Yale Drug Abuse, Addiction, and HIV Research Scholars (Yale-DAHRS)

耶鲁大学药物滥用、成瘾和艾滋病毒研究学者 (Yale-DAHRS)

• 批准号: 8650799
• 负责人: Gail D'Onofrio
• 金额: $ 50.18万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-15 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8650799
• 关键词: AIDS prevention; Accident and Emergency department; Acquired Immunodeficiency Syndrome; Acute; Address; Adolescent; Aging; Alcohol or Other Drugs use; Alcohols; Area; Behavioral Research; Biomedical Research; Buprenorphine; Cardiovascular Diseases; Chronic; Clinic; Clinical Informatics; Clinical Research; Clinical Sciences; Clinical Trials; Communicable Diseases; Communities; Community Hospitals; Complex; Data Analyses; Data Collection; Data Set; Demography; Development; Development Plans; Diagnostic; Discipline of obstetrics; Disease; Drug Addiction; Drug abuse; Effectiveness; Elderly; Emergency Medicine; Engineering; Ensure; Evaluation; Faculty; Federally Qualified Health Center; Fostering; Foundations; Funding; Future; Gender; Grant; Gynecology; HIV; Health; Health Sciences; Hepatitis; Hepatitis C; Hospitals; Imprisonment; Information Dissemination; Inpatients; Institutes; Interdisciplinary Study; Internal Medicine; Intervention; Intoxication; Investigation; Knowledge; Laboratories; Leadership; Lung diseases; Medical; Medical center; Medicine; Mentors; Meta-Analysis; Minority; Modeling; NCI Scholars Program; New England; Opiate Addiction; Outcome; Overdose; Pain; Patients; Pediatrics; Population Heterogeneity; Prevention; Primary Health Care; Principal Investigator; Provider; Psychiatry; Psychology; Public Health Informatics; Publishing; Research; Research Infrastructure; Research Methodology; Research Personnel; Research Priority; Research Project Grants; Research Training; Risk; Risk Factors; Science; Scientist; System; Time; Tobacco; Training; Training Programs; Trauma; United States National Institutes of Health; Veterans; Withdrawal; Woman; Women' s Health; Work; Writing; addiction; base; career; career development; clinical epidemiology; cohort; cost effective; data management; design; experience; improved; innovative technologies; named group; post-doctoral training; prescription drug abuse; programs; racial and ethnic disparities; responsible research conduct; screening; screening, brief intervention, referral, and treatment; skills; statistics; success; systematic review; tertiary care; tool; tool development; treatment center; ward

DESCRIPTION (provided by applicant): There is a critical need to develop a diverse pool of highly trained clinician scholars to foster the development of biomedical, behavioral and clinical research related to drug abuse, addiction, and HIV prevention and treatment in general medical settings. Patients who abuse substances are more likely to be seen in general medical settings such as emergency departments (ED), general medical primary care clinics and inpatient wards, HIV and adolescent health clinics, and women's health centers. These patients often present with a complex array of acute consequences and complications (e.g. intoxication, overdose, withdrawal, trauma and infectious diseases) of substance use as well as chronic conditions such as HIV disease, hepatitis, pulmonary and cardiovascular disease. Objectives: The Yale-Drug Abuse, Addiction, and HIV Research Scholars (DAHRS) program provides a comprehensive three year post-doctorate, interdisciplinary, Mentored Career Development Program to improve drug abuse, addiction, and HIV medical outcomes integrating prevention and treatment in general medical settings including ED, primary care, HIV, adolescent, and women's health clinics. Specifically, Yale-DAHRS will: [Aim 1] Develop clinician scientists with the knowledge, skills, and ability to become independent investigators, generating findings of practical value with significant impact to improve health outcomes of patients with and at risk for drug abuse, addiction, and HIV; [Aim 2] Develop future leaders by providing Scholars with leadership tools and skills and