IDeA National Resource for Quantitative Proteomics Supplement

IDeA 国家定量蛋白质组学补充资源

基本信息

批准号：
10796571
负责人：
Michael T Kinter
金额：
$ 24.81万
依托单位：
UNIV OF ARKANSAS FOR MED SCIS
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-20 至 2025-05-31
项目状态：
未结题

项目摘要

ABSTRACT Through PAR-19-301, NIGMS seeks to support mission relevant resources that will have the economy of scale to provide increased access to state-of-the-art services for a substantial regional or national user base. In response, we are applying for NIGMS National Resource support for the IDeA National Resource for Quantitative Proteomics. This resource was created in 2016 using NIGMS-funding from the IDeA (Institutional Development Award) Program that supports research in 23 states and Puerto Rico that have historically received lower levels of NIH funding. The IDeA National Resource for Quantitative Proteomics was created by regional consolidation of instrumentation, proteomics expertise, and associated bioinformatics resources across Arkansas and Oklahoma. The resource was created because IDeA investigators across the United States can face specific challenges for accessing cutting-edge proteomics resources and bioinformatics expertise for data interpretation. These challenges include the cost of rapidly advancing instrumentation, availability of the personnel expertise those instruments demand, and access to bioinformaticians trained in proteomics. Arkansas and Oklahoma were positioned to unify their respective infrastructures to fill these resource gaps and provide a comprehensive solution for quantitative proteomics to the IDeA network. Our resource has had three years to become fully established and reach economy of scale. We have served a diverse set of IDeA investigators for their NIGMS relevant research, ranging from studies on model organisms to diseases such as cancer. The goal of this proposal is to transition the IDeA National Resource for Quantitative Proteomics to a NIGMS National Resource in order to expand our ability to serve the quantitative proteomics needs of the IDeA network. We will continue to provide user-friendly services for state-of-the-art, quantitative proteomics that will guide the user from service request to sophisticated bioinformatics analysis to delivery of publication ready data. This resource will continue to support the biomedical research mission of NIGMS and NIH for both fundamental and translational research focused on human diseases including cancer. We will use the following Specific Aims to accomplish our goal: 1) Provide state-of-the-art quantitative proteomics services to the IDeA network, 2) Provide outreach opportunities for quantitative proteomics to the IDeA network, and 3) Provide educational opportunities for quantitative proteomics to the IDeA network.

抽象的通过 PAR-19-301，NIGMS 寻求支持任务相关资源，这些资源将具有经济性规模，为大量区域或国家用户群提供更多最先进的服务。在响应，我们正在申请 NIGMS 国家资源支持 IDeA 国家定量资源蛋白质组学。该资源于 2016 年使用 IDeA（机构发展奖）支持历史上获得较低水平的 23 个州和波多黎各研究的计划 NIH 的资助。 IDeA 国家定量蛋白质组学资源是通过区域整合创建的阿肯色州和阿肯色州的仪器、蛋白质组学专业知识和相关生物信息学资源俄克拉荷马州。创建该资源是因为美国各地的 IDeA 调查员可能面临特定的问题获取尖端蛋白质组学资源和生物信息学专业知识以进行数据解释的挑战。这些挑战包括快速发展仪器的成本、人员专业知识的可用性这些工具需要接受过蛋白质组学培训的生物信息学家。阿肯色州和俄克拉荷马州分别是旨在统一各自的基础设施，以填补这些资源缺口并提供全面的 IDeA 网络的定量蛋白质组学解决方案。我们的资源已经用了三年的时间才完全建立并达到规模经济。我们为不同的 IDeA 研究人员提供了 NIGMS 服务相关研究，从模式生物研究到癌症等疾病。此举的目标提案是将 IDeA 定量蛋白质组学国家资源转变为 NIGMS 国家资源为了扩大我们满足 IDeA 网络定量蛋白质组学需求的能力。我们将继续为最先进的定量蛋白质组学提供用户友好的服务，指导用户完成服务要求进行复杂的生物信息学分析以提供可发表的数据。这个资源会继续支持 NIGMS 和 NIH 的生物医学研究任务，包括基础研究和转化研究重点关注包括癌症在内的人类疾病。我们将使用以下具体目标来实现我们的目标：1) 为 IDeA 网络提供最先进的定量蛋白质组学服务，2) 提供推广机会用于 IDeA 网络的定量蛋白质组学，以及 3) 提供定量蛋白质组学的教育机会 IDeA 网络的蛋白质组学。

项目成果

期刊论文数量（26）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

SILAC Phosphoproteomics Reveals Unique Signaling Circuits in CAR-T Cells and the Inhibition of B Cell-Activating Phosphorylation in Target Cells.

DOI：
10.1021/acs.jproteome.1c00735
发表时间：
2022-02-04
期刊：
Journal of proteome research
影响因子：
4.4
作者：
Griffith AA;Callahan KP;King NG;Xiao Q;Su X;Salomon AR
通讯作者：
Salomon AR

Lipid environment modulates processivity and kinetics of a presenilin homolog acting on multiple substrates in vitro.

DOI：
10.1016/j.jbc.2023.105401
发表时间：
2023-12
期刊：
JOURNAL OF BIOLOGICAL CHEMISTRY
影响因子：
4.8
作者：
Wu, Yuqi;Thomas, Gwendell M.;Thomsen, Max;Bahri, Sara;Lieberman, Raquel L.
通讯作者：
Lieberman, Raquel L.

Neoplastic signatures: Comparative proteomics of canine hepatobiliary neuroendocrine tumors to normal niche tissue.

DOI：
10.1371/journal.pone.0280928
发表时间：
2023
期刊：
PLOS ONE
影响因子：
3.7
作者：
Batts, Tifini L.;Sasaki, Emi W.;Miller, Mayzie;Sparago, Joshua;Bauer, Rudy W.;Paulsen, Daniel D.;Boudreaux, Bonnie N.;Liu, Chin-Chi;Byrum, Stephanie D.;Johnston, Andrea N.
通讯作者：
Johnston, Andrea N.

Antiviral responses in a Jamaican fruit bat intestinal organoid model of SARS-CoV-2 infection.

DOI：
10.1038/s41467-023-42610-x
发表时间：
2023-10-28
期刊：
NATURE COMMUNICATIONS
影响因子：
16.6
作者：
Hashimi, Marziah;Sebrell, T. Andrew;Hedges, Jodi F.;Snyder, Deann;Lyon, Katrina N.;Byrum, Stephanie D.;Mackintosh, Samuel G.;Crowley, Dan;Cherne, Michelle D.;Skwarchuk, David;Robison, Amanda;Sidar, Barkan;Kunze, Anja;Loveday, Emma K.;Taylor, Matthew P.;Chang, Connie B.;Wilking, James N.;Walk, Seth T.;Schountz, Tony;Jutila, Mark A.;Bimczok, Diane
通讯作者：
Bimczok, Diane

Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer.