No-Touch High Resolution Optical Coherence Elastography of the Cornea using a Heartbeat

使用心跳进行角膜非接触式高分辨率光学相干弹性成像

基本信息

批准号：
10705274
负责人：
Kirill V Larin
金额：
$ 55.74万
依托单位：
UNIVERSITY OF HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-30 至 2027-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10705274
关键词：
3-Dimensional Acceleration Achievement Adoption Agreement Air Algorithms Biomechanics Cataract Extraction Characteristics Clinic Clinical Collagen Connective Tissue Cornea Corneal Diseases Detection Development Diagnostic Diagnostic tests Discipline Disease Elasticity Eye Eye Development Eye diseases Frequencies Glaucoma Goals Health Human Iatrogenesis Image Intervention Journals Keratoconus Keratoplasty Knowledge Laser In Situ Keratomileusis Link Local Therapy Maps Measurement Measures Mechanics Methods Modeling Myopia Nature Office Visits Operative Surgical Procedures Optics Oryctolagus cuniculus Paper Pathologic Patients Performance Pharmacotherapy Phase Physiologic Intraocular Pressure Physiologic pulse Physiological Procedures Property Protocols documentation Reporting Resolution Retina Routine Diagnostic Tests Scanning Sclera Source Speed System Techniques Technology Testing Therapeutic Therapeutic Intervention Therapeutic procedure Tissue Transplantation Tissues Touch sensation Translations Visual System biomechanical test clinic ready clinical practice clinical translation corneal epithelial wound healing corneal surgery crosslink design disease diagnosis efficacy testing elastography improved improved outcome in vivo innovative technologies mechanical properties new technology next generation novel novel strategies personalized medicine research clinical testing response screening spatiotemporal submicron success translational applications translational potential wound healing

3-Dimensional Acceleration Achievement Adoption Agreement Air Algorithms Biomechanics Cataract Extraction Characteristics Clinic Clinical Collagen Connective Tissue Cornea Corneal Diseases Detection Development Diagnostic Diagnostic tests Discipline Disease Elasticity Eye Eye Development Eye diseases Frequencies Glaucoma Goals Health Human Iatrogenesis Image Intervention Journals Keratoconus Keratoplasty Knowledge Laser In Situ Keratomileusis Link Local Therapy Maps Measurement Measures Mechanics Methods Modeling Myopia Nature Office Visits Operative Surgical Procedures Optics Oryctolagus cuniculus Paper Pathologic Patients Performance Pharmacotherapy Phase Physiologic Intraocular Pressure Physiologic pulse Physiological Procedures Property Protocols documentation Reporting Resolution Retina Routine Diagnostic Tests Scanning Sclera Source Speed System Techniques Technology Testing Therapeutic Therapeutic Intervention Therapeutic procedure Tissue Transplantation Tissues Touch sensation Translations Visual System biomechanical test clinic ready clinical practice clinical translation corneal epithelial wound healing corneal surgery crosslink design disease diagnosis efficacy testing elastography improved improved outcome in vivo innovative technologies mechanical properties new technology next generation novel novel strategies personalized medicine research clinical testing response screening spatiotemporal submicron success translational applications translational potential wound healing

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项目摘要

PROJECT SUMMARY The mechanical properties of the cornea determine the structural characteristics of the ocular globe and may be altered in several devastating disease states, including axial elongation in myopia, pathological deformation in keratoconus, and iatrogenic keratoectasia following corneal refractive surgery. Accurate measurement of corneal biomechanics with high spatial resolution would not only influence our clinical interpretation of diagnostic tests, e.g., measuring intraocular pressure or assessing effects of drug therapies, but also predict the development of posterior eye diseases, such as glaucoma. Currently, there is no available reliable method to perform quantitative measurement of corneal elasticity in vivo and with high resolution. Here we propose a novel method for a “no- touch” assessment of corneal elastic properties. Such a technology, termed heart-beat optical coherence elastography (hbOCE), could revolutionize methods for routine corneal examination, bringing additional mechanical information and warrant rapid clinical adaptation. The project has four primary Specific Aims: Aim 1 is focused on the development of a hbOCE system capable of high-speed volumetric measurement of corneal deformation under small intrinsic IOP changes. Aim 2 will test the developed system in the eyes ex vivo. Aim 3 will test the system in eyes in vivo in rabbits. Aim 4 will perform in vivo human studies to refine measurement methods for broader clinical use. The proposed project will make fundamental advances in the understanding of corneal biomechanics through a novel approach with potentially impactful applications in other disciplines (e.g., corneal surgery, LASIK, corneal cross-linking, corneal transplants, personalized treatments). Most importantly, the proposed studies will accelerate the transition of ocular elastography into clinics, influence our selection and application of corneal surgical treatments, and will help us understand the structural consequences of corneal diseases and wound healing.

项目摘要角膜的机械性能决定了眼球的结构特性，可能是在几个毁灭性疾病状态中发生了改变，包括近视的轴向伸长，病理变形角膜屈光手术后的角膜结构和医源性角膜切开症。准确测量角膜具有高空间分辨率的生物力学不仅会影响我们对诊断测试的临床解释，还会影响例如，测量眼内压或评估药物疗法的作用，但也预测后眼疾病，例如青光眼。当前，没有可靠的可靠方法来执行定量在体内和高分辨率的角膜弹性测量。在这里，我们提出了一种新颖的方法，用于“ 触摸”角膜弹性特性的评估。这种技术称为心跳光学连贯性弹性图（HBOCE）可以彻底改变常规角膜检查的方法，带来其他机械信息和保证快速临床适应。该项目有四个主要的特定目标： AIM 1的重点是开发HBOCE系统，以高速体积测量在小固有的IOP变化下，角膜变形。 AIM 2将在眼睛的眼睛中测试开发的系统。 AIM 3将在兔子中的体内测试系统。 AIM 4将进行体内人类研究，以完善更广泛的临床用途的测量方法。拟议的项目将通过新方法在其他学科中具有潜在影响的应用（例如角膜手术，Lasik，角膜交联，角膜移植，个性化治疗）。最重要的是，拟议的研究将加速眼部弹性学向诊所的过渡，影响我们的角膜选择和应用手术治疗，将帮助我们了解角膜疾病和伤口的结构性后果康复。