IMAGING THE DEPRESSION/DEMENTIA INTERACE

想象抑郁症/痴呆症的相互作用

• 批准号: 7627692
• 负责人: Carolyn C Meltzer
• 金额: $ 1万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7627692
• 关键词: Age; Alzheimer' s Disease; Antidepressive Agents; Award; Binding; Clinical; Complement; Computer Retrieval of Information on Scientific Projects Database; Dementia; Development; Discipline of Nuclear Medicine; Doctor of Medicine; Doctor of Philosophy; Elderly; Funding; Future; Gender; Genetic; Grant; Hippocampus (Brain); Image; Imaging Techniques; Impaired cognition; Institution; K-Series Research Career Programs; Link; Major Depressive Disorder; Mental Depression; Mental disorders; Mentors; Midcareer Investigator Award in Patient-Oriented Research; Modeling; Persons; Pharmacotherapy; Physicians; Play; Positron-Emission Tomography; Prefrontal Cortex; Purpose; Research; Research Personnel; Resources; Risk; Role; Serotonin; Serotonin Receptor 5-HT1A; Site; Source; Support of Research; System; Testing; Time; Training; United States National Institutes of Health; Work; aging brain; career; design; experience; geriatric depression; in vivo; member; neuroimaging; older patient; patient oriented; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This revised application for a Midcareer Investigator Award in Patient-Oriented Research (K24) seeks to provide the candidate, a neuroradiologist and nuclear medicine physician with existing extensive positron emission tomography (PET) imaging experience, with support for focused research and additional training in mechanisms underlying the interface between late-life depression and dementia, and for mentoring activities. This award will be applied to an NIMH-funded R01 (MH59945) investigating central serotonergic function in late-life depression with PET. Depression in late life carries an increased risk of dementia and brittle response to treatment. The R01-supported Research Plan entails quantitative imaging of two important markers strongly implicated in depression and mechanisms of antidepressant pharmacotherapy: the 5-HT1A receptor and the 5-HT transporter, PET imaging of these two sites in untreated elderly patients with major depression and age, gender-matched controls will test a model of late-life depression, including our hypotheses that 5-HT1A binding in the prefrontal cortex will be predictive of treatment responsivity and hippocampal 5-HT1A binding will correlate with baseline cognitive impairment and, more importantly, dementia risk. Career Development will incorporate training in basic mechanisms and clinical aspects of Alzheimer's disease. Since genetic studies will likely play a substantial role in future investigative efforts aimed at identifying persons at high risk for developing dementia and assessing antidepressant treatment responsivity, the candidate seeks training that will enable her to be an educated member of a multi-disciplinary research team using both genetic and a variety of in vivo imaging markers to study dementia risk and its link to late-life depression. These dements are complemented by a Mentoring Plan supportive of the candidate's further development as a mentor of both M.D. and Ph.D. trainees in the conduct of patient-oriented neuroimaging research. This K24 application extends the PI's NIMH-supported level I K-award (K07) work in PET imaging of the 5-HT system in late-life mental disorders. The purpose of the current proposal is to provide the candidate with 25% protected time to: 1) expand her efforts in mentoring junior clinical neuroscientists in neuroimaging, and 2) to acquire advanced training that will meet the challenges of designing and implementing future large-scale investigative efforts to apply specialized PET imaging techniques to studies of brain aging.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 此次修订后的以患者为导向的研究中职业生涯研究者奖 (K24) 申请旨在为候选人、神经放射科医生和核医学医师提供现有的广泛正电子发射断层扫描 (PET) 成像经验，并支持重点研究和机制方面的额外培训晚年抑郁症和痴呆症之间的相互作用的基础，并用于指导活动。该奖项将应用于 NIMH 资助的 R01 (MH59945)，该项目旨在通过 PET 研究晚年抑郁症的中枢血清素功能。晚年的抑郁症会增加患痴呆症的风险和对治疗的脆弱反应。 R01 支持的研究计划需要对与抑郁症和抗抑郁药物治疗机制密切相关的两个重要标志物进行定量成像：5-HT1A 受体和 5-HT 转运蛋白，对未经治疗的重度抑郁症老年患者和年龄的这两个部位进行 PET 成像，性别匹配的对照将测试晚年抑郁症模型，包括我们的假设，即前额皮质中的 5-HT1A 结合将预测治疗反应性和海马5-HT1A 结合与基线认知障碍相关，更重要的是，与痴呆风险相关。职业发展将包括阿尔茨海默病基本机制和临床方面的培训。由于基因研究可能会在未来的调查工作中发挥重要作用，这些调查工作旨在识别罹患痴呆症的高风险人群并评估抗抑郁药物治疗的反应性，因此候选人寻求培训，使她能够成为多学科研究团队中受过教育的成员，使用遗传和各种体内成像标记物来研究痴呆风险及其与晚年抑郁症的联系。这些要素还得到了指导计划的补充，该计划支持候选人作为医学博士和博士导师的进一步发展。受训人员进行以患者为导向的神经影像研究。该 K24 应用扩展了 PI 在 5-HT 系统 PET 成像治疗晚年精神障碍方面的 NIMH 支持的 I 级 K 奖 (K07) 工作。当前提案的目的是为候选人提供 25% 的受保护时间，以：1）扩大其在神经影像学领域指导初级临床神经科学家的努力，2）获得高级培训，以应对设计和实施未来大型项目的挑战。扩大研究力度，将专门的 PET 成像技术应用于脑衰老研究。