Prenatal alcohol/cannabinoid co-exposures and fetal brain development

产前酒精/大麻素共同暴露与胎儿大脑发育

• 批准号: 10517743
• 负责人: Kirill V Larin
• 金额: $ 1.46万
• 依托单位: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10517743
• 关键词: Alcohol abuse; Alcohols; Angiography; Area; Award; Behavioral; Biological Assay; Biophysics; Blood Vessels; Blood flow; Brain; Cannabinoids; Cells; Cerebrovascular Circulation; Collaborations; Communication; Complement; Data Analyses; Development; Dose; Drug abuse; Embryo; Ensure; Ethanol; Experimental Designs; Exposure to; Female; Fluorescence; Goals; Growth; Health; Image; Imaging Techniques; Imaging technology; Laboratories; Light; Long-Term Effects; Mentors; Mentorship; Microscopy; Multimodal Imaging; Mus; National Institute on Alcohol Abuse and Alcoholism; Neonatal; Optical Coherence Tomography; Optics; Parents; Physiological; Physiology; Process; Protocols documentation; Publishing; Reporter; Research; Research Personnel; Research Project Grants; Stains; Tomatoes; Training; Ultrasonography; Writing; alcohol effect; alcohol exposure; alcohol research; angiogenesis; base; behavioral outcome; biomedical imaging; career; experimental study; fetal; fluorescence imaging; high resolution imaging; imaging approach; in utero; in vivo; male; multidisciplinary; nerve stem cell; offspring; optical imaging; parent grant; prenatal; research and development; response; skills; synthetic cannabinoid; tool; vasculogenesis

PROJECT SUMMARY This is an application in response to NIAAA Research Supplements to Promote Diversity in Health-Related Research. The candidate's research will be within the scope of the parent award: the utilization of optical noninvasive and high-resolution imaging technology to assess the effects of ethanol and cannabinoid exposure on fetal brain growth and analyze the changes in the vasculature supporting brain development. Complementing the approach described in the parent grant, the candidate will perform additional experiments of embryonic imaging using fluorescence and ultrasound imaging techniques for corroboration with the ongoing and already published Optical Coherence Tomography (OCT)-imaged results. The candidate's training plan includes the development of research, communication, and writing skills and extensive training in physiology and biophysics of alcohol and drug abuse. .

项目概要 这是响应 NIAAA 研究补充以促进多样性的申请 健康相关研究。候选人的研究将在家长奖项的范围内： 利用光学无创和高分辨率成像技术来评估效果 乙醇和大麻素暴露对胎儿大脑生长的影响并分析 支持大脑发育的脉管系统。补充父级中描述的方法 授予，候选人将使用荧光进行胚胎成像的额外实验 和超声成像技术，以证实正在进行的和已经发表的 光学相干断层扫描 (OCT) 成像结果。 候选人的培训计划包括研究、沟通和写作的发展 酒精和药物滥用的生理学和生物物理学方面的技能和广泛的培训。 。