creating individualized programs to ensure success in leading multidisciplinary research teams in studying drug abuse, addiction and HIV, and implementation and integration of research findings into general medical settings; and [Aim 3] Enhance the diversity of drug abuse, addiction, and HIV researchers. Addressing women and minority faculty under representation will enhance the diversity of investigators and research topics, broaden perspectives in setting research priorities, increase clinical trial participation, and expand knowledge. Working synergistically with Yale's established training programs in drug abuse, HIV and clinical investigation, Yale- DAHRS will capitalize on existing academic infrastructure and expertise to ensure success. Unique, features include: (1) An interdisciplinary, diverse faculty of independent researchers in illicit and prescription drug abuse and addiction, tobacco, alcohol, HIV, and medical complexities such as pain and hepatitis C; (2) Synergy with well established, high quality post-doctoral training programs at Yale; (3) The use of clinical informatics for data collection, data management, diagnostic tool development, and information dissemination; and (4) The integration of such diverse fields as public health, informatics, clinical epidemiology, systems engineering and demography with the traditional clinical sciences of internal medicine, emergency medicine, HIV medicine, pediatrics, obstetrics and gynecology, psychiatry, and psychology; (5) Established clinical research laboratories, including the Yale-New Haven Hospital, a tertiary care center for southern New England and a community hospital for the Greater New Haven Area, serving an ethnically, racially, culturally, and economically diverse population, a Veterans Affairs Medical Center and community treatment centers such as the APT Foundation and Federally Qualified Health Centers; (6) Synergies with established research centers and institutes such as the Center for Interdisciplinary Research on AIDS and the Veterans Aging Cohort on HIV. Career Development Plan: Yale-DAHRS is a three year research training program that will prepare a total of six clinician investigators for careers focusing on drug abuse, addiction, and HIV in general medical settings during its first funding cycle. Scholars will earn the Master in Health Sciences degree, combining rigorous training in research methodology, statistics and design with seminars in topics related to drug abuse, addiction, and HIV content, leadership, grant writing and responsible conduct of research. Candidates will complete published mentored research project(s) and prepare an application for the next career step; i.e. NIH R21, R03, R15, R34 mechanism. The collaboration of the multidisciplinary faculty and the combined robust strengths of two principal investigators from Emergency and Internal Medicine, both with extensive experience mentoring and as independent funded investigators will drive the Yale-DAHRS program. Potential Research Projects: Multiple research projects are "shovel ready" for Scholar training and can be completed within our allotted time frame, such as secondary data analysis using national large datasets e.g. VA Aging Cohort (HIV); risk factors, prevention and treatment of prescription drug abuse, office-based treatment of opioid dependence with buprenorphine, systematic reviews and meta-analyses, creation of cost effective evaluation models for patients with drug abuse, addiction and HIV including prescription drug abuse; investigation of gender and racial/ethnic disparities in identification and treatment interventions and outcomes; evaluation of screening, and treatment initiation in special populations (i.e. adolescent-elderly, veterans, incarcerated, HIV); comparison of models of screening, brief intervention and referral to treatment (SBIRT) delivery by providers and other innovative technologies; effectiveness and implementation of SBIRT science in general medicine practice with acute and chronic medical complexities.

