive transcranial magnetic stimulation; response; stimulant dependence; substance use; substance use treatment; success

The goal of this proposal is to evaluate preliminary participant response to a pilot, controlled, feasibility study to evaluate changes in craving, substance use, and quality of life after 6 weeks of a low-risk non-invasive brain stimulation technique, called Synchronized Transcranial Magnetic Stimulation (sTMS), compared to sham, in Veterans with a substance use disorder (SUD). An important focus of this application will be evaluating the acceptability, tolerability, and safety of sTMS in this population. To our knowledge, sTMS has never been used for SUDs, and holds considerable promise as a future treatment option for these prevalent disorders. However initial work in the acceptability, tolerability, and safety of this approach must be conducted first. This project is the first step towards our long-term goal, which is to combine non-invasive brain stimulation with individualized psychotherapy or pharmacotherapy to reduce SUD problems and improve quality of life for Veterans.

该建议的目的是评估对飞行员的初步参与者的反应，受控， 可行性研究以评估6周后渴望，药物使用和生活质量的变化 低风险的非侵入性脑刺激技术，称为同步经颅 与假手术的磁刺激（STM）相比，具有物质使用障碍的退伍军人 （SUD）。本应用程序的一个重要重点是评估可接受性，耐受性和 STM在该人群中的安全。据我们所知，STM从未用于SUD，并且 作为这些普遍疾病的未来治疗选择，具有相当大的希望。然而 必须首先进行这种方法的可接受性，耐受性和安全性。 该项目是迈向我们长期目标的第一步，即结合非侵入性大脑 通过个性化的心理治疗或药物疗法刺激，以减少SUD问题和 改善退伍军人的生活质量。