IDeA National Resource for Quantitative Proteomics

IDeA 国家定量蛋白质组学资源

• 批准号: 10025463
• 负责人: Michael T Kinter
• 金额: $ 294万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-20 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10025463
• 关键词: Administrative Supplement; Animal Model; Arkansas; Award; Bioinformatics; Biomedical Research; Computer software; Computers and Advanced Instrumentation; Core Facility; Country; Data; Data Analyses; Development; Disease; Educational workshop; Experimental Designs; Face; Faculty; Fees; Funding; Generations; Goals; Grant; Human Resources; Infrastructure; Malignant Neoplasms; Mission; Modeling; National Institute of General Medical Sciences; Oklahoma; Peer Review; Pilot Projects; Positioning Attribute; Principal Investigator; Proteomics; Protocols documentation; Publications; Puerto Rico; Research; Research Personnel; Research Support; Resources; Sampling; Services; Students; Training; Translational Research; United States; United States National Institutes of Health; base; bioinformatics infrastructure; bioinformatics resource; cost; fundamental research; human disease; instrument; instrumentation; interest; mass spectrometer; online resource; operation; outreach; programs; response; service providers; symposium; user-friendly; voucher

ABSTRACT Through PAR-19-301, NIGMS seeks to support mission relevant resources that will have the economy of scale to provide increased access to state-of-the-art services for a substantial regional or national user base. In response, we are applying for NIGMS National Resource support for the IDeA National Resource for Quantitative Proteomics. This resource was created in 2016 using NIGMS-funding from the IDeA (Institutional Development Award) Program that supports research in 23 states and Puerto Rico that have historically received lower levels of NIH funding. The IDeA National Resource for Quantitative Proteomics was created by regional consolidation of instrumentation, proteomics expertise, and associated bioinformatics resources across Arkansas and Oklahoma. The resource was created because IDeA investigators across the United States can face specific challenges for accessing cutting-edge proteomics resources and bioinformatics expertise for data interpretation. These challenges include the cost of rapidly advancing instrumentation, availability of the personnel expertise those instruments demand, and access to bioinformaticians trained in proteomics. Arkansas and Oklahoma were positioned to unify their respective infrastructures to fill these resource gaps and provide a comprehensive solution for quantitative proteomics to the IDeA network. Our resource has had three years to become fully established and reach economy of scale. We have served a diverse set of IDeA investigators for their NIGMS relevant research, ranging from studies on model organisms to diseases such as cancer. The goal of this proposal is to transition the IDeA National Resource for Quantitative Proteomics to a NIGMS National Resource in order to expand our ability to serve the quantitative proteomics needs of the IDeA network. We will continue to provide user-friendly services for state-of-the-art, quantitative proteomics that will guide the user from service request to sophisticated bioinformatics analysis to delivery of publication ready data. This resource will continue to support the biomedical research mission of NIGMS and NIH for both fundamental and translational research focused on human diseases including cancer. We will use the following Specific Aims to accomplish our goal: 1) Provide state-of-the-art quantitative proteomics services to the IDeA network, 2) Provide outreach opportunities for quantitative proteomics to the IDeA network, and 3) Provide educational opportunities for quantitative proteomics to the IDeA network.

抽象的 通过Par-19-301，Nigms试图支持与任务相关的资源，这些资源将拥有经济 规模可为大量的区域或国家用户群提供增加获得最新服务的访问。在 回应，我们正在申请NIGMS国家资源支持国家资源的定量资源 蛋白质组学。该资源是在2016年创建的，它是利用该想法的Nigms资助（机构发展 奖）计划，该计划支持23个州和波多黎各的研究，这些研究历来较低 NIH资金。定量蛋白质组学的国家资源是通过区域合并创建的 仪器，蛋白质组学专业知识以及阿肯色州和 俄克拉荷马州。创建资源是因为美国各地的想法调查人员可以面对特定 获取尖端蛋白质组学资源和生物信息学专业知识的挑战。 这些挑战包括快速推进工具的成本，人员专业知识的可用性 这些工具要求，并与接受蛋白质组学培训的生物信息学家使用。阿肯色州和俄克拉荷马州是 位置统一各自的基础设施以填补这些资源空白并提供全面的资源差距 定量蛋白质组学的解决方案。我们的资源已有三年的时间 建立并达到规模经济。我们为他们的裸体提供了一套不同的想法调查员 相关研究，从模型生物的研究到癌症等疾病。目标的目标 提案是将定量蛋白质组学的国家资源转变为NIGMS国家资源 为了扩大我们满足想法网络定量蛋白质组学需求的能力。我们将继续 为最先进的定量蛋白质组学提供用户友好的服务，以指导用户从服务 请求复杂的生物信息学分析以提供出版物准备就绪数据。此资源将继续 支持Nigms和NIH的生物医学研究使命，既有基础研究和转化研究 专注于包括癌症在内的人类疾病。我们将使用以下特定目标来实现我们的目标：1） 为Idea网络提供最先进的定量蛋白质组学服务，2）提供外展机会 对于定量蛋白质组学到IDEA网络，3）为定量提供教育机会 蛋白质组学到想法网络。