ALZHEIMER'S DISEASE RESEARCH CENTER IMAGING CORE SUPPLEMENT

阿尔茨海默病研究中心影像核心补充品

• 批准号: 7724494
• 负责人: Carolyn C Meltzer
• 金额: $ 1.03万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7724494
• 关键词: Address; Advisory Committees; Aging; Alzheimer' s Disease; Arts; Brain; Communities; Computer Retrieval of Information on Scientific Projects Database; Data; Dementia; Diagnostic; Disease; Elderly; Functional Imaging; Functional Magnetic Resonance Imaging; Funding; Goals; Grant; Image; Institution; Invasive; Magnetic Resonance Imaging; Patients; Pharmacotherapy; Positron; Research; Research Infrastructure; Research Personnel; Resources; Source; Subgroup; Technology; United States National Institutes of Health; Universities; aging brain; base; concept; design; improved; in vivo; interest; mild neurocognitive impairment; neuroimaging; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. An imperative for developing non-invasive tools with early diagnostic capability has resulted from the recent availability of effective forms of pharmacotherapy for Alzheimer¿s disease (AD). The Neuroimaging Core of the University of Pittsburgh Alzheimer's Disease Research Center (ADRC) supports structural and functional magnetic resonance imaging (MRI) in research patients and provides the infrastructure for developing state-of-the-art structural and functional MRI and positron emission tomographic (PET) imaging in aging and dementia. The combined input from the reviewers of our ADRC Competing Renewal and our External Advisory Committee has supported our goal of widely standardizing the MRI data collected on ADRC subjects, as well as controls, in order to develop an "in vivo brain bank". This concept would serve as a highly valuable resource for the large community of investigators of aging and dementia at the University of Pittsburgh. Therefore, we are requesting additional funding support of structural and functional imaging of well-characterized healthy elders and specific patient subgroups of interest (e.g. mild cognitive impairment) to specifically address the needs of ADRC investigators. These data will also serve as the basis for implementing and disseminating a set of methodologic tools designed to improve the interpretation of imaging studies of the aging brain. This application for a competititve supplement is in support of the overarching aim of the ADRC Neuroimaging core to continue to develop and distribute technology for acquiring and interpreting structural and functional image data in support of AD research.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以出现在其他 CRISP 条目中 列出的机构是。 中心，不一定是研究者的机构。 由于最近出现了针对阿尔茨海默病的有效药物疗法，因此迫切需要开发具有早期诊断能力的非侵入性工具。匹兹堡大学阿尔茨海默病研究中心 (ADRC) 的神经影像核心支持研究患者的结构和功能磁共振成像 (MRI)，并为开发最先进的结构和功能提供基础设施。衰老和痴呆症的 MRI 和正电子发射断层扫描 (PET) 成像 ADRC 竞争更新评审员和外部咨询委员会的综合意见支持了我们广泛标准化 ADRC 受试者收集的 MRI 数据的目标。以及对照，以开发“体内脑库”，这一概念将为匹兹堡大学的老龄化和痴呆症研究人员提供非常宝贵的资源。因此，我们请求额外的资金支持。对特征明确的健康老年人和感兴趣的特定患者亚组（例如轻度认知障碍）进行结构和功能成像，以专门满足 ADRC 研究人员的需求。这些数据也将作为实施和传播一套旨在实现的方法工具的基础。改善影像学研究的解释这种有效补充的应用程序支持 ADRC 神经影像核心的总体目标，即继续开发和分发用于获取和解释结构和功能图像数据的技术，以支持 AD 研究。