STRUCTURAL STUDIES OF NOVEL HOOKWORM VACCINE CANDIDATES

新型钩虫疫苗候选物的结构研究

• 批准号: 7601604
• 负责人: OLUWATOYIN Ajibola ASOJO
• 金额: $ 0.55万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7601604
• 关键词: AIDS/HIV problem; Adult; Affect; Antigens; Child; Complex; Computer Retrieval of Information on Scientific Projects Database; Disease; Drug Delivery Systems; Funding; Grant; Growth; Hemorrhage; Hookworm Infections; Hookworms; Human; Immune; Immune system; Infection; Institution; Iron deficiency anemia; Life; Life Cycle Stages; Malaria; Methods; Parasitic nematode; Process; Psyche structure; Quality of life; Research; Research Personnel; Resources; Soil; Source; Staging; Structure; Tuberculosis; United States National Institutes of Health; Vaccine Antigen; Vaccines; beamline; novel; novel therapeutics; programs; tool; vaccine development

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Human hookworm disease is a devastating disease and a major source of blood-loss and iron-deficiency anemia in the developing world. Human hookworm infection affects about one billion people, many of them children, leading to stunted physical growth, mental underdevelopment and reduced quality of life. This disease is caused by parasitic nematodes with a complex life cycle which includes a free-living stage. Hookworms are the most pathogenic soil-transmitted helminthes. Hookworms are also masters of disguise that upon infection produce antigens that facilitate the evasion and suppression of the host¿s immune system. Immune suppression by hookworms leads to easier infection by other diseases, including malaria, tuberculosis, and HIV/AIDS. Conventional methods of hookworm control and eradication have largely failed and there is a need to develop new therapeutics to combat this devastating disease. There are on-going efforts to develop new tools to control hookworm infection, including a hookworm vaccine development program (The Human Hookworm Vaccine Initiative, HHVI). The HHVI identified candidate vaccine antigens from the infective L3 as well as from the adult stage. We are in the process of crystallizing and solving the structures of some of these vaccine candidates. Beamline access will facilitate our ongoing structural studies of novel hookworm vaccines and drug targets.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以出现在其他 CRISP 条目中 列出的机构是。 对于中心来说，它不一定是研究者的机构。 人类钩虫病是一种毁灭性的疾病，是发展中国家失血和缺铁性贫血的主要根源。人类钩虫感染影响着大约十亿人，其中许多是儿童，导致身体发育迟缓、智力发育不全和素质下降。这种疾病是由具有复杂生命周期的寄生线虫引起的，钩虫是致病性最强的土壤传播的蠕虫，也是感染后产生的伪装大师。促进宿主逃避和抑制的抗原¿钩虫的免疫抑制导致更容易感染其他疾病，包括疟疾、结核病和艾滋病毒/艾滋病，传统的钩虫控制和根除方法基本上已经失败，因此需要开发新的疗法来对抗这种毁灭性疾病。人们正在努力开发控制钩虫感染的新工具，包括钩虫疫苗开发计划（人类钩虫疫苗计划，HHVI），HHVI 从感染性病原体中鉴定出候选疫苗抗原。 L3 以及成虫阶段。我们正在结晶和解决其中一些候选疫苗的结构，这将有助于我们正在进行的新型钩虫疫苗和药物靶标的结构研究。