Kansas Center for Metabolism and Obesity REsearch (KC-MORE) - Cells, Tissues, Bioanalysis and Biostatistics Core

堪萨斯代谢和肥胖研究中心 (KC-MORE) - 细胞、组织、生物分析和生物统计学核心

基本信息

批准号：
10598036
负责人：
Udayan Apte
金额：
$ 29.71万
依托单位：
UNIVERSITY OF KANSAS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-04-01 至 2027-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10598036
关键词：
Address Adipose tissue Animal Experiments Animal Model Arkansas Award Basic Science Big Data Bioinformatics Biological Assay Biomedical Research Biometry Biostatistics Core Blood Cell Culture Techniques Cells Cellular Structures Centers of Research Excellence Charge Clinical Collaborations Communities Computing Methodologies Confusion Core Facility Custom Data Collection Data Set Dedications Development Disease Experimental Models Face Flow Cytometry Funding Genomics Goals Grant Human In Vitro Infrastructure Institution Institutional Review Boards Investigation Kansas Liver Logistics Medical Medical center Metabolic Metabolic Diseases Metabolism Methodology Methods Muscle Nuts Obesity Obesity associated disease Organ Pathogenesis Patients Plasma Process Proteomics Research Research Personnel Research Project Grants Research Training Resources Rodent Sampling Science Scientist Serum Services Technical Expertise Techniques Technology Testing Tissue Banks Tissue Sample Tissues Training Translational Research United States National Institutes of Health Universities biobank design disease mechanisms study energy balance high throughput screening metabolomics multidimensional data patient population population based precision medicine skills transcriptomics translational pipeline

项目摘要

CELLS, TISSUES, BIOANALYSIS AND BIOSTATISTICS CORE: PROJECT SUMMARY Adding a translational component to confirm ideas generated using in vitro and animal models is a vital part of biomedical research. This is especially critical for a multi-organ disease like obesity. The most common path followed by basic scientists is to obtain human samples and perform bioanalytical tests confirming their findings obtained from experimental models. But this is easier said than done. Researchers face many challenges in bridging this translational gap including confusing regulatory paperwork, lack of willing clinical collaborators, lack of infrastructure to obtain and store patient samples, and much more. The Cells, Tissues, Bioanalysis and Biostatistics (CTBB) core is designed to address this very issue. The CTBB core will be a “soup to nuts” solution where the entire pipeline of translational research will be made efficient and easy to use for basic science researchers who are part of Kansas Center for Metabolism and Obesity REsearch (KC-MORE) and beyond. The CTBB core has three components. The first is the Cells and Tissues Biorepository, which will develop collaborations with clinicians willing to collect samples after obtaining necessary IRB permissions, and collect, store, and dispense clinical samples to basic scientists, supported by clinical coordinator. The second component is Bioanalytical services, where a trained research technician will be available to provide technical help to develop and perform specific bioanalytical assays. Further, we will function as liaisons between several existing institutional and regional NIH-funded core facilities and the COBRE investigators. These include Genomics core and Flow Cytometry core facilities at the University of Kansas Medical Center (KUMC) and IDEA National Resource for Quantitative Proteomics at University of Arkansas for Medical Sciences. The third component of the CTBB core is focused on biostatistics and bioinformatics expertise. For this, the CTBB core will collaborate with the Quantitative Omics core, which is part of Kansas Institute for Precision Medicine COBRE at KUMC. The CTBB core will partly support additional statisticians which will provide biostatistics and bioinformatics expertise to KC-MORE researchers. Taken together, the CTBB core will generate an efficient, comprehensive translational research pipeline, which will provide one stop solution for basic scientists to achieve translational research goals.

细胞、组织、生物分析和生物统计学核心：项目摘要添加翻译组件来确认使用体外和动物模型产生的想法是重要的一部分生物医学研究对于肥胖等多器官疾病尤其重要。接下来的基础科学家是获取人体样本并进行生物分析测试以证实他们的发现但这说起来容易做起来难。弥合这种转化差距，包括令人困惑的监管文书工作、缺乏愿意的临床合作者、缺乏获取和存储患者样本等的基础设施。生物统计学 (CTBB) 核心旨在解决这个问题。CTBB 核心将是一个“全面”的解决方案。整个转化研究流程将变得高效且易于用于基础科学堪萨斯代谢和肥胖研究中心 (KC-MORE) 及其他机构的研究人员。 CTBB 核心由三个组成部分组成，第一个是将开发的细胞和组织生物库。与愿意在获得必要的 IRB 许可后收集样本的牧师合作，并收集、在临床协调员的支持下，存储临床样本并将其分发给基础科学家。是生物分析服务，训练有素的研究技术人员将提供技术帮助以开发此外，我们将充当几个现有的联络人。 NIH 资助的机构和地区核心设施以及 COBRE 研究人员，其中包括基因组学核心。堪萨斯大学医学中心 (KUMC) 和 IDEA National 的流式细胞术核心设施阿肯色大学医学科学的定量蛋白质组学资源。 CTBB 核心专注于生物统计学和生物信息学专业知识为此，CTBB 核心将进行合作。定量组学核心是 KUMC 堪萨斯精准医学 COBRE 研究所的一部分。 CTBB 核心将部分支持额外的统计学家，提供生物统计学和生物信息学专业知识对于 KC-MORE 研究人员来说，CTBB 核心将产生一个高效、全面的转化。研究管道，将为基础科学家实现转化研究目标提供一站式解决方案。