描述（由申请人提供）：迫切需要开发多种训练有素的临床医生，以促进与药物滥用，成瘾以及预防艾滋病毒预防和治疗的生物医学，行为和临床研究的发展。滥用滥用物质的患者更有可能在一般医疗机构（例如急诊科（ED），一般医疗初级保健诊所和住院病房，艾滋病毒和青少年健康诊所以及妇女保健中心）中看到。这些患者经常出现一种复杂的急性后果和并发症（例如中毒，过量，戒断，创伤和传染病），以及诸如HIV病，肝炎，肺部和心血管疾病等慢性病。目标：耶鲁大学的滥用，成瘾和艾滋病毒研究学者（DAHRS）计划提供了一项全面的后三年，跨学科的，指导的职业发展计划，以改善药物滥用，成瘾和HIV医疗结果，从而整合预防和治疗。包括ED，初级保健，艾滋病毒，青少年和妇女健康诊所在内的医疗环境。具体而言，耶鲁 - 达尔（Yale-Dahrs）将：[AIM 1]开发具有知识，技能和能力成为独立研究人员的临床医生，产生具有重大影响的实践价值的发现，以改善有和有风险的患者的健康成果 吸毒，成瘾和艾滋病毒； [AIM 2]通过为学者提供领导工具和技能，并创建个性化计划，以确保在研究吸毒，成瘾和艾滋病毒，以及将研究结果的实施和整合到一般医疗环境中，以确保成功地发展未来的领导者； [AIM 3]增强了药物滥用，成瘾和艾滋病毒研究人员的多样性。针对代表的妇女和少数族裔教职员工将提高研究人员和研究主题的多样性，扩大研究优先事项的观点，增加临床试验参与并扩大知识。耶鲁大学将与耶鲁大学既定的药物滥用，艾滋病毒和临床调查的培训计划协同工作，将利用现有的学术基础设施和专业知识，以确保成功。独特的功能包括：（1）跨学科的，多元化的教师 非法和处方药物滥用和成瘾，烟草，酒精，艾滋病毒和医学复杂性（例如疼痛和乙型肝炎）的独立研究人员； （2）与耶鲁大学建立高质量的博士后培训计划协同作用； （3）将临床信息学用于数据收集，数据管理，诊断工具开发和信息传播； （4）将公共卫生，信息学，临床流行病学，系统工程和人口统计学等各种领域与传统的内科临床科学，急诊医学，HIV医学，儿科，妇产科和妇科，精神病学和心理学的融合在一起； （5）已建立的临床研究实验室，包括耶鲁 - 新避风港医院，新英格兰南部的三级护理中心以及大纽黑文地区的社区医院，在种族，种族，文化和经济上多样化的人口，退伍军人服务事务医疗中心和社区治疗中心，例如APT基金会和联邦资格的保健中心； （6）与已建立的研究中心和机构的协同作用，例如艾滋病跨学科研究中心和艾滋病毒老年人群的老年人群。职业发展计划：耶鲁·戴尔斯（Yale-Dahrs）是一项为期三年的研究培训计划，该计划将为六名临床医生研究人员准备在第一个融资周期中的一般医疗环境中专注于药物滥用，成瘾和艾滋病毒的职业。学者将获得健康科学硕士学位，将研究方法，统计学和设计中的严格培训与与药物滥用，成瘾和艾滋病毒内容有关的主题，领导力，领导力，授予写作和负责任的研究进行的主题研讨会。候选人将完成已发表的指导研究项目，并为下一个职业步骤准备申请；即NIH R21，R03，R15，R34机制。跨学科教师的合作以及两名来自紧急情况和内科医学的主要研究人员的合理优势，包括丰富的经验，并且作为独立的资助研究人员将推动耶鲁 - 达尔斯计划。潜在的研究项目：多个研究项目已准备好进行学者培训，可以在我们分配的时间范围内完成，例如使用国家大型数据集（例如VA老化队列（HIV）；危险因素，预防和治疗处方药滥用，基于办公室的阿片类药物依赖性治疗丁丙诺啡，系统评价和荟萃分析，为药物滥用，成瘾和HIV患者（包括处方药滥用）的患者创建具有成本效益的评估模型；在识别和治疗干预措施和结果中对性别和种族/种族差异的调查；评估特殊人群的筛查和治疗启动（即青少年，退伍军人，被监禁，艾滋病毒）；比较提供者和其他创新技术的筛查模型，简短的干预和转诊（SBIRT）交付的比较；具有急性和慢性医学复杂性的通用医学实践中SBIRT科学的有效性和实施。