Developmental Projects

发展项目

• 批准号: 7490251
• 负责人: Carolyn C Meltzer
• 金额: $ 7.4万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7490251
• 关键词: Area; Biohazardous Substance; Biomedical Engineering; Brain Neoplasms; Breast Cancer Early Detection; Cancer Patient; Certification; Data; Detection; Development; Dissection; Electronics; Faculty; Fostering; Funding; Future; Grant; Growth; IACUC; Image; Institutes; Interferon-alpha; Investments; Joints; K-Series Research Career Programs; Lead; Macaca mulatta; Magnetic Resonance Imaging; Malignant Neoplasms; Malignant neoplasm of lung; Malignant neoplasm of pancreas; Methodology; Methods; Mission; Modeling; Molecular; Monitor; Notification; Numbers; Optics; PK 11195; Pilot Projects; Preparation; Radiation; Radiology Specialty; Rattus; Research; Research Ethics Committees; Research Personnel; Research Project Grants; Resources; Safety; Scientist; Source; TNFRSF5 gene; Techniques; Tumor Suppressor Proteins; USA Georgia; Universities; Vision; Week; Western Asia Georgia; base; career; cone-beam computed tomography; molecular imaging; molecular/cellular imaging; nanoscale; programs; radiotracer; receptor; skills; tumor

An important component of the Emory Molecular and Translational Imaging Center (EMTIC) is the establishment of a strong pilot program to foster the continued growth of cancer-targeted molecular imaging research at Emory by bringing new investigators into EMTIC. Through the availability of Developmental Funds for Pilot Projects supported at the level of $35,000/year per pilot project, EMTIC will foster a steady source of new ideas, applications areas for new methodologies developed within the Cores, and opportunities for both trainees and established scientists to acquire preliminary data in the quantitative molecular imaging arena on which to base competitive future R01 proposals. Five outstanding pilot projects were selected following the solicitation of pilot proposals from all faculty affiliated with the Winship Cancer Institute (WCI) and those in the Departments of Radiology at Emory University and/or Biomedical Engineering at Georgia Tech. The Pilot Projects were chosen using the following review criteria: 1) scientific strengths, including likelihood to lead to R01 funding, 2} "fit" with the developing EMTIC vision, 3) was it potentially translational with a benefit to cancer patients, and 4) integration with institutional linkages and WCI programs. The Pilot Projects include: Pilot Project 1. Receptor-targeted Radiotracers for Detection of Pancreatic Cancer; Pilot Project 2. Optical Dissection of a Lung Cancer Tumor Suppressor; Pilot Project 3. Imaging Tumor HIF-1 Activity in a Rat Orthotopic Brain Tumor Model by MRI; Pilot Project 4, Identifying IFN-alpha-lnduced Microglial Activation Using C-11 PK11195 versus F-18 PK11195 in Rhesus Monkeys; and Pilot Project 5. Targeted "Triggerable" Nanoscale Contrast Enhanced Cone Beam Computed Tomography (CBCT) for Early Breast Cancer Detection. The Pilot Projects are highly integrated with both EMTIC Research Projects and Cores to benefit and contribute to the overall mission of this center grant.

埃默里分子和转化成像中心 (EMTIC) 的一个重要组成部分是 建立强有力的试点计划，促进癌症靶向分子药物的持续增长 通过将新研究人员引入 EMTIC，在埃默里进行影像研究。通过可用性 试点项目发展基金的支持金额为每个试点项目每年 35,000 美元， EMTIC 将为新开发的方法论培育新思想和应用领域的稳定来源 核心内，以及实习生和知名科学家获得初步知识的机会 定量分子成像领域的数据是未来具有竞争力的 R01 提案的基础。 经过向各地征集试点建议，评选出5个优秀试点项目 温希普癌症研究所 (WCI) 附属人员和放射科人员 埃默里大学和/或佐治亚理工学院的生物医学工程。 试点项目的选择采用以下审查标准：1) 科学优势，包括 获得 R01 资金的可能性，2}“符合”正在发展的 EMTIC 愿​​景，3) 是否有潜力 转化为癌症患者带来益处，4) 与机构联系和 WCI 整合 程序。试点项目包括： 试点项目 1. 用于检测的受体靶向放射性示踪剂 胰腺癌;试点项目 2. 肺癌肿瘤抑制因子的光学解剖；飞行员 项目3.通过MRI对大鼠原位脑肿瘤模型中的肿瘤HIF-1活性进行成像；试点项目 4，使用 C-11 PK11195 与 F-18 PK11195 鉴定 IFN-α 诱导的小胶质细胞活化 恒河猴；和试点项目 5. 有针对性的“可触发”纳米级对比度增强锥体 用于早期乳腺癌检测的光束计算机断层扫描 (CBCT)。试点项目是 与 EMTIC 研究项目和核心高度集成，为 该中心赠款的总体使命。