Emory-Georgia Clean Air Research & Education (CARE) Program

埃默里-佐治亚州清洁空气研究

• 批准号: 10017980
• 负责人: Carla J Berg
• 金额: $ 24.14万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-13 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10017980
• 关键词: Address; Adult; Affect; Air; Air Pollution; Applied Research; Centers for Disease Control and Prevention (U.S.); Cessation of life; Child; Collaborations; Country; Education; Environment; Environmental Exposure; Environmental Hazards; Environmental Health; Funding; Goals; Grant; Health; Indoor Air Pollution; Infrastructure; Institution; Joints; Medical; Mentors; Mentorship; Molecular; Morbidity - disease rate; National Institute of Environmental Health Sciences; Policies; Pollution; Population; Positioning Attribute; Public Health; Reporting; Research; Research Training; Time; Training; Training Programs; Universities; Western Asia Georgia; Woman; ambient air pollution; attributable mortality; burden of illness; education research; environmental tobacco smoke; environmental tobacco smoke exposure; global health; indexing; knowledge translation; low and middle-income countries; men; mortality; programs; public health priorities; ranpirnase; research data dissemination; smoke-free policy; smoking prevalence; statistics; training opportunity

SUMMARY/ABSTRACT Globally, 7 million deaths are attributable to the joint effects of indoor and ambient air pollution annually, with ~94% occurring in low- and middle-income countries (LMICs). In addition, secondhand smoke (SHS) is a major global health problem, causing ~600,000 deaths (1% of mortality) annually, with women and children being disproportionately affected by SHS. LMICs are also disproportionately impacted by SHS and related morbidity and mortality. The Republic of Georgia (GE) is notably impacted by air pollution and SHS. Adverse environmental exposures cause 21% of disease burden and 25% of deaths, including 30% of disease burden and 14% of deaths among children. Moreover, GE’s mortality index attributed to ambient and indoor air pollution is the 3rd highest in the world. Additionally, the smoking prevalence in GE is 58% in men (6th highest in the world) and 6% in women, implying significant impact of SHS in GE. Indeed, 42% of GE adults report daily SHS exposure. Underscoring the impact of these statistics, GE’s 2017-2021 National Environment and Health Action Plan indicates that addressing air pollution is among the most prominent public health priorities in GE. However, there is limited in-country capacity to conduct research regarding the impact of such environmental hazards on health. This application, the Emory-Georgia Clean Air Research and Education (EG-CARE) program, coincides with increased prioritization of research and policy to reduce air pollution and address NCDs in GE, and represents a uniquely strategic collaboration among Emory University, the GE National Center for Disease Control and Public Health (NCDC), the GE National Environmental Agency (NEA), and Tbilisi State Medical University (TSMU). Various existing collaborations and ongoing efforts will be leveraged, including Fogarty-funded grants to promote smoke-free air policies in GE (an R01) and to enhance TB research capacity in GE (a D43), as well as an NIEHS-funded center grant called HERCULES (a P30) and an NIEHS-funded T32 training program at Emory. Key leaders of these efforts and across these institutions will collaborate to implement this training program, with the long-term goal of enhancing capacity in GE to conduct research related to NCDs and environmental health (EH) and ultimately inform policy and practice to reduce NCDs. The overall objective of this application is to develop and implement a training program involving training, mentorship, and applied research opportunities to ultimately reach the long-term goal. Thematically, EG-CARE will focus on the intersection between NCDs and EH, particularly air pollution, and aim to: 1) enhance formal NCD and EH training opportunities and institutional infrastructure to support ongoing research training; 2) provide mentored NCD- and EH- related research opportunities spanning from the molecular to the population level, with a particular focus on air quality and pollution, to candidates with outstanding potential; and 3) emphasize research dissemination and knowledge translation to inform policy and practice. Leveraging the aforementioned ongoing efforts, this proposal addresses a timely, high-priority public health concern in GE, underscoring its potential impact. The program team is uniquely positioned to address these aims and enhance research capacity related to NCDs and EH in the next 5 years and in the long term.

摘要/摘要 在全球范围内，700万人死亡归因于室内和环境空气污染的共同影响，约为94％ 发生在低收入和中等收入国家（LMIC）。此外，二手烟（SHS）是全球主要的健康 问题，每年造成约600,000人死亡（占死亡率的1％），妇女和儿童受到不成比例的影响 由shs。 LMIC也受到SHS以及相关的发病率和死亡率的不成比例影响。共和国 佐治亚州（GE）受空气污染和SHS的影响。不利的环境暴露会导致21％的疾病 负担和25％的死亡，包括30％的疾病烧伤和14％的儿童死亡。而且，GE的死亡率 归因于环境和室内空气污染的索引是世界排名第三。此外，吸烟的患病率 GE在男性中为58％（世界排名第六），女性为6％，这意味着SHS在GE中的影响很大。确实，有42％ GE成人报告每日SHS暴露。强调了这些统计数据的影响，GE的2017 - 2021年国家环境 健康行动计划表明，解决空气污染是GE中最杰出的公共卫生重点之一。 但是，国内能力有限地进行有关此类环境危害的影响的研究 健康。该应用程序是Emory-Georgia清洁空气研究与教育（EG-CARE）计划，与 提高了研究和政策的优先级，以减少空气污染并解决GE中的NCD，并代表一个独特的 Emory大学，GE国家疾病控制与公共卫生中心（NCDC）之间的战略合作， GE国家环境局（NEA）和第比利斯州立医科大学（TSMU）。各种现有 合作和持续的努力将被杠杆付出 在GE（R01）中，并提高GE中的结核病研究能力（A D43），以及NIEHS资助的中心赠款 Hercules（A P30）和Emory的NIEHS资助的T32培训计划。这些努力以及这些努力的主要领导者 机构将合作实施该培训计划，其长期目标是提高GE的能力 进行与NCD和环境健康有关（EH）有关的研究，并最终为政策和实践提供依据 NCD。该应用程序的总体目的是制定和实施涉及培训的培训计划， 遗产和应用研究机会最终达到了长期目标。从主题上讲，例如护理将集中精力 在NCD与EH之间的交集，尤其是空气污染，目的是：1）增强正式的NCD和EH培训 机会和机构基础设施以支持正在进行的研究培训； 2）提供了指导的NCD和EH- 从分子到人口水平的相关研究机会，特别关注空气质量 和污染，给有杰出潜力的候选人； 3）强调研究传播和知识 翻译以告知政策和实践。该提案利用了持续的努力，及时解决了 GE中的高优先公共卫生关注，强调了其潜在影响。计划团队独特地定位 解决这些目标并增强与NCD和EH相关的研究能力，并在长远来